David D. Schlaepfer - Publications, H-index & Citations

David D. Schlaepfer

Moores Cancer Center

78H指数

239论文数

2.8W被引数

收录论文 111

发表时间

Tumor FAK supports fibrillar collagen expression in ovarian cancer ascites 肿瘤FAK支持卵巢癌腹水中纤维状胶原的表达

Matrix Biology

IF4.8

2026-09-17

PREAI

Marjaana Ojalill; Terrance J. Haanen; Safir Ullah Khan; Yichi Zhang; Antonia Boyer; Xiao Lei Chen; Ujjwal Suwal; Pekka Rappu; Jyrki Heino; Michael T. McHale; Dwayne G. Stupack; David D. Schlaepfer

Disarming cancer resistance: FAK as a therapeutic target 解除癌症耐药性：FAK作为治疗靶点

Trends in Cancer

IF17.5

2026-03-07

OAAI

Terrance J. Haanen; David D. Schlaepfer

Liposomal Doxorubicin, but Not Platinum-Taxane, Supports MHC-II Expression and Immune Maturation in the Ovarian Tumor Microenvironment 脂质体多柔比星，但非铂类-紫杉烷，支持卵巢肿瘤微环境中的MHC-II表达和免疫成熟。

Cancers 2025, Vol. 17, Page 2827

IF4.4

2025-09-04

OAAI

Hyojae Lee; Xiao-Lei Chen; Duygu Ozmadenci; Elise Tahon; Terrance J. Haanan III; Breana Hill; Safir Ullah Khan; Antonia Boyer; David D. Schlaepfer; Dwayne Stupack

Focal adhesion kinase signaling - tumor vulnerabilities and clinical opportunities

JOURNAL OF CELL SCIENCE

IF3.6

2024-07-22

OAAI

Schlaepfer, David D.; Ojalill, Marjaana; Stupack, Dwayne G.

FAK, vinculin, and talin control mechanosensitive YAP nuclear localization FAK，vinculin和talin控制机械敏感的YAP核定位

BIOMATERIALS

IF12.9

2024-07-01

PREAI

Holland, Elijah N.; Fernandez-Yague, Marc A.; Zhou, Dennis W.; 'Neill, Eric B. O.; Woodfolk, Ayanna U.; Mora-Boza, Ana; Fu, Jianping; Schlaepfer, David D.; Garcia, Andres J.

Maintenance therapy inhibition of ptk2 yields decreased disease in preclinical HRP/HRD models of recurrent HGSOC

CANCER RESEARCH

IF16.6

2024-03-04

PREAI

Hill, Breana; Bondre, Ioana; Soylu, H. Meryem; Antoine, Juliette; Chen, Xiao Lei; Tahon, Elise; Zhang, Yichi; Olajill, Marjaana; Kinkel, Sarah; Cock, Terrie-Anne; Binder, Pratibha; Burns, Chris; Schlaepfer, David; McHale, Michael McHale T.; Stupack, Dwayne G.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression (vol 22, pg 497, 2016)

NATURE MEDICINE

IF50

2023-11-28

OAAI

Laklai, Hanane; Miroshnikova, Yekaterina A.; Pickup, Michael W.; Collisson, Eric A.; Kim, Grace E.; Barrett, Alex S.; Hill, Ryan C.; Lakins, Johnathon N.; Schlaepfer, David D.; Mouw, Janna K.; Lebleu, Valerie S.; Roy, Nilotpal; Novitskiy, Sergey V.; Johansen, Julia S.; Poli, Valeria; Kalluri, Raghu; Iacobuzio-Donahue, Christine A.; Wood, Laura D.; Hebrok, Matthias; Hansen, Kirk; Moses, Harold L.; Weaver, Valerie M.

Ovarian tumor-intrinsic FAK-dependent regulation of the matrisome

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Ojalill, Marjaana; Zhang, Joanna; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; Connolly, Denise C.; Stupack, Dwayne G.; Schlaepfer, David D.

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130(cas), and Nck adaptor proteins

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

450

OAAI

Schlaepfer, DD; Broome, MA; Hunter, T

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2 mitogen-activated protein kinase: Summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

405

OAAI

Schlaepfer, DD; Jones, KC; Hunter, T

Integrin α4β1 promotes focal adhesion kinase-independent cell motility via α4 cytoplasmic domain-specific activation of c-Src

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Hsia, DA; Lim, ST; Bernard-Trifilo, JA; Mitra, SK; Tanaka, S; den Hertog, J; Streblow, DN; Ilic, D; Ginsberg, MH; Schlaepfer, DD

Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Cheng, Suzanne Y. S.; Sun, Guobin; Schlaepfer, David D.; Pallen, Catherine J.

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

EXPERIMENTAL AND MOLECULAR MEDICINE

IF12.9

2023-03-01

OAAI

Lee, Seul Gi; Chae, Jongbeom; Woo, Seon Min; Seo, Seung Un; Kim, Ha-Jeong; Kim, Sang-Yeob; Schlaepfer, David D.; Kim, In-San; Park, Hee-Sae; Kwon, Taeg Kyu; Nam, Ju-Ock

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis 肿瘤FAK通过CD155/TIGIT轴协调卵巢癌的免疫抑制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-04-25

OAAI

Ozmadenci, Duygu; Narayanan, Jayanth S. Shankara; Andrew, Jacob; Ojalill, Marjaana; Barrie, Allison M.; Jiang, Shulin; Iyer, Samhita; Chen, Xiao Lei; Rose, Michael; Estrada, Valeria; Molinolo, Alfredo; Bertotto, Thomas; Mikulski, Zbigniew; McHale, Michael C.; White, Rebekah R.; Connolly, Denise C.; Pachter, Jonathan A.; Kuchroo, Vijay K.; Stupack, Dwayne G.; Schlaepfer, David D.

FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

CIRCULATION RESEARCH

IF16.2

2021-12-03

OAAI

Jeong, Kyuho; Murphy, James M.; Kim, Jung-Hyun; Campbell, Pamela Moore; Park, Hyeonsoo; Rodriguez, Yelitza; Choi, Chungsik; Kim, Jun-Sub; Park, Sangwon; Kim, Hyun Joon; Scammell, Jonathan G.; Weber, David S.; Honkanen, Richard E.; Schlaepfer, David D.; Ahn, Eun-Young Erin; Lim, Ssang-Taek Steve

Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI

SCIENTIFIC REPORTS

IF3.9

2021-05-06

OAAI

Lee, Seul Gi; Kim, Jin Soo; Kim, Ha-Jeong; Schlaepfer, David D.; Kim, In-San; Nam, Ju-Ock

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair 单个粘着斑处的Force-FAK信号耦合协调机械传感和微组织修复

NATURE COMMUNICATIONS

IF15.7

2021-04-21

OAAI

Zhou, Dennis W.; Fernandez-Yaguee, Marc A.; Holland, Elijah N.; Garcia, Andres F.; Castro, Nicolas S.; O'Neill, Eric B.; Eyckmans, Jeroen; Chen, Christopher S.; Fu, Jianping; Schlaepfer, David D.; Garcia, Andres J.

Targeting FAK in anticancer combination therapies

NATURE REVIEWS CANCER

IF66.8

2021-03-17

212

OAAI

Dawson, John C.; Serrels, Alan; Stupack, Dwayne G.; Schlaepfer, David D.; Frame, Margaret C.

FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

EMBO MOLECULAR MEDICINE

IF8.3

2020-10-07

OAAI

Zaghdoudi, Sonia; Decaup, Emilie; Belhabib, Ismahane; Samain, Remi; Cassant-Sourdy, Stephanie; Rochotte, Julia; Brunel, Alexia; Schlaepfer, David; Cros, Jerome; Neuzillet, Cindy; Strehaiano, Manon; Alard, Amandine; Tomasini, Richard; Rajeeve, Vinothini; Perraud, Aurelie; Mathonnet, Muriel; Pearce, Oliver M. T.; Martineau, Yvan; Pyronnet, Stephane; Bousquet, Corinne; Jean, Christine

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

PLOS GENETICS

IF3.7

2020-01-10

OAAI

Delaney, Joe R.; Patel, Chandni B.; Bapat, Jaidev; Jones, Christian M.; Ramos-Zapatero, Maria; Ortell, Katherine K.; Tanios, Ralph; Haghighiabyaneh, Mina; Axelrod, Joshua; DeStefano, John W.; Tancioni, Isabelle; Schlaepfer, David D.; Harismendy, Olivier; La Spada, Albert R.; Stupack, Dwayne G.

研究方向