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D

Denise Wootten

monash university
H指数:52
被引数:9,160

个人简介

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教育背景

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工作经历

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荣誉奖项

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De novo design of miniproteins targeting GPCRs

从头设计靶向GPCRs的迷你蛋白

Nature
IF48.5
2026-05-210
PRE
Edin Muratspahić; David Feldman; David E. Kim; Xiangli Qu; Ana-Maria Bratovianu; Paula Rivera-Sánchez; Jan Hendrik Voss; Emil P. T. Hertz; Mads Jeppesen; Federica Dimitri; Kensuke Sakamoto; Amrita Nallathambi; Pia Peceli; Jianjun Cao; Brian P. Cary; Matthew J. Belousoff; Peter Keov; Phuc N. H. Trinh; Qingchao Chen; Yue Ren; Justyn Fine; Sudha Mishra; Annu Dalal; Shachie Sinha; Ramanuj Banerjee; Manisankar Ganguly; Karthik Varappalayam Karuppusamy; Isaac Sappington; Thomas Schlichthaerle; Jason Z. Zhang; Arvind Pillai; Brian Coventry; Ljubica Mihaljević; Magnus Bauer; Susana Vázquez Torres; Amir Motmaen; Gyu Rie Lee; Long Tran; Xinru Wang; Inna Goreshnik; Dionne K. Vafeados; Justin E. Svendsen; Parisa Hosseinzadeh; Nicolai Lindegaard; Matthäus Brandt; Yann Waltenspühl; Kristine Deibler; Lukas Deweid; Anja Bennett; Jendrik Schöppe; Tiantang Dong; Xiaoli Yan; Luke Oostdyk; William Cao; Lakshmi Anantharaman; Johan J. Weisser; Jesper Frank Bastlund; Christoffer Bundgaard; Ayodeji A. Asuni; Justin G. English; Lance Stewart; Lauren Halloran; Jamie B. Spangler; André Lieber; Arun K. Shukla; Patrick M. Sexton; Bryan L. Roth; Brian E. Krumm; Denise Wootten; Christopher G. Tate; Christoffer Norn; David Baker
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
Science Advances
IF12.5
2026-02-040
OA
Liliane El Eid; Yusman Manchanda; Gregory Austin; Kieran Deane-Alder; Roxana-Maria Rujan; Zamara Mariam; Affiong I. Oqua; Matthew J. Belousoff; Jorge Bernardino de la Serna; Kyle W. Sloop; Guy A. Rutter; Alex Montoya; Dominic J. Withers; Steven J. Millership; Karim Bouzakri; Ben Jones; Christopher A. Reynolds; Patrick M. Sexton; Denise Wootten; Giuseppe Deganutti; Alejandra Tomas
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

476,326个体中随机葡萄糖的gis提供了对糖尿病病理生理学，并发症和治疗分层的见解

NATURE GENETICS
IF31.8
2023-09-0720
OAAI
Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; Gonzalez, Karla Sofia Gutierrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Magi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, He; Evangelou, Evangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Mueller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Correa, Ivan R., Jr.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, Andre G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Ines; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njolstad, Inger; Wichmann, H. -Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josee; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Xanomeline在M4 mAChR处显示伴随的正构和变构结合模式

NATURE COMMUNICATIONS
IF15.7
2023-09-0610
OAAI
Burger, Wessel A. C.; Pham, Vi; Vuckovic, Ziva; Powers, Alexander S.; Mobbs, Jesse I.; Laloudakis, Yianni; Glukhova, Alisa; Wootten, Denise; Tobin, Andrew B.; Sexton, Patrick M.; Paul, Steven M.; Felder, Christian C.; Danev, Radostin; Dror, Ron O.; Christopoulos, Arthur; Valant, Celine; Thal, David M.

研究方向

暂未获取到该数据
P
Patrick M. Sexton
H 指数:90论文数:1,733被引数:3.0万
A
Arthur Christopoulos
H 指数:95论文数:1,861被引数:4.1万
L
Laurence J. Miller
H 指数:0论文数:1被引数:16
S
Sebastian G. B. Furness
H 指数:30论文数:97被引数:3,882
P
Peishen Zhao
H 指数:27论文数:69被引数:3,171
C
Cassandra Koole
H 指数:21论文数:51被引数:2,173
J
John Simms
H 指数:31论文数:106被引数:3,481
R
Radostin Danev
H 指数:46论文数:156被引数:8,027
M
Matthew J. Belousoff
H 指数:39论文数:177被引数:4,145
C
Christopher A. Reynolds
H 指数:48论文数:252被引数:7,002