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K

Klas G. Wiman

karolinska institutet

H指数:74

被引数:1.8万

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A breakthrough in p53-targeted therapy

p53靶向治疗取得突破

IF28.5

2026-10-010

PRE

Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

携带无义突变p53的小鼠会发展出频繁的多中心性或转移性肿瘤

Cell Death & Disease

IF9.6

2025-12-110

OAAI

Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

IF6.9

2024-10-010

OAAI

Pharmacological reactivation of p53 in the era of precision anticancer medicine

NATURE REVIEWS CLINICAL ONCOLOGY

IF82.2

2023-12-1523

PRE

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

与氨基糖苷G418或eRF3降解剂协同作用的新型化合物，用于无义突变体TP53和PTEN的翻译通读

IF3.4

2023-06-203

OAAI

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

IF7.3

2023-01-272

OAAI

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

CELL DEATH & DISEASE

IF9.6

2022-11-2514

OAAI

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)

CELL DEATH & DISEASE

IF9.6

2022-08-030

OAAI

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

CELL DEATH & DISEASE

IF9.6

2022-03-0711

OAAI

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

CELL DEATH & DISEASE

IF9.6

2021-07-1515

OAAI

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

EMBO MOLECULAR MEDICINE

IF8.3

2020-12-1431

OAAI

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

CELL DEATH AND DIFFERENTIATION

IF15.4

2020-11-3026

OAAI

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

CELL DEATH DISCOVERY

IF7

2020-06-0269

OAAI

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 (vol 9, 439, 2018)

CELL DEATH & DISEASE

IF9.6

2019-10-105

OAAI

Role of Thiol Reactivity for Targeting Mutant p53

CELL CHEMICAL BIOLOGY

IF7.2

2018-10-0116

OAAI

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

突变p53-targeting化合物APR-246对谷氧还蛋白和硫氧还蛋白系统和核糖核苷酸还原酶的抑制作用

SCIENTIFIC REPORTS

IF3.9

2018-08-2359

OAAI

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

CELL DEATH & DISEASE

IF9.6

2018-04-18213

OAAI

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

FRONTIERS IN ONCOLOGY

IF3.3

2018-01-0430

OAAI

Targeting mutant p53 for efficient cancer therapy

NATURE REVIEWS CANCER

IF66.8

2017-12-15715

PREAI

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (vol 280, pg 30384, 2005)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-12-0112

OAAI