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Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras Tong, Yuquan; Su, Xiaoxuan; Rouse, Warren; Childs-Disney, Jessica L.; Taghavi, Amirhossein; Zanon, Patrick R. A.; Kovachka, Sandra; Wang, Tenghui; Moss, Walter N.; Disney, Matthew D. 分享 收藏
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Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease- targeting chimera 通过靶向核糖核酸酶的嵌合体靶向其结构化mRNA来降低内在无序的蛋白质 α-突触核蛋白水平 Tong, Yuquan; Zhang, Peiyuan; Yang, Xueyi; Liu, Xiaohui; Zhang, Jie; Grudniewska, Magda; Jung, Ikrak; Abegg, Daniel; Liu, Jun; Childs-Disney, Jessica L.; Gibaut, Quentin M. R.; Haniff, Hafeez S.; Adibekian, Alexander; Mouradian, M. Maral; Disney, Matthew D. 分享 收藏
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Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy Gibaut, Quentin M. R.; Bush, Jessica A.; Tong, Yuquan; Baisden, Jared T.; Taghavi, Amirhossein; Olafson, Hailey; Yao, Xiyuan; Childs-Disney, Jessica L.; Wang, Eric T.; Disney, Matthew D. 分享 收藏
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Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA (vol 144, pg. 11260, 2022) Tong, Yuquan; Gibaut, Quentin M. R.; Rouse, Warren; Childs-Disney, Jessica L.; Suresh, Blessy M.; Abegg, Daniel; Choudhary, Shruti; Akahori, Yoshihiro; Adibekian, Alexander; Moss, Walter N.; Disney, Matthew D. 分享 收藏
A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome Bush, Jessica A.; Meyer, Samantha M.; Fuerst, Rita; Tong, Yuquan; Li, Yue; Benhamou, Raphael, I; Aikawa, Haruo; Zanon, Patrick R. A.; Gibaut, Quentin M. R.; Angelbello, Alicia J.; Gendron, Tania F.; Zhang, Yong-Jie; Petrucelli, Leonard; Jensen, Torben Heick; Childs-Disney, Jessica L.; Disney, Matthew D. 分享 收藏
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Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA Tong, Yuquan; Gibaut, Quentin M. R.; Rouse, Warren; Childs-Disney, Jessica L.; Suresh, Blessy M.; Abegg, Daniel; Choudhary, Shruti; Akahori, Yoshihiro; Adibekian, Alexander; Moss, Walter N.; Disney, Matthew D. 分享 收藏
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DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor Benhamou, Raphael I.; Suresh, Blessy M.; Tong, Yuquan; Cochran, Wesley G.; Cavett, Valerie; Vezina-Dawod, Simon; Abegg, Daniel; Childs-Disney, Jessica L.; Adibekian, Alexander; Paegel, Brian M.; Disney, Matthew D. 分享 收藏
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models 在体外和体内ALS模型中使用小分子减少的c9ALS/FTD r(G4C2) 重复扩增的核糖核酸酶募集 Bush, Jessica A.; Aikawa, Haruo; Fuerst, Rita; Li, Yue; Ursu, Andrei; Meyer, Samantha M.; Benhamou, Raphael, I; Chen, Jonathan L.; Khan, Tanya; Wagner-Griffin, Sarah; Van Meter, Montina J.; Tong, Yuquan; Olafson, Hailey; McKee, Kendra K.; Childs-Disney, Jessica L.; Gendron, Tania F.; Zhang, Yongjie; Coyne, Alyssa N.; Wang, Eric T.; Yildirim, Ilyas; Wang, Kye Won; Petrucelli, Leonard; Rothstein, Jeffrey D.; Disney, Matthew D. 分享 收藏
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment 通过核糖核酸酶募集将蛋白质靶向的小分子药物重编程为RNA Zhang, Peiyuan; Liu, Xiaohui; Abegg, Daniel; Tanaka, Toru; Tong, Yuquan; Benhamou, Raphael I.; Baisden, Jared; Crynen, Gogce; Meyer, Samantha M.; Cameron, Michael D.; Chatterjee, Arnab K.; Adibekian, Alexander; Childs-Disney, Jessica L.; Disney, Matthew D. 分享 收藏
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