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Applications of contemporary tools to measure plasma protein binding of targeted protein degraders 当代工具在靶向蛋白降解剂血浆蛋白结合测量中的应用 Niosi, Mark; Zhang, Sam; Burchett, Woodrow; Heck, Carley J. S.; Goetz, Gilles H.; Federico, James J.; Gernhardt, Steven; Jordan, Samantha; Gilbert, Adam M.; Calabrese, Matthew F.; Obach, R. Scott; Steyn, Stefanus J. 分享 收藏
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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19 Allerton, Charlotte M. N.; Arcari, Joel T.; Aschenbrenner, Lisa M.; Avery, Melissa; Bechle, Bruce M.; Behzadi, Mohammad Amin; Boras, Britton; Buzon, Leanne M.; Cardin, Rhonda D.; Catlin, Natasha R.; Carlo, Anthony A.; Coffman, Karen J.; Dantonio, Alyssa; Di, Li; Eng, Heather; Farley, Kathleen A.; Ferre, Rose Ann; Gernhardt, Steven S.; Gibson, Scott A.; Greasley, Samantha E.; Greenfield, Siennah R.; Hurst, Brett L.; Kalgutkar, Amit S.; Kimoto, Emi; Lanyon, Lorraine F.; Lovett, Gabrielle H.; Lian, Yajing; Liu, Wei; Alsina, Luis A. Martinez; Noell, Stephen; Obach, R. Scott; Owen, Dafydd R.; Patel, Nandini C.; Rai, Devendra K.; Reese, Matthew R.; Rothan, Hussin A.; Sakata, Sylvie; Sammons, Matthew F.; Sathish, Jean G.; Sharma, Raman; Steppan, Claire M.; Tuttle, Jamison B.; Verhoest, Patrick R.; Wei, Liuqing; Yang, Qingyi; Yurgelonis, Irina; Zhu, Yuao 分享 收藏
A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications (vol 25, 102, 2023) Rajan, Shiny Amala Priya; Sherfey, Jason; Ohri, Shivam; Nichols, Lauren; Smith, J. Tyler; Parekh, Paarth; Kadar, Eugene P.; Clark, Frances; George, Billy T.; Gregory, Lauren; Tess, David; Gosset, James R.; Liras, Jennifer; Geishecker, Emily; Obach, R. Scott; Cirit, Murat 分享 收藏
The Importance of Tracking Missing Metabolites: How and Why? Wang, Shuai; Ballard, T. Eric; Christopher, Lisa J.; Foti, Robert S.; Gu, Chungang; Khojasteh, S. Cyrus; Liu, Joyce; Ma, Shuguang; Ma, Bin; Obach, R. Scott; Schadt, Simone; Zhang, Zhoupeng; Zhang, Donglu 分享 收藏
Metabolism and Excretion of Nirmatrelvir in Humans Using Quantitative Fluorine Nuclear Magnetic Resonance Spectroscopy: A Novel Approach for Accelerating Drug Development Singh, Ravi Shankar P.; Walker, Gregory S.; Kadar, Eugene P.; Cox, Loretta M.; Eng, Heather; Sharma, Raman; Bergman, Arthur J.; Van Eyck, Lien; Hackman, Frances; Toussi, Sima S.; Kalgutkar, Amit S.; Obach, R. Scott 分享 收藏
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 Boras, Britton; Jones, Rhys M.; Anson, Brandon J.; Arenson, Dan; Aschenbrenner, Lisa; Bakowski, Malina A.; Beutler, Nathan; Binder, Joseph; Chen, Emily; Eng, Heather; Hammond, Holly; Hammond, Jennifer; Haupt, Robert E.; Hoffman, Robert; Kadar, Eugene P.; Kania, Rob; Kimoto, Emi; Kirkpatrick, Melanie G.; Lanyon, Lorraine; Lendy, Emma K.; Lillis, Jonathan R.; Logue, James; Luthra, Suman A.; Ma, Chunlong; Mason, Stephen W.; McGrath, Marisa E.; Noell, Stephen; Obach, R. Scott; O' Brien, Matthew N.; O'Connor, Rebecca; Ogilvie, Kevin; Owen, Dafydd; Pettersson, Martin; Reese, Matthew R.; Rogers, Thomas F.; Rosales, Romel; Rossulek, Michelle I.; Sathish, Jean G.; Shirai, Norimitsu; Steppan, Claire; Ticehurst, Martyn; Updyke, Lawrence W.; Weston, Stuart; Zhu, Yuao; White, Kris M.; Garcia-Sastre, Adolfo; Wang, Jun; Chatterjee, Arnab K.; Mesecar, Andrew D.; Frieman, Matthew B.; Anderson, Annaliesa S.; Allerton, Charlotte 分享 收藏
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes Keefer, Christopher; Chang, George; Carlo, Anthony; Novak, Jonathan J.; Banker, Michael; Carey, Jackie; Cianfrogna, Julie; Eng, Heather; Jagla, Caitlin; Johnson, Nathaniel; Jones, Rhys; Jordan, Samantha; Lazzaro, Sarah; Liu, JianHua; Obach, R. Scott; Riccardi, Keith; Tess, David; Umland, John; Racich, Jillian; Varma, Manthena; Visswanathan, Ravi; Di, Li 分享 收藏
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Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials Tse, Edwin G.; Houston, Sevan D.; Williams, Craig M.; Savage, G. Paul; Rendina, Louis M.; Hallyburton, Irene; Anderson, Mark; Sharma, Raman; Walker, Gregory S.; Obach, R. Scott; Todd, Matthew H. 分享 收藏
Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist Lall, Manjinder S.; Bassyouni, Asser; Bradow, James; Brown, Maria; Bundesmann, Mark; Chen, Jinshan; Ciszewski, Gregory; Hagen, Anne E.; Hyek, Dennis; Jenkinson, Stephen; Liu, Bo; Obach, R. Scott; Pan, Senliang; Reilly, Usa; Sach, Neal; Smaltz, Daniel J.; Spracklin, Douglas K.; Starr, Jeremy; Wagenaar, Melissa; Walker, Gregory S. 分享 收藏
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Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model Ji, Changhua; Guha, Mausumee; Zhu, Xu; Whritenour, Jessica; Hemkens, Michelle; Tse, Susanna; Walker, Gregory S.; Evans, Ellen; Khan, Nasir K.; Finkelstein, Martin B.; Callegari, Ernesto; Obach, R. Scott 分享 收藏
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential Aleo, Michael D.; Shah, Falgun; Allen, Scott; Barton, Hugh A.; Costales, Chester; Lazzaro, Sarah; Leung, Louis; Nilson, Andrea; Obach, R. Scott; Rodrigues, A. David; Will, Yvonne 分享 收藏
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