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J

Jaime Mella

universidad de valparaiso
H指数:18
被引数:813

个人简介

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工作经历

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荣誉奖项

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Evolution of Multitarget Strategies for Alzheimer’s Disease: From Cholinergic Inhibition to Network-Oriented Therapeutic Design (2006–2025)

阿尔茨海默病多靶点策略的演变：从胆碱能抑制到网络导向的药物治疗设计（2006—2025）

Pharmaceuticals
IF4.8
2026-08-140
OA
Jaime Mella; Alejandro Vega-Muñoz; Mauricio Soto; Daniel Moraga; Javier Campanini-Salinas; Eduardo Sandoval-Obando; Nicolás Contreras-Barraza; Guido Salazar-Sepúlveda; Natalia Salas-Guzmán; Remik Carabantes-Silva; Marco Mellado
Integrated computational modeling of chalcone-based inhibitors targeting carbonic anhydrase I and II: 3D-QSAR, molecular docking, and dynamics simulations

基于查尔酮类抑制剂的碳酸酐酶I和II靶向的整合计算建模：3D-QSAR、分子对接和动力学模拟

Journal of Computer-Aided Molecular Design
IF3.1
2026-05-140
PRE
Mauricio Soto; David Cabezas; Felipe Stambuk; Cesar González; Alison Acosta; Marcos Lorca; Luis Espinoza; Katy Díaz; Andrés F. Olea; Marco Mellado; Jaime Mella
Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder

结构导向的苯甲酸基TRPC6配体发现：综合对接、分子动力学和MM-GBSA构效关系研究：自闭症谱系障碍的潜在治疗分子

Pharmaceuticals
IF4.8
2026-03-030
OAAI
Nicolás Ignacio Silva; Gianfranco Sabadini; David Cabezas; Cristofer González; Paulina González; Jiao Luo; Cristian O. Salas; Marco Mellado; Marcos Lorca; Javier Romero-Parra; Jaime Mella
Design of Hybrid Quinoline–Chalcone Compounds Against Leishmania amazonensis Based on Computational Techniques: 2D- and 3D-QSAR with Experimental Validation

基于计算技术的针对利什曼原虫（Leishmania amazonensis）的杂合喹啉-查尔酮化合物设计：2D-和3D-QSAR与实验验证

Pharmaceuticals 2025, Vol. 18, Page 1567
IF0
2025-10-170
OAAI
Marcos Lorca; Gisela C. Muscia; Jaime Mella; Luciana Thomaz; Jenicer K. Yokoyama-Yasunaka; Daniel Moraga; Yeray A. Rodriguez-Nuñez; Silvia E. Asís; Mauro Cortez; Marco Mellado
Benzo[d]imidazole–Naphthalen-Arylmethanone Regioisomers as CB1 Ligands: Evaluation of Agonism via an Indirect Cytotoxicity-Based Approach

苯并[d]咪唑-萘基芳基甲酮同分异构体作为CB1配体：通过间接细胞毒性为基础的方法评估激动剂活性

International Journal of Molecular Sciences 2025, Vol. 26, Page 9986
IF0
2025-10-140
OAAI
Analia Young Hwa Cho; Renato Burgos Ravanal; Valeria Zuñiga Salazar; Marco Mellado; Marcos Lorca; David Pessoa-Mahana; Jaime Mella; Germán Günther Sapunar; Javier Romero-Parra
New Dimethoxyaryl-Sesquiterpene Derivatives with Cytotoxic Activity Against MCF-7 Breast Cancer Cells: From Synthesis to Topoisomerase I/II Inhibition and Cell Death Mechanism Studies

新型双甲氧基芳基-倍半萜衍生物及其对MCF-7乳腺癌细胞的细胞毒性活性：从合成到拓扑异构酶I/II抑制及细胞死亡机制研究

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
IF4.9
2025-05-090
OA
Araque, Ileana; Vergara, Rut; Mella, Jaime; Aranguiz, Pablo; Espinoza-Catalan, Luis; Salas, Cristian O.; Barrero, Alejandro F.; del Moral, Jose Quilez; Villena, Joan; Cuellar, Mauricio A.
Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands
MOLECULES
IF4.6
2020-10-107
OAAI
Cerda-Cavieres, Christopher; Quiroz, Gabriel; Iturriaga-Vasquez, Patricio; Rodriguez-Lavado, Julio; Alarcon-Esposito, Jazmin; Saitz, Claudio; Pessoa-Mahana, Carlos D.; Chung, Hery; Araya-Maturana, Ramiro; Mella-Raipan, Jaime; Cabezas, David; Ojeda-Gomez, Claudia; Reyes-Parada, Miguel; Pessoa-Mahana, Hernan
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2020-07-0119
PREAI
Rodriguez-Lavado, Julio; Gallardo-Garrido, Carlos; Mallea, Michael; Bustos, Victor; Osorio, Rodrigo; Hodar-Salazar, Martin; Chung, Hery; Araya-Maturana, Ramiro; Lorca, Marcos; David Pessoa-Mahana, C.; Mella-Raipan, Jaime; Saitz, Claudio; Jaque, Pablo; Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio; Pessoa-Mahana, Hernan

研究方向

暂未获取到该数据
M
Marco Mellado
H 指数:16论文数:69被引数:748
C
C. David Pessoa‐Mahana
H 指数:17论文数:70被引数:849
M
Marcos Lorca
H 指数:5论文数:14被引数:121
J
Javier Romero‐Parra
H 指数:10论文数:39被引数:352
C
Cristian O. Salas
H 指数:24论文数:138被引数:1,633
G
Gonzalo Recabarren‐Gajardo
H 指数:13论文数:38被引数:382
C
Carlos F. Lagos
H 指数:23论文数:89被引数:1,478
H
Hernán Pessoa‐Mahana
H 指数:17论文数:91被引数:836
C
Christian Espinosa‐Bustos
H 指数:16论文数:64被引数:647
P
Patricio Iturriaga‐Vásquez
H 指数:19论文数:71被引数:1,187