Raphael Kopan - Publications, H-index & Citations

Raphael Kopan

pediatrics

87H指数

254论文数

3.3W被引数

收录论文 103

发表时间

Single cell RNA sequencing reveals transitional states and signaling shifts in nephron progenitor cells of the late-gestation rhesus macaque kidney 单细胞RNA测序揭示晚期妊娠恒河猴肾脏肾单位祖细胞的过渡状态和信号转变

BMC Genomics

IF3.7

2026-05-04

OAAI

Kairavee Thakkar; Sunitha Yarlagadda; Lyan Alkhudairy; Andrew Potter; Konrad Thorner; Praneet Chaturvedi; Cristina Cebrian; Kyle W. McCracken; Nathan Salomonis; Raphael Kopan; Meredith P. Schuh

Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver 内皮细胞中缺陷的Notch1信号通路驱动了Adams-Oliver综合征小鼠模型的病理发生。

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-12-01

OAAI

Solano, Alyssa F.; Preusse, Kristina; Cain, Brittany; Hotz, Rebecca; Gavini, Parthav; Yuan, Zhenyu; Bowen, Benjamin; Maco, Gabrielle; Neal, Hope; Gagliani, Ellen K.; Ahn, Christopher; Lim, Hee-Woong; Southgate, Laura; Kovall, Rhett A.; Kopan, Raphael; Gebelein, Brian

Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud 通过将远端肾小管与输尿管芽融合，将收集系统整合到人类肾类器官中

Cell Stem Cell

IF20.4

2025-05-08

PREAI

Min Shi; Brittney Crouse; Nambirajan Sundaram; Naomi Pode Shakked; Konrad Thorner; Nathaniel M. King; Parna Dutta; Lioba Ester; Weitao Zhang; Vinothini Govindarajah; Raphael Kopan; Cristina Cebrian; Christopher N. Mayhew; Michael A. Helmrath; Joseph V. Bonventre; Kyle W. McCracken

The unique functions of Runx1 in skeletal muscle maintenance and regeneration are facilitated by an ETS interaction domain

DEVELOPMENT

IF3.6

2024-12-12

OAAI

Yu, Meng; Thorner, Konrad; Parameswaran, Sreeja; Wei, Wei; Yu, Chuyue; Lin, Xinhua; Kopan, Raphael; Hass, Matthew R.

RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis

NATURE COMMUNICATIONS

IF15.7

2023-12-09

OAAI

Pode-Shakked, Naomi; Slack, Megan; Sundaram, Nambirajan; Schreiber, Ruth; McCracken, Kyle W.; Dekel, Benjamin; Helmrath, Michael; Kopan, Raphael

Characterizing post-branching nephrogenesis in the neonatal rabbit

SCIENTIFIC REPORTS

IF3.9

2023-11-06

OAAI

Schuh, Meredith P.; Yarlagadda, Sunitha; Alkhudairy, Lyan; Preusse, Kristina; Kopan, Raphael

Regulation of nephron progenitor cell lifespan and nephron endowment

NATURE REVIEWS NEPHROLOGY

IF39.8

2022-09-14

OAAI

Perl, Alison J.; Schuh, Meredith P.; Kopan, Raphael

Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis

DEVELOPMENT

IF3.6

2022-05-16

OAAI

Duvall, Kathryn; Crist, Lauren; Perl, Alison J.; Shakked, Naomi Pode; Chaturvedi, Praneet; Kopan, Raphael

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

SCIENTIFIC REPORTS

IF3.9

2022-01-31

OAAI

Swaminathan, Bhairavi; Youn, Seock-Won; Naiche, L. A.; Du, Jing; Villa, Stephanie R.; Metz, Jordan B.; Feng, Huijuan; Zhang, Chaolin; Kopan, Raphael; Sims, Peter A.; Kitajewski, Jan K.

TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2022-01-01

OAAI

Murrison, Liza Bronner; Ren, Xiaomeng; Preusse, Kristina; He, Hua; Kroner, John; Chen, Xiaoting; Jenkins, Seth; Johansson, Elisabet; Biagini, Jocelyn M.; Weirauch, Matthew T.; Kopan, Raphael; Martin, Lisa J.; Hershey, Gurjit K. Khurana

Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis 由Tsc1协调的祖细胞翻译体变化增加了对Wnt信号的感知以终止肾发生

NATURE COMMUNICATIONS

IF15.7

2021-11-03

OAAI

Jarmas, Alison E.; Brunskill, Eric W.; Chaturvedi, Praneet; Salomonis, Nathan; Kopan, Raphael

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

PLOS GENETICS

IF3.7

2021-09-24

OAAI

Kuang, Yi; Pyo, Anna; Eafergan, Natanel; Cain, Brittany; Gutzwiller, Lisa M.; Axelrod, Ofri; Gagliani, Ellen K.; Weirauch, Matthew T.; Kopan, Raphael; Kovall, Rhett A.; Sprinzak, David; Gebelein, Brian

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

PLOS GENETICS

IF3.7

2021-06-10

OAAI

Hass, Matthew R.; Brissette, Daniel; Parameswaran, Sreeja; Pujato, Mario; Donmez, Omer; Kottyan, Leah C.; Weirauch, Matthew T.; Kopan, Raphael

Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis

FASEB JOURNAL

IF4.2

2020-05-31

OAAI

Mukherjeel, Malini; Ratnayake, Ishara; Janga, Madhusudhana; Fogarty, Eric; Scheidt, Shania; Grassmeyer, Justin; DeRiso, Jennifer; Chandrasekar, Indra; Ahrenkiel, S. Phil; Kopan, Raphael; Surendran, Kameswaran

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

ELIFE

IF0

2020-04-16

OAAI

Yi Kuang; Golan, Ohad; Preusse, Kristina; Cain, Brittany; Christensen, Collin J.; Salomone, Joseph; Campbell, Ian; Okwubido-Williams, FearGod, V; Hass, Matthew R.; Yuan, Zhenyu; Eafergan, Nathanel; Moberg, Kenneth H.; Kovall, Rhett A.; Kopan, Raphael; Sprinzak, David; Gebelein, Brian

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

DEVELOPMENTAL CELL

IF8.7

2020-03-01

OAAI

Seymour, Philip Allan; Collin, Caitlin Alexis; Egeskov-Madsen, Anuska la Rosa; Jorgensen, Mette Christine; Shimojo, Hiromi; Imayoshi, Itaru; de Lichtenberg, Kristian Honnens; Kopan, Raphael; Kageyama, Ryoichiro; Serup, Palle

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-05-21

OAAI

Volovelsky, Oded; Thi Nguyen; Jarmas, Alison E.; Combes, Alexander N.; Wilson, Sean B.; Little, Melissa H.; Witte, David P.; Brunskill, Eric W.; Kopan, Raphael

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number

KIDNEY INTERNATIONAL

IF12.6

2018-03-01

OAAI

Combes, Alexander N.; Wilson, Sean; Phipson, Belinda; Binnie, Brandon B.; Ju, Adler; Lawlor, Kynan T.; Cebrian, Cristina; Walton, Sarah L.; Smyth, Ian M.; Moritz, Karen M.; Kopan, Raphael; Oshlack, Alicia; Little, Melissa H.

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling

ANGIOGENESIS

IF9.2

2018-02-03

OAAI

Farber, Gregory; Hurtado, Romulo; Loh, Sarah; Monette, Sebastien; Mtui, James; Kopan, Raphael; Quaggin, Susan; Meyer-Schwesinger, Catherine; Herzlinger, Doris; Scott, Rizaldy P.; Blobel, Carl P.

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force

DEVELOPMENTAL CELL

IF8.7

2017-05-01

306

OAAI

Kovall, Rhett A.; Gebelein, Brian; Sprinzak, David; Kopan, Raphael

研究方向