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G

Galina Karabanovich

faculty of pharmacy in hradec kralove
H指数:13
被引数:685

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery and Pharmacological Profiling of Quinoline- and Quinoxaline-Based Phenoxypropanoic Acid Derivatives as Multitarget Modulators of PPARα, FXR, and LXRα receptors

喹啉基和喹喔啉基苯氧基丙酸衍生物的发现及其作为PPARα、FXR和LXRα受体多靶点调节剂的药理学表征

European Journal of Medicinal Chemistry
IF5.9
2026-10-270
OAAI
Iuliia Melnikova; Galina Karabanovich; Jan Dušek; Martin Ambrož; Hana Laštůvková; Tomaš Smutný; Mária Bajnoková; Rajamanikkam Kamaraj; Rudy Salam; Adam Reguli; Petra Štěrbová-Kovaříková; Otto Kučera; Stanislav Mičuda; Jaroslav Roh; Petr Pávek
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection

Topobexin靶向Topoisomerase II ATPase结构域，以实现β异构体选择性抑制和蒽环类心脏保护。

NATURE COMMUNICATIONS
IF15.7
2025-05-280
OA
Kubes, Jan; Karabanovich, Galina; Cong, Anh T. Q.; Melnikova, Iuliia; Lencova, Olga; Kollarova, Petra; Bavlovic Piskackova, Hana; Kerestes, Veronika; Applova, Lenka; Arrouye, Lise C. M.; Alvey, Julia R.; Paluncic, Jasmina; Witter, Taylor L.; Jirkovska, Anna; Kunes, Jiri; Sterbova-Kovarikova, Petra; Austin, Caroline A.; Sterba, Martin; Simunek, Tomas; Roh, Jaroslav; Schellenberg, Matthew J.
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-12-291
OAAI
Karabanovich, Galina; Fabianova, Viktoria; Vocat, Anthony; Dusek, Jan; Valaskova, Lenka; Stolarikova, Jirina; Kitson, Russell R. A.; Pavek, Petr; Vavrova, Katerina; Djaout, Kamel; Mikusova, Katarina; Baulard, Alain R.; Cole, Stewart T.; Kordulakova, Jana; Roh, Jaroslav
Cardioprotective Effects Of Dexrazoxane Derivatives Against Chronic Anthracycline Cardiotoxicity Depend On Topoisomerase II Beta Inhibition And Prevention Of DNA Damage Signaling In The Heart

右雷佐生衍生物对慢性蒽环类药物心脏毒性的心脏保护作用取决于拓扑异构酶II β 的抑制作用和心脏DNA损伤信号的预防

CIRCULATION RESEARCH
IF16.2
2022-08-050
PRE
Kollarova, Petra; Lencova, Olga; Karabanovich, Galina; Kubes, Jan; Vanova, Nela; Roh, Jaroslav; Simunek, Tomas; Sterbova, Petra; Sterba, Martin
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation

右雷佐生对蒽环类药物心脏毒性的临床上可翻译的预防是由拓扑异构酶II β 介导的，而不是金属螯合

jacc heart failure
IF8.4
2021-11-0139
OA
Jirkovsky, Eduard; Jirkovska, Anna; Bavlovic-Piskackova, Hana; Skalicka, Veronika; Pokorna, Zuzana; Karabanovich, Galina; Kollarova-Brazdova, Petra; Kubes, Jan; Lencova-Popelova, Olga; Mazurova, Yvona; Adamcova, Michaela; Lyon, Alexander R.; Roh, Jaroslav; Simunek, Tomas; Sterbova-Kovarikova, Petra; Sterba, Martin
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2216
OAAI
Jirkovska, Anna; Karabanovich, Galina; Kubes, Jan; Skalicka, Veronika; Melnikova, Iuliia; Korabecny, Jan; Kucera, Tomas; Jirkovsky, Eduard; Novakova, Lucie; Piskackova, Hana Bavlovic; Skoda, Josef; Sterba, Martin; Austin, Caroline A.; Simunek, Tomas; Roh, Jaroslav
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2020-06-0114
OAAI
Kollarova-Brazdova, Petra; Jirkovska, Anna; Karabanovich, Galina; Pokorna, Zuzana; Piskackova, Hana Bavlovic; Jirkovsky, Eduard; Kubes, Jan; Lencova-Popelova, Olga; Mazurova, Yvona; Adamcova, Michaela; Skalicka, Veronika; Sterbova-Kovarikova, Petra; Roh, Jaroslav; Simunek, Tomas; Sterba, Martin
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2′-Oxidase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-08-0841
PREAI
Karabanovich, Galina; Dusek, Jan; Savkova, Karin; Pavlis, Oto; Pavkova, Ivona; Korabecny, Jan; Kucera, Tomas; Vlckova, Hana Kocova; Huszar, Stanislav; Konyarikova, Zuzana; Konecna, Klara; Jand'ourek, Ondrej; Stolarikova, Jirina; Kordulakova, Jana; Vavrova, Katerina; Pavek, Petr; Klimesova, Vera; Hrabalek, Alexandr; Mikusova, Katarina; Roh, Jaroslav
EFFECTIVE CARDIOPROTECTION AGAINST ANTHRACYCLINE CARDIOTOXICITY IN ISOLATED CARDIOMYOCYTES AND RABBITS IS BASED ON DEXRAZOXANE INTERACTION WITH TOPOISOMERASE II BETA INSTEAD OF IRON CHELATION BY ITS METABOLITE ADR-925
HEART
IF4.4
2019-05-010
OAAI
Jirkovsky, Eduard; Jirkovska, Anna; Bavlovic-Piskackova, Hana; Skalicka, Veronika; Pokorna, Zuzana; Karabanovich, Galina; Brazdova, Petra; Lencova-Popelova, Olga; Mazurova, Yvona; Adamcova, Michaela; Roh, Jaroslav; Sterbova-Kovarikova, Petra; Simunek, Tomas; Sterba, Martin
S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents

S-取代的3，5-二硝基苯基1,3，4-恶二唑-2-硫醇和tetrazole-5-thiols作为高效抗结核药

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2017-01-0154
PREAI
Karabanovich, Galina; Nemecek, Jan; Valaskova, Lenka; Carazo, Alejandro; Konecna, Klara; Stolarikova, Jirina; Hrabalek, Alexandr; Pavlis, Oto; Pavek, Petr; Vavrova, Katerina; Roh, Jaroslav; Klimesova, Vera
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-1595
PREAI
Karabanovich, Galina; Zemanova, Julia; Smutny, Tomas; Szekely, Rita; Sarkan, Michal; Centarova, Ivana; Vocat, Anthony; Pavkova, Ivona; Conka, Patrik; Nemecek, Jan; Stolarikova, Jirina; Vejsova, Marcela; Vavrova, Katerina; Klimesova, Vera; Hrabalek, Alexandr; Pavek, Petr; Cole, Stewart T.; Mikusova, Katarina; Roh, Jaroslav
1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria

1-取代-5-[(3，5-二硝基苄基) 硫烷基]-1h-四唑及其等排类似物: 一类新的选择性抗结核药，对药物敏感和多重耐药分枝杆菌具有活性

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2014-07-0150
PREAI
Karabanovich, Galina; Roh, Jaroslav; Smutny, Tomas; Nemecek, Jan; Vicherek, Petr; Stolarikova, Jirina; Vejsova, Marcela; Dufkova, Ida; Vavrova, Katerina; Pavek, Petr; Klimesova, Vera; Hrabalek, Alexandr

研究方向

暂未获取到该数据
J
Jaroslav Roh
H 指数:24论文数:88被引数:1,918
T
Tomáš Šimůnek
H 指数:35论文数:113被引数:4,041
A
Anna Jirkovská
H 指数:14论文数:28被引数:392
M
Martin Štěrba
H 指数:32论文数:129被引数:4,460
J
Jan Kubeš
H 指数:9论文数:25被引数:239
H
Hana Bavlovič Piskáčková
H 指数:8论文数:16被引数:214
P
Petra Štěrbová‐Kovaříková
H 指数:9论文数:22被引数:237
K
Kateřina Vávrová
H 指数:40论文数:180被引数:5,012
P
Petra Kollárová-Brázdová
H 指数:6论文数:15被引数:153
J
Jiřina Stolaříková
H 指数:25论文数:66被引数:1,789