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S

Samiha A. El-Sebaey

al-azhar university

H指数:12

被引数:357

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Design, synthesis, and biological evaluation of novel thiazolo[3,2-a]pyrimidine derivatives as potential anticancer agents targeting topoisomerase II

新型噻唑并[3,2-<em>a</em>]嘧啶衍生物的设计、合成及其作为靶向拓扑异构酶II的潜在抗癌剂的生物评价

Journal of Molecular Structure

IF4.7

2026-10-100

PRE

Design and synthesis of some novel imidazole-thio-N-substituted-acetamide derivatives as anticancer agents, apoptotic inducers, radio-sensitizers, and EGFR inhibitors

新型咪唑硫基-N-取代乙酰胺衍生物的设计与合成，作为抗癌剂、促凋亡诱导剂、放射增敏剂和EGFR抑制剂

Journal of Molecular Structure

IF4.7

2026-09-290

PRE

Quinoxaline-based scaffolds as dual VEGFR-2/EGFR kinase inhibitors and apoptotic inducers: Design, synthesis, anticancer evaluation, and in silico study

喹喔啉类骨架作为VEGFR-2/EGFR激酶双抑制剂和凋亡诱导剂：设计、合成、抗癌评价及计算机模拟研究

Bioorganic Chemistry

IF4.7

2026-04-250

PRE

Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-Vivo and in-Vitro assays, ADMET and molecular docking simulation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2025-02-011

PRE

In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties

FUTURE MEDICINAL CHEMISTRY

IF3.4

2024-11-122

PRE

Novel thioxoimidazolidinone derivatives as dual EGFR and CDK2 inhibitors: Design, synthesis, anticancer evaluation with in silico study

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2023-11-012

PRE

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

PHARMACEUTICALS

IF4.8

2023-09-153

OAAI

Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2023-07-045

OAAI

Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2023-04-1010

OAAI

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies

SCIENTIFIC REPORTS

IF3.9

2023-04-056

OAAI

Design and synthesis of new series of chiral pyrimidine and purine analogs as COX-2 inhibitors: Anticancer screening, molecular modeling, and in silico studies

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2023-04-019

PRE

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2023-02-128

OAAI

Design, synthesis and molecular modeling study of certain quinazolinone derivatives targeting poly (ADP-ribose) polymerase 1 (PARP-1) enzyme as anti-breast cancer and radio-sensitizers

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2023-02-019

PRE

New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies

IF4.6

2022-11-0212

OAAI

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2021-08-024

OAAI

Potential antiviral and anticancer effect of imidazoles and bridgehead imidazoles generated by HPV-Induced cervical carcinomas via reactivating the P53/ pRb pathway and inhibition of CA IX

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2021-04-0114

PREAI