Loi, Mervin; Lee, Jan Hau W.; Huh, Jimmy; Mallory, Palen; Napolitano, Natalie; Shults, Justine; Krawiec, Conrad; Shenoi, Asha; Polikoff, Lee; Al-Subu, Awni; Sanders Jr, Ronald; Toal, Megan; Branca, Aline; Glater-Welt, Lily; Ducharme-Crevier, Laurence; Breuer, Ryan; Parsons, Simon; Harwayne-Gidansky, Ilana; Kelly, Serena; Motomura, Makoto; Gladen, Kelsey; Pinto, Matthew; Giuliano Jr, John; Bysani, Gokul; Berkenbosch, John; Biagas, Katherine; Rehder, Kyle; Kasagi, Mioko; Lee, Anthony; Jung, Philipp; Shetty, Rakshay; Nadkarni, Vinay; Nishisaki, Akira

Enfortumab vedotin, a nectin-4-directed antibody-drug conjugate, demonstrates compelling antitumor activity in non-muscle invasive bladder cancer models which predicts minimal systemic exposure when administered by intravesical instillation in patients

CANCER RESEARCH

IF16.6

2023-04-140

PRE

Tucatinib does not alter oxaliplatin PK or associated renal function: An OCT2 and MATE transport inhibition study

CANCER RESEARCH

IF16.6

2023-04-040

PRE

Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases

CLINICAL CANCER RESEARCH

IF10.2

2022-05-1813

OAAI

Risk-Based Pharmacokinetic and Drug-Drug Interaction Characterization of Antibody-Drug Conjugates in Oncology Clinical Development: An International Consortium for Innovation and Quality in Pharmaceutical Development Perspective

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2021-11-2314

PREAI

Physiologically based pharmacokinetic (PBPK) modeling of the central nervous system (CNS) pharmacokinetics of tucatinib in patients with breast cancer brain metastasis

ANNALS OF ONCOLOGY

IF65.4

2020-09-015

OAAI

Tucatinib inhibits CYP3A, CYP2C8 and P-gp-mediated elimination and is impacted by CYP2C8 inhibition in healthy volunteers

CANCER RESEARCH

IF16.6

2020-08-152

PRE

Tucatinib inhibits creatinine and metformin renal tubule secretion but has no effect on renal function (GFR)

CANCER RESEARCH

IF16.6

2020-08-150

PRE

Assessment of an Unplanned Extubation Bundle to Reduce Unplanned Extubations in Critically Ill Neonates, Infants, and Children

JAMA PEDIATRICS

IF18

2020-06-0156

OAAI

4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage

SCIENTIFIC REPORTS

IF3.9

2020-04-2919

OAAI

Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events

CRITICAL CARE MEDICINE

IF6

2020-04-1721

PREAI

Conway, J. Arden; Kharayat, Priyanka; Sanders, Ronald C., Jr.; Nett, Sholeen; Weiss, Scott L.; Edwards, Lauren R.; Breuer, Ryan; Kirby, Aileen; Krawiec, Conrad; Page-Goertz, Christopher; Polikoff, Lee; Turner, David A.; Shults, Justine; Giuliano, John S., Jr.; Orioles, Alberto; Balkandier, Sylvain; Emeriaud, Guillaume; Rehder, Kyle J.; Boon, Joel Lim Kian; Shenoi, Asha; Vanderford, Paula; Nuthall, Gabrielle; Lee, Anthony; Zeqo, Jonida; Parsons, Simon J.; Furlong-Dillard, Jamie; Meyer, Keith; Harwayne-Gidansky, Ilana; Jung, Philipp; Adu-Darko, Michelle; Bysani, G. Kris; McCarthy, Melissa A.; Shlomovich, Mark; Toedt-Pingel, Iris; Branca, Aline; Esperanza, Maria Christina; Al-Subu, Awni M.; Pinto, Matthew; Tallent, Sarah; Shetty, Rakshay; Thyagarajan, Sujatha; Ikeyama, Takanari; Tarquinio, Keiko M.; Skippen, Peter; Kasagi, Mioko; Howell, Joy D.; Nadkarni, Vinay; Nishisaki, Akira

Current and future treatments for tuberculosis

BMJ-BRITISH MEDICAL JOURNAL

IF42.7

2020-03-0254

PREAI

Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases

儿童肥胖和成人心脏代谢疾病的共同遗传基础

HUMAN GENOMICS

IF4.3

2019-04-0417

OAAI

Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine