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S

Shirit Einav

Stanford University
H指数:34
被引数:3,818

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A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease

单个人类中性粒细胞细胞图谱揭示健康与疾病中中性粒细胞的异质性

Nature Immunology
IF27.6
2026-10-210
OAAI
Hong Zheng; Evan Maestri; Andrew R. Moore; Ananthakrishnan Ganesan; Jeanna Enriquez; Verónica Durán; Shirit Einav; Tom van der Poll; Hjalmar R. Bouma; Mihir R. Atreya; Philip A. Efron; Lyle L. Moldawer; Jonathan Sevransky; David W. Wright; Ignacio Martin-Loeches; Thomas Karvunidis; Jeremiah Hinson; David N. Hager; Richard E. Rothman; Evangelos J. Giamarellos-Bourboulis; Timothy E. Sweeney; Angela J. Rogers; Saurabh Gombar; Manoj V. Maddali; Jonathan H. Chen; Nigam Shah; Purvesh Khatri
Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve

3,5-二取代异噻唑并[4,5-b]吡啶、吡唑并[4,3-b]吡啶和异噻唑并[3,4-b]吡嗪的合成与评价及其作为PIKfyve抑制剂的评估

Bioorganic Chemistry
IF4.7
2026-08-010
PRE
Gao, Ling-Jie; Froeyen, Mathy; Lo, Chieh-Wen; Tran, Do Hoang Nhu; Van Loy, Tom; Schols, Dominique; Rozenski, Jef; Dehaen, Wim; Einav, Shirit; De Jonghe, Steven
Comprehensive metabolomics combined with machine learning for the identification of SARS-CoV-2 and other viruses directly from upper respiratory samples

综合代谢组学结合机器学习方法，用于直接从上呼吸道样本中鉴定SARS-CoV-2及其他病毒

JOURNAL OF CLINICAL MICROBIOLOGY
IF5.4
2025-10-010
PRE
Hogan, Catherine A.; Le, Anthony T.; Khan, Afraz; Su, LingHui David; Huang, Chunhong; Sahoo, Malaya K.; Lo, Chieh-Wen; Karim, Marwah; Stein, Karin Ann; Einav, Shirit; Cowan, Tina M.; Pinsky, Benjamin A.
Structure–Activity Relationship Study of 3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines as Dual Inhibitors of the Lipid Kinases PIKfyve and PIP4K2C

3-炔基-6-芳基-异噻唑并[4,3-b]吡啶类化合物的结构-活性关系研究：作为PIKfyve和PIP4K2C脂质激酶的双重抑制剂

Pharmaceuticals 2025, Vol. 18, Page 1341
IF4.8
2025-09-210
OAAI
Demian Kalebic; Ling-Jie Gao; Belén Martinez-Gualda; Marwah Karim; Sirle Saul; Do Hoang Nhu Tran; Jef Rozenski; Leentje Persoons; Dominique Schols; Wim Dehaen; Shirit Einav; Steven De Jonghe
Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1.

基于吡唑并[1,5-a]嘧啶的靶向AAK1的大环激酶抑制剂的开发。

European Journal of Medicinal Chemistry
IF5.9
2025-08-220
PREAI
Theresa E. Mensing; Christian G. Kurz; Jennifer A. Amrhein; Theresa A.L. Ehret; Franziska Preuss; Sebastian Mathea; Marwah Karim; Do Hoang Nhu Tran; Zuzana Kadlecova; Tuomas A. Tolvanen; Daniel Martinez-Molina; Susanne Müller; Shirit Einav; Stefan Knapp; Thomas Hanke
Discovery of antivirally active inhibitors of adaptor protein-2 associated kinase 1 based on various bicyclic heteroaromatic scaffolds derived from a 7-azaindole analogue

基于7-氮杂吲哚类似物衍生的多种双环杂芳香骨架的病毒适应性蛋白-2相关激酶1的抗病毒活性抑制剂发现

European Journal of Medicinal Chemistry
IF5.9
2025-07-240
PRE
Stijn Anthonissen; Wout Van Eynde; Marwah Karim; Ling-Jie Gao; Do Hoang Nhu Tran; Dominique Schols; Arnout Voet; Shirit Einav; Wim Dehaen; Steven De Jonghe
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

Karim, M.; Mishra, M.; Lo, C.W.; Saul, S.; Cagirici, H.; Gourdelier, M.; Ghita, L.; Ojha, A.; Tran, D.H.N.; Agrawal, A.; et al. PIP4K2C抑制逆转由SARS-CoV-2引起的自噬流障碍。Nat. Commun. 2025, 16, 6397. [Google Scholar] [CrossRef]

Nature Communications
IF15.7
2025-07-100
OAAI
Marwah Karim; Manjari Mishra; Chieh-Wen Lo; Sirle Saul; Halise Busra Cagirici; Manon Gourdelier; Luca Ghita; Amrita Ojha; Do Hoang Nhu Tran; Aditi Agrawal; Connor McGraw; Michael P. East; Karen Anbro Gammeltoft; Malaya Kumar Sahoo; Nancie A. Mooney; Gary L. Johnson; Soumita Das; Pieter Leyssen; Johan Neyts; Winston Chiu; Courtney A. Cohen; Jens Bukh; Judith Gottwein; John M. Dye; Norma Neff; Peter K. Jackson; Benjamin A. Pinsky; Tuomo Laitinen; Tatu Pantsar; Antti Poso; Fabio Zanini; Steven De Jonghe; Christopher R. M. Asquith; Shirit Einav
Synthesis of 3-heteroaryl-pyrrolo[2,3-b]pyridines as potent inhibitors of AP-2-associated protein kinase 1 (AAK1) with antiviral activity

合成3-杂芳基-吡咯并 [2，3-b] 吡啶作为具有抗病毒活性的AP-2-associated蛋白激酶1 (AAK1) 的有效抑制剂

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
PRE
Ravi, Nitha Panikkassery; Van Eynde, Wout; Karim, Marwah; Tran, Do Hoang Nhu; Agrawal, Aditi; Schols, Dominique; Voet, Arnout; Einav, Shirit; Dehaen, Wim; De Jonghe, Steven
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-03-137
OA
Westberg, Michael; Su, Yichi; Zou, Xinzhi; Huang, Pinghan; Rustagi, Arjun; Garhyan, Jaishree; Patel, Puja Bhavesh; Fernandez, Daniel; Wu, Yan; Hao, Chenzhou; Lo, Chieh-Wen; Karim, Marwah; Ning, Lin; Beck, Aimee; Saenkham-Huntsinger, Panatda; Tat, Vivian; Drelich, Aleksandra; Peng, Bi-Hung; Einav, Shirit; Tseng, Chien-Te K.; Blish, Catherine; Lin, Michael Z.
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach
NATURE IMMUNOLOGY
IF27.6
2023-10-2311
PRE
Ghita, Luca; Yao, Zhiyuan; Xie, Yike; Duran, Veronica; Cagirici, Halise Busra; Samir, Jerome; Osman, Ilham; Rebellon-Sanchez, David Esteban; Agudelo-Rojas, Olga Lucia; Sanz, Ana Maria; Sahoo, Malaya Kumar; Robinson, Makeda L.; Gelvez-Ramirez, Rosa Margarita; Bueno, Nathalia; Luciani, Fabio; Pinsky, Benjamin A.; Montoya, Jose G.; Estupinan-Cardenas, Maria Isabel; Villar-Centeno, Luis Angel; Rojas-Garrido, Elsa Marina; Rosso, Fernando; Quake, Stephen R.; Zanini, Fabio; Einav, Shirit
Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics
SCIENCE ADVANCES
IF12.5
2023-03-248
OAAI
Robinson, Makeda L.; Glass, David R.; Duran, Veronica; Rojas, Olga Lucia Agudelo; Sanz, Ana Maria; Consuegra, Monika; Sahoo, Malaya Kumar; Hartmann, Felix J.; Bosse, Marc; Gelvez, Rosa Margarita; Bueno, Nathalia; Pinsky, Benjamin A.; Montoya, Jose G.; Maecker, Holden; Cardenas, Maria Isabel Estupinan; Centeno, Luis Angel Villar; Garrido, Elsa Marina Rojas; Rosso, Fernando; Bendall, Sean C.; Einav, Shirit
Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX
PLOS PATHOGENS
IF4.9
2022-08-1511
OAAI
Shirasaki, Takayoshi; Feng, Hui; Duyvesteyn, Helen M. E.; Fusco, William G.; McKnight, Kevin L.; Xie, Ling; Boyce, Mark; Kumar, Sathish; Barouch-Bentov, Rina; Gonzalez-Lopez, Olga; McNamara, Ryan; Wang, Li; Hertel-Wulff, Adriana; Chen, Xian; Einav, Shirit; Duncan, Joseph A.; Kapustina, Maryna; Fry, Elizabeth E.; Stuart, David, I; Lemon, Stanley M.

研究方向

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