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D

Dong Xiao

merck & co., inc.
H指数:17
被引数:721

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荣誉奖项

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Discovery of Potent and Selective Benzothiophene Difluoromethyl Phosphonate (DFMP) PTPN2/N1-Dual Inhibitors

发现强效且选择性苯并噻吩二氟甲基磷酸酯（DFMP）PTPN2/N1-双抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-04-290
PRE
Xiao Mei Zheng; David A. Candito; James Jewell; Matthew Childers; Shuhei Kawamura; Kaitlyn M. Logan; Ryan D. Otte; Charles S. Yeung; Dong Xiao; Ping Liu; Duane E. DeMong; Chunhui Huang; Sulagna Sanyal; Meredeth McGowan; Samuel M. Levi; Sebastian E. Schneider; Xavier Fradera; Rachel L. Palte; Thomas W. Lyons; Kelsey E. Poremba; J. Richard Miller; Xiaomei Chai; Zangwei Xu; Isaac Musisi; My S. Mansueto; Sriraman Venkataraman; Lily Y. Moy; Minjia Zhang; Yi Yang; Mangeng Cheng; Robbie McLeod; Jason Laskey; Minilik Angagaw; Dustin M. Smith; Ninad Varkhede; Eric S. Muise; Alan Bass; Jason Walraven; Amy Doty; Hongshi Yu; Barbara Rath; Laura Engstrom; Hongmei Wang; Nicole E. Follmer; Michael Slavonic; Tobias Ehrenberger; Benjamin Nicholson; W. Nicholas Haining; David Jonathan Bennett; Erin F. DiMauro; Michelle R. Machacek; Stuart Shumway
Discovery of Potent 1; 3-Cyclobutane-Containing Dual A2A/A2B Receptor Antagonists with Low Projected Human Dose for the Treatment of Cancer

具有低剂量潜力的含1,3-环丁烷基的双A2A/A2B受体拮抗剂的发现及其在癌症治疗中的应用

ACS Medicinal Chemistry Letters
IF4
2026-04-140
PRE
Zachary G. Brill; Alec H. Christian; Lorena Rico; Sebastian E. Schneider; Eric M. Phillips; Matthew S. Winston; Harini Krishnamurthy; Elisabeth T. Hennessy; Umar Faruk Mansoor; Dong Xiao; Jing Su; Ping Liu; Christopher Plummer; Anthony Palmieri; Julia Vela Ramirez; Armetta Hill; William Dewey; Daniel Tatosian; Diane Rindgen; Oluwaseun Ogunbodede; Nadya Smotrov; Jennifer Piesvaux; Paul Ciaccio; Peter Fan; Roshi Afshar; Pierre Daublain; Jeremy Presland; Karin M. Otte; Amjad Ali; Jared Cumming; Sheila Ranganath; Duane DeMong
Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease (vol. 69, pg. 8548, 2026)

发现强效、选择性、中枢神经系统穿透性大环LRRK2抑制剂用于帕金森病的治疗（vol. 69, pg. 8548, 2026）

Journal of Medicinal Chemistry
IF6.8
2026-04-010
PRE
Yu, Elsie C.; Zhou, Hua; Yan, Xin; Logan, Kaitlyn M.; Li, Derun; Gulati, Anmol; Poremba, Kelsey E.; Ardolino, Michael J.; Su, Jing; Xiao, Dong; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa M.; Adpressa, Donovon A.; Burgess, Samantha A.; Xiong, Tina; Otte, Karin M.; Chobanian, Harry R.; Bass, Alan; Lee, Susi; Pearson, Kara; Messina, Eric; Parisi, Michael; Barnum, John; Sobol, Zhanna; Ciaccio, Paul J.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Discovery of Potent; Selective; CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

发现强效、选择性、能穿透中枢神经系统的环状LRRK2抑制剂，用于帕金森病的治疗

Journal of Medicinal Chemistry
IF6.8
2026-03-290
PRE
Elsie C. Yu; Hua Zhou; Xin Yan; Kaitlyn M. Logan; Derun Li; Anmol Gulati; Kelsey E. Poremba; Michael J. Ardolino; Jing Su; Dong Xiao; Rachel L. Palte; Spencer E. McMinn; Lisa M. Nogle; Donovon A. Adpressa; Samantha A. Burgess; Tina Xiong; Karin M. Otte; Harry R. Chobanian; Alan Bass; Susi Lee; Kara Pearson; Eric Messina; Michael Parisi; John Barnum; Zhanna Sobol; Paul J. Ciaccio; Erin F. DiMauro; Matthew J. Fell; Peter H. Fuller
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-10-205
PRE
Kattar, Solomon D.; Gulati, Anmol; Margrey, Kaila A.; Keylor, Mitchell H.; Ardolino, Michael; Yan, Xin; Johnson, Rebecca; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Su, Jing; Xiao, Dong; Piesvaux, Jennifer; Lee, Susi; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Moy, Lily Y.; Xiong, Tina; Ciaccio, Paul J.; Pearson, Kara; Patel, Mayankbhai; Otte, Karin M.; Leyns, Cheryl E. G.; Kennedy, Matthew E.; Bennett, David Jonathan; Dimauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2018-06-149
OAAI
Chen, Helen Y.; Plummer, Christopher W.; Xiao, Dong; Chobanian, Harry R.; DeMong, Duane; Miller, Michael; Trujillo, Maria E.; Kirkland, Melissa; Kosinski, Daniel; Mane, Joel; Pachanski, Michele; Cheewatrakoolpong, Boonlert; Di Salvo, Jerry; Thomas-Fowlkes, Brande; Souza, Sarah; Tatosian, Daniel A.; Chen, Qing; Hafey, Michael J.; Houle, Robert; Nolting, Andrew F.; Orr, Robert; Ehrhart, Juliann; Weinglass, Adam B.; Tschirret-Guth, Richard; Howard, Andrew D.; Colletti, Steven L.
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2011-11-2932
OAAI
Palani, Anandan; Rao, Ashwin U.; Chen, Xiao; Huang, Xianhai; Su, Jing; Tang, Haiqun; Huang, Ying; Qin, Jun; Xiao, Dong; Degrado, Sylvia; Sofolarides, Michael; Zhu, Xiaohong; Liu, Zhidan; McKittrick, Brian; Zhou, Wei; Aslanian, Robert; Greenlee, William J.; Senior, Mary; Cheewatrakoolpong, Boonlert; Zhang, Hongtao; Farley, Constance; Cook, John; Kurowski, Stan; Li, Qiu; van Heek, Margaret; Wang, Gangfeng; Hsieh, Yunsheng; Lo, Fangbiao; Greenfeder, Scott; Chintala, Madhu
Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2010-12-0819
OA
Qin, Jun; Rao, Ashwin; Chen, Xiao; Zhu, Xiaohong; Liu, Zhidan; Huang, Xianhai; Degrado, Sylvia; Huang, Ying; Xiao, Dong; Aslanian, Robert; Cheewatrakoolpong, Boonlert; Zhang, Hongtao; Greenfeder, Scott; Farley, Constance; Cook, John; Kurowski, Stan; Li, Qiu; van Heek, Margaret; Chintala, Madhu; Wang, Ganfeng; Hsieh, Yunsheng; Li, Fangbiao; Palani, Anandan

研究方向

暂未获取到该数据
E
Erin F. DiMauro
H 指数:28论文数:113被引数:2,143
R
R.L. Palte
H 指数:10论文数:43被引数:305
P
Paul J. Ciaccio
H 指数:23论文数:55被引数:1,867
M
Madeleine M. Joullié
H 指数:44论文数:511被引数:7,479
S
Spencer E. McMinn
H 指数:9论文数:19被引数:302
A
Anmol Gulati
H 指数:8论文数:14被引数:443
M
Michael J. Ardolino
H 指数:12论文数:24被引数:569
D
Duane E. DeMong
H 指数:13论文数:31被引数:1,057
T
Tina Xiong
H 指数:9论文数:12被引数:232
X
Xianhai Huang
H 指数:29论文数:127被引数:2,656