Le, Quy; Hadland, Brandon; Smith, Jenny L.; Leonti, Amanda; Huang, Benjamin J.; Ries, Rhonda; Hylkema, Tiffany A.; Castro, Sommer; Tang, Thao T.; Mckay, Cyd N.; Perkins, Lakeisha; Pardo, Laura; Sarthy, Jay; Beckman, Amy K.; Williams, Robin; Idemmili, Rhonda; Furlan, Scott; Ishida, Takashi; Call, Lindsey; Srivastava, Shivani; Loeb, Anisha M.; Milano, Filippo; Imren, Suzan; Morris, Shelli M.; Pakiam, Fiona; Olson, Jim M.; Loken, Michael R.; Brodersen, Lisa; Riddell, Stanley R.; Tarlock, Katherine; Bernstein, Irwin D.; Loeb, Keith R.; Meshinchi, Soheil

Chromatin as an old and new anticancer target

染色质作为一个新旧的抗癌靶点

TRENDS IN CANCER

IF17.5

2024-08-011

OAAI

Menin drives oncogenesis in Ewing sarcoma cells by activating transcription of key metastatic factors

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

IMMUNITY

IF26.3

2024-02-013

Jaeger-Ruckstuhl, Carla A.; Lo, Yun; Fulton, Elena; Waltner, Olivia G.; Shabaneh, Tamer B.; Simon, Sylvain; Muthuraman, Pranav V.; Correnti, Colin E.; Newsom, Oliver J.; Engstrom, Ian A.; Kanaan, Sami B.; Bhise, Shruti S.; Peralta, Jobelle M. C.; Ruff, Raymond; Price, Jason P.; Stull, Sylvia M.; Stevens, Andrew R.; Bugos, Grace; Kluesner, Mitchell G.; Voillet, Valentin; Muhunthan, Vishaka; Morrish, Fionnuala; Olson, James M.; Gottardo, Raphaeeurol; Sarthy, Jay F.; Henikoff, Steven; Sullivan, Lucas B.; Furlan, Scott N.; Riddell, Stanley R.

Targeting vulnerabilities arising from global DNA hypomethylation in cance

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-010

PRE

Oncohistone H2B-E76K alters gene expression & cellular phenotype in a bronchial epithelial cell line

CANCER RESEARCH

IF16.6

2023-04-040

PRE

Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

CANCER DISCOVERY

IF33.3

2022-11-1826

OAAI

De Sarkar, Navonil; Patton, Robert D.; Doebley, Anna-Lisa; Hanratty, Brian; Adil, Mohamed; Kreitzman, Adam J.; Sarthy, Jay F.; Ko, Minjeong; Brahma, Sandipan; Meers, Michael P.; Janssens, Derek H.; Ang, Lisa S.; Coleman, Ilsa M.; Bose, Arnab; Dumpit, Ruth F.; Lucas, Jared M.; Nunez, Talina A.; Nguyen, Holly M.; McClure, Heather M.; Pritchard, Colin C.; Schweizer, Michael T.; Morrissey, Colm; Choudhury, Atish D.; Baca, Sylvan C.; Berchuck, Jacob E.; Freedman, Matthew L.; Ahmad, Kami; Haffner, Michael C.; Montgomery, R. Bruce; Corey, Eva; Henikoff, Steven; Nelson, Peter S.; Ha, Gavin

CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-11-1522

OAAI

Le, Quy; Hadland, Brandon; Smith, Jenny L.; Leonti, Amanda; Huang, Benjamin J.; Ries, Rhonda; Hylkema, Tiffany A.; Castro, Sommer; Tang, Thao T.; McKay, Cyd N.; Perkins, LaKeisha; Pardo, Laura; Sarthy, Jay; Beckman, Amy K.; Williams, Robin; Idemmili, Rhonda; Furlan, Scott; Ishida, Takashi; Call, Lindsey; Srivastava, Shivani; Loeb, Anisha M.; Milano, Filippo; Imren, Suzan; Morris, Shelli M.; Pakiam, Fiona; Olson, Jim M.; Loken, Michael R.; Brodersen, Lisa; Riddell, Stanley R.; Tarlock, Katherine; Bernstein, Irwin D.; Loeb, Keith R.; Meshinchi, Soheil

dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region

CELL REPORTS

IF6.9

2022-03-0116

OAAI

Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

NATURE GENETICS

IF31.8

2021-10-1838

OAAI

Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression

NATURE BIOTECHNOLOGY

IF41.7

2021-04-12114

OAAI

Short H2A histone variants are expressed in cancer

NATURE COMMUNICATIONS

IF15.7

2021-01-2030

OAAI

Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naive diffuse midline glioma models

NEURO-ONCOLOGY

IF13.4

2020-11-0154

OAAI

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

组蛋白沉积途径决定了H3.1和H3.3 K27M癌基因的染色质景观

ELIFE

IF0

2020-09-0952

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

MYCN扩增和ATRX突变在神经母细胞瘤中不相容

NATURE COMMUNICATIONS

IF15.7

2020-02-1477

OAAI

Zeineldin, Maged; Federico, Sara; Chen, Xiang; Fan, Yiping; Xu, Beisi; Stewart, Elizabeth; Zhou, Xin; Jeon, Jongrye; Griffiths, Lyra; Nguyen, Rosa; Norrie, Jackie; Easton, John; Mulder, Heather; Yergeau, Donald; Liu, Yanling; Wu, Jianrong; Van Ryn, Collin; Naranjo, Arlene; Hogarty, Michael D.; Kaminski, Marcin M.; Valentine, Marc; Pruett-Miller, Shondra M.; Pappo, Alberto; Zhang, Jinghui; Clay, Michael R.; Bahrami, Armita; Vogel, Peter; Lee, Seungjae; Shelat, Anang; Sarthy, Jay F.; Meers, Michael P.; George, Rani E.; Mardis, Elaine R.; Wilson, Richard K.; Henikoff, Steven; Downing, James R.; Dyer, Michael A.

Jay F. Sarthy

个人简介

教育背景

工作经历

荣誉奖项

研究方向