未登录 Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities 淀粉样蛋白 β 抗体与脑淀粉样血管病原纤维的结合和淀粉样蛋白相关成像异常的风险 Soderberg, Linda; Johannesson, Malin; Gkanatsiou, Eleni; Nygren, Patrik; Fritz, Nicolas; Zachrisson, Olof; Rachalski, Adeline; Svensson, Anne-Sophie; Button, Emily; Dentoni, Giacomo; Osswald, Gunilla; Lannfelt, Lars; Moller, Christer 分享 收藏
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion Pagnon de la Vega, Maria; Syvaenen, Stina; Giedraitis, Vilmantas; Hooley, Monique; Konstantinidis, Evangelos; Meier, Silvio R.; Rokka, Johanna; Eriksson, Jonas; Aguilar, Ximena; Spires-Jones, Tara L.; Lannfelt, Lars; Nilsson, Lars N. G.; Erlandsson, Anna; Hultqvist, Greta; Ingelsson, Martin; Sehlin, Dag 分享 收藏
The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy Johansson, Bjorn; Oasa, Sho; Soria, Aida Muntsant; Tiiman, Ann; Soderberg, Linda; Amandius, Ebba; Moller, Christer; Lannfelt, Lars; Terenius, Lars; Gimenez-Llort, Lydia; Vukojevic, Vladana 分享 收藏
Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease Lecanemab，aducaanumab和Gantenerumab对不同形式的淀粉样蛋白-β 的结合谱可能解释了阿尔茨海默病临床试验中的疗效和副作用 Soderberg, Linda; Johannesson, Malin; Nygren, Patrik; Laudon, Hanna; Eriksson, Fredrik; Osswald, Gunilla; Moller, Christer; Lannfelt, Lars 分享 收藏
Aβ and tau prions feature in the neuropathogenesis of Down syndrome Condello, Carlo; Maxwell, Alison M.; Castillo, Erika; Aoyagi, Atsushi; Graff, Caroline; Ingelsson, Martin; Lannfelt, Lars; Bird, Thomas D.; Keene, C. Dirk; Seeley, William W.; Perl, Daniel P.; Head, Elizabeth; Prusiner, Stanley B. 分享 收藏
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody (vol 13, 80, 2021) Swanson, Chad J.; Zhang, Yong; Dhadda, Shobha; Wang, Jinping; Kaplow, June; Lai, Robert Y. K.; Lannfelt, Lars; Bradley, Heather; Rabe, Martin; Koyama, Akihiko; Reyderman, Larisa; Berry, Donald A.; Berry, Scott; Gordon, Robert; Kramer, Lynn D.; Cummings, Jeffrey L. 分享 收藏
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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease Nordstrom, Eva; Eriksson, Fredrik; Sigvardson, Jessica; Johannesson, Malin; Kasrayan, Alex; Jones-Kostalla, Martina; Appelkvist, Paulina; Soderberg, Linda; Nygren, Patrik; Blom, Magdalena; Rachalski, Adeline; Nordenankar, Karin; Zachrisson, Olof; Amandius, Ebba; Osswald, Gunilla; Moge, Mikael; Ingelsson, Martin; Bergstrom, Joakim; Lannfelt, Lars; Moller, Christer; Giorgetti, Marco; Falting, Johanna 分享 收藏
Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken; Lannfelt, Lars; Lilja, Anna M.; Metzendorf, Nicole G.; Gustavsson, Tobias; Sehlin, Dag; Soderberg, Linda; Hultqvist, Greta 分享 收藏
The Amyloid-β Pathway in Alzheimer's Disease 阿尔茨海默病中的淀粉样蛋白-β 途径 Hampel, Harald; Hardy, John; Blennow, Kaj; Chen, Christopher; Perry, George; Kim, Seung Hyun; Villemagne, Victor L.; Aisen, Paul; Vendruscolo, Michele; Iwatsubo, Takeshi; Masters, Colin L.; Cho, Min; Lannfelt, Lars; Cummings, Jeffrey L.; Vergallo, Andrea 分享 收藏
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena; Guener, Goekhan; Zielinski, Mara; Lowenmark, Malin; Brundin, RoseMarie; Danfors, Torsten; Soderberg, Linda; Alafuzoff, Irina; Nilsson, Lars N. G.; Erlandsson, Anna; Willbold, Dieter; Mueller, Stephan A.; Schroeder, Gunnar F.; Hanrieder, Jorg; Lichtenthaler, Stefan F.; Lannfelt, Lars; Sehlin, Dag; Ingelsson, Martin 分享 收藏
Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease 乙酰肝素酶的过表达阻碍了鼠脑中淀粉样蛋白 β 的血管周围清除: 与阿尔茨海默氏病的相关性 Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Yingxia; Zhang, Ganlin; Barash, Uri; Wang, Xiaomin; Lannfelt, Lars; Vlodavsky, Israel; Lindahl, Ulf; Li, Jin-Ping 分享 收藏
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody Swanson, Chad J.; Zhang, Yong; Dhadda, Shobha; Wang, Jinping; Kaplow, June; Lai, Robert Y. K.; Lannfelt, Lars; Bradley, Heather; Rabe, Martin; Koyama, Akihiko; Reyderman, Larisa; Berry, Donald A.; Berry, Scott; Gordon, Robert; Kramer, Lynn D.; Cummings, Jeffrey L. 分享 收藏
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Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals Danielsson, Marcus; Halvardson, Jonatan; Davies, Hanna; Torabi Moghadam, Behrooz; Mattisson, Jonas; Rychlicka-Buniowska, Edyta; Jaszczynski, Janusz; Heintz, Julia; Lannfelt, Lars; Giedraitis, Vilmantas; Ingelsson, Martin; Dumanski, Jan P.; Forsberg, Lars A. 分享 收藏
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Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain Aoyagi, Atsushi; Condello, Carlo; Stohr, Jan; Yue, Weizhou; Rivera, Brianna M.; Lee, Joanne C.; Woerman, Amanda L.; Halliday, Glenda; van Duinen, Sjoerd; Ingelsson, Martin; Lannfelt, Lars; Graff, Caroline; Bird, Thomas D.; Keene, C. Dirk; Seeley, William W.; DeGrado, William F.; Prusiner, Stanley B. 分享 收藏
Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers Khoonsari, Payam Emami; Shevchenko, Ganna; Herman, Stephanie; Remnestal, Julia; Giedraitis, Vilmantas; Brundin, RoseMarie; Gunnarsson, Malin Degerman; Kilander, Lena; Zetterberge, Henrik; Nilsson, Peter; Lannfelt, Lars; Ingelsson, Martin; Kultima, Kim 分享 收藏
Mosaic loss of chromosome Y in leukocytes matters Forsberg, Lars A.; Halvardson, Jonatan; Rychlicka-Buniowska, Edyta; Danielsson, Marcus; Moghadam, Behrooz Torabi; Mattisson, Jonas; Rasi, Chiara; Davies, Hanna; Lind, Lars; Giedraitis, Vilmantas; Lannfelt, Lars; Kilander, Lena; Ingelsson, Martin; Dumanski, Jan P. 分享 收藏
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