Klas G. Wiman - Publications, H-index & Citations

Klas G. Wiman

Department of Oncology-Pathology

74H指数

236论文数

1.8W被引数

收录论文 99

发表时间

Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors 携带无义突变p53的小鼠会发展出频繁的多中心性或转移性肿瘤

Cell Death & Disease

IF9.6

2025-12-11

OAAI

Charlotte Strandgren; Veronica Rondahl; Ann-Sophie Oppelt; Susanne Öhlin; Angelos Heldin; Klas G. Wiman

Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

CELL REPORTS

IF6.9

2024-10-01

OAAI

Ramos, Anderson Daniel; Liang, Ying Yu; Surova, Olga; Bacanu, Smaranda; Gerault, Marc-Antoine; Mandal, Tamoghna; Ceder, Sophia; Langeback, Anette; Osterroos, Albin; Ward, George A.; Bergh, Jonas; Wiman, Klas G.; Lehmann, Soren; Prabhu, Nayana; Loof, Sara; Nordlund, Par

Pharmacological reactivation of p53 in the era of precision anticancer medicine

NATURE REVIEWS CLINICAL ONCOLOGY

IF82.2

2023-12-15

PREAI

Tuval, Amos; Strandgren, Charlotte; Heldin, Angelos; Palomar-Siles, Mireia; Wiman, Klas G.

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN 与氨基糖苷G418或eRF3降解剂协同作用的新型化合物，用于无义突变体TP53和PTEN的翻译通读

RNA BIOLOGY

IF3.4

2023-06-20

OAAI

Heldin, Angelos; Cancer, Matko; Palomar-Siles, Mireia; Ohlin, Susanne; Zhang, Meiqiongzi; Sun-Zhang, Alexander; Mariani, Anna; Liu, Jianping; Bykov, Vladimir J. N.; Wiman, Klas G. G.

Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

ONCOGENE

IF7.3

2023-01-27

OAAI

Bersani, C.; Xu, L. -d.; Vilborg, A.; Lui, W. -o.; Wiman, K. G.

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

CELL DEATH & DISEASE

IF9.6

2022-11-25

OAAI

Palomar-Siles, Mireia; Heldin, Angelos; Zhang, Meiqiongzi; Strandgren, Charlotte; Yurevych, Viktor; van Dinter, Jip T.; Engels, Sem A. G.; Hofman, Damon A.; Ohlin, Susanne; Meineke, Birthe; Bykov, Vladimir J. N.; van Heesch, Sebastiaan; Wiman, Klas G.

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)

CELL DEATH & DISEASE

IF9.6

2022-08-03

OAAI

Ceder, Sophia; Eriksson, Sofi E.; Liang, Ying Yu; Cheteh, Emarndeena H.; Zhang, Si Min; Fujihara, Kenji M.; Bianchi, Julie; Bykov, Vladimir J. N.; Abrahmsen, Lars; Clemons, Nicholas J.; Nordlund, Par; Rudd, Sean G.; Wiman, Klas G.

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

CELL DEATH & DISEASE

IF9.6

2022-03-07

OAAI

Zhang, Qiang; Balourdas, Dimitrios-Ilias; Baron, Bruno; Senitzki, Alon; Haran, Tali E.; Wiman, Klas G.; Soussi, Thierry; Joerger, Andreas C.

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

CELL DEATH & DISEASE

IF9.6

2021-07-15

OAAI

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

EMBO MOLECULAR MEDICINE

IF8.3

2020-12-14

OAAI

Ceder, Sophia; Eriksson, Sofi E.; Cheteh, Emarndeena H.; Dawar, Swati; Corrales Benitez, Mariana; Bykov, Vladimir J. N.; Fujihara, Kenji M.; Grandin, Melodie; Li, Xiaodun; Ramm, Susanne; Behrenbruch, Corina; Simpson, Kaylene J.; Hollande, Frederic; Abrahmsen, Lars; Clemons, Nicholas J.; Wiman, Klas G.

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

CELL DEATH AND DIFFERENTIATION

IF15.4

2020-11-30

OAAI

Doffe, Flora; Carbonnier, Vincent; Tissier, Manon; Leroy, Bernard; Martins, Isabelle; Mattsson, Johanna S. M.; Micke, Patrick; Pavlova, Sarka; Pospisilova, Sarka; Smardova, Jana; Joerger, Andreas C.; Wiman, Klas G.; Kroemer, Guido; Soussi, Thierry

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

CELL DEATH DISCOVERY

IF7

2020-06-02

OAAI

Cheteh, Emarndeena H.; Sarne, Victoria; Ceder, Sophia; Bianchi, Julie; Augsten, Martin; Rundqvist, Helene; Egevad, Lars; Ostman, Arne; Wiman, Klas G.

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 (vol 9, 439, 2018)

CELL DEATH & DISEASE

IF9.6

2019-10-10

OAAI

Zhang, Qiang; Bykov, Vladimir J. N.; Wiman, Klas G.; Zawacka-Pankau, Joanna

Role of Thiol Reactivity for Targeting Mutant p53

CELL CHEMICAL BIOLOGY

IF7.2

2018-10-01

OAAI

Zhang, Qiang; Bergman, Jan; Wiman, Klas G.; Bykov, Vladimir J. N.

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246 突变p53-targeting化合物APR-246对谷氧还蛋白和硫氧还蛋白系统和核糖核苷酸还原酶的抑制作用

SCIENTIFIC REPORTS

IF3.9

2018-08-23

OAAI

Haffo, Lena; Lu, Jun; Bykov, Vladimir J. N.; Martin, Sebastin S.; Ren, Xiaoyuan; Coppo, Lucia; Wiman, Klas G.; Holmgren, Arne

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

CELL DEATH & DISEASE

IF9.6

2018-04-18

213

OAAI

Zhang, Qiang; Bykov, Vladimir J. N.; Wiman, Klas G.; Zawacka-Pankau, Joanna

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

FRONTIERS IN ONCOLOGY

IF3.3

2018-01-04

OAAI

Zhang, Meiqiongzi; Heldin, Angelos; Palomar-Siles, Mireia; Ohlin, Susanne; Bykov, Vladimir J. N.; Wiman, Klas G.

Targeting mutant p53 for efficient cancer therapy

NATURE REVIEWS CANCER

IF66.8

2017-12-15

715

PREAI

Bykov, Vladimir J. N.; Eriksson, Sofi E.; Bianchi, Julie; Wiman, Klas G.

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (vol 280, pg 30384, 2005)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-12-01

OAAI

Bykov, Vladimir J. N.; Issaeva, Natalia; Zache, Nicole; Shilov, Alexandre; Hultcrantz, Monica; Bergman, Jan; Selivanova, Galina; Wiman, Klas G.

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

CELL DEATH & DISEASE

IF9.6

2017-06-01

OAAI

Cheteh, Emarndeena H.; Augsten, Martin; Rundqvist, Helene; Bianchi, Julie; Sarne, Victoria; Egevad, Lars; Bykov, Vladimir J. N.; Ostman, Arne; Wiman, Klas G.

研究方向