João F. Passos - Publications, H-index & Citations

João F. Passos

Department of Physiology and Biomedical Engineering

68H指数

199论文数

3.0W被引数

收录论文 107

发表时间

Inhibiting cyclin D1–CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline 抑制cyclin D1–CDK6可抑制衰老相关炎症基因表达和年龄相关功能下降

Nature Aging

IF19.4

2026-08-20

PREAI

Adarsh Rajesh; Aaron P. Havas; Rouven Arnold; Kathryn Lande; Xue Lei; Kelly Yichen Li; Armin Gandhi; Ana Catarina Franco; Seung-Hwa Woo; Anthony B. Lagnado; Angela Liou; K. Garrett Evensen; Linshan Laux; Maggie Klaers; Jake Kircher; Amirhossein Nayeri Rad; Hiroshi Tanaka; Marcos Garcia Teneche; Michael Alcaraz; Karl N. Miller; Zoe Yao; Sviatlana Zaretski; Sainath Mamde; Qian Yang; Jessica Proulx; Andrew Davis; Laurence Haddadin; Carolina Cano Macip; Brightany Li; Nirmalya Dasgupta; Zong Ming Chua; Cedomir Stamenkovic; Gabriele Guarnaccia; Hideki Tanizawa; Charlene Miciano; Elizabeth Smoot; Allen Wang; Rebecca A. Porritt; Alessandra Sacco; Ken-ichi Noma; Jeffrey H. Albrecht; Laura J Niedernhofer; Joao F Passos; April E. Williams; Bing Ren; Kevin Y. Yip; Peter D. Adams

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells 衰老诱导的肝细胞CD44驱动与邻近T细胞功能障碍相关的IL6/STAT3信号通路

npj Aging

IF6

2026-08-13

OAAI

Armin Gandhi; Kathryn Lande; Kelly Yichen Li; Filipe A. Hoffmann; Michael LaPorte; Shirong Tan; K. Garrett Evensen; Benji Portillo; Marcos Garcia Teneche; Rouven Arnold; Adarsh Rajesh; Jessica Proulx; Shanshan Yin; Aaron Havas; Angela Liou; Allen Lee; Helene Martini; Xue Lei; Charlene Miciano; Qian Yang; Elizabeth W. Smoot; Sainath Mamde; Andrew Davis; Rebecca Porritt; Alessandra Sacco; João F. Passos; Kevin M. Tharp; Kevin Yip; Allen Wang; Bing Ren; April Williams; Susan Kaech; Peter D. Adams

Senotypes define the diverse landscape of senescent cells 衰老细胞表型定义了衰老细胞的多样性景观

Nature Aging

IF19.4

2026-07-29

PREAI

Marissa J. Schafer; Nathan Basisty; Ann V. Hertzel; Alexandra N. Rindone; Jennifer H. Elisseeff; Vidyani Suryadevara; Constantin Aliferis; Paul D. Robbins; Laura J. Niedernhofer; Karl N. Miller; Peter D. Adams; Vilas Menon; Hemali Phatnani; Joao F. Passos; Birgit Schilling; Simon Melov; Nicola Neretti; Darren J. Baker

Mitochondrial metabolism and epigenetic crosstalk drive SASP 线粒体代谢与表观遗传学串扰驱动SASP

Nature

IF48.5

2026-07-29

OAAI

Hélène Martini; Jodie Birch; Francisco D. M. Marques; Stella Victorelli; Anthony B. Lagnado; Nicholas Pirius; Ana Catarina Franco; Gung Lee; Yeaeun Han; Jennifer L. Rowsey; Wazim Mohammed Ismail; Amelia Mazzone; Tianna M. Espe; Taro Hitosugi; Ya Li; Alexander M. Washington; Aaron Havas; Rabi Murad; Xue Lei; Rebecca A. Porritt; Oliver D. K. Maddocks; Jair Machado Espindola-Netto; Dominik Saul; Sundeep Khosla; Diana Jurk; Enis Kostallari; Alexandre Gaspar-Maia; Peter D. Adams; João F. Passos

Mitochondrial RNA cytosolic leakage drives the SASP 线粒体RNA的胞质泄漏驱动SASP

Nature Communications

IF15.7

2025-12-15

OAAI

Stella Victorelli; Madeline Eppard; Hélène Martini; Seung-Hwa Woo; Stacia P. A. Everts; Gung Lee; Nicholas Pirius; Nuan Han; Eugene Y. Liang; Ana Catarina Franco; Yeaeun Han; Dominik Saul; Eva Nóvoa; Rubén Nogueiras; Patrick L. Splinter; Steven P. O’Hara; Olivia Morgenthaler; Lucía Valenzuela-Pérez; Hyun Se Kim Lee; Diana Jurk; Nicholas F. LaRusso; Petra Hirsova; João F. Passos

Advancing biological understanding of cellular senescence with computational multiomics 通过计算多组学推进对细胞衰老的生物学理解

Nature Genetics

IF0

2025-09-15

PREAI

Sheng Li; Paula A. Agudelo Garcia; Constantin Aliferis; Michael J. Becich; Jazmin Calyeca; Benjamin D. Cosgrove; Jennifer Elisseeff; Negin Farzad; Elana J. Fertig; Carolyn Glass; Liangcai Gu; Qianjiang Hu; Zhicheng Ji; Melanie Königshoff; Nathan K. LeBrasseur; Dongmei Li; Anjun Ma; Qin Ma; Vilas Menon; Jacob T. Mitchell; Ana L. Mora; Sushma Nagaraj; Andrew C. Nelson; Laura J. Niedernhofer; Mauricio Rojas; Hash Brown Taha; Jinhua Wang; Siyuan Wang; Pei-Hsun Wu; Jichun Xie; Ming Xu; Miao Yu; Xu Zhang; Yue Zhao; Peter D. Adams; Cristina Aguayo-Mazzucato; Darren J. Baker; Christopher Benz; David A. Bernlohr; Marta Bueno; Jin Chen; Bennett G. Childs; Jeffrey H. Chuang; Dongjun Chung; Mythili Dileepan; Li Ding; Mingze Dong; Francesca Duncan; Archibald Enninful; William F. Flynn; Ana Catarina Franco; David Furman; Vesna Garovic; Stephanie Halene; Allison B. Herman; Ann V. Hertzel; Kanako Iwasaki; Hyeongseon Jeon; Jeon Woong Kang; Shilpita Karmakar; James L. Kirkland; Ron Korstanje; Erich Kummerfeld; Jun Hee Lee; Yang Liu; Yao Lu; Jose Lugo-Martinez; Helene Martini; Simon Melov; Nicolas Musi; João F. Passos; Samuel T. Peters; Irfan Rahman; Ramalakshmi Ramasamy; Alexandra N. Rindone; Paul D. Robbins; Paul Robson; Jhonny Rodriguez-Lopez; Lorena Rosas; Nadia Rosenthal; Marissa J. Schafer; Birgit Schilling; Elizabeth L. Schmidt; Kevin Schneider; Kaustav Sengupta; Jian Shu; Peter T. C. So; Li Sun; Tamar Tchkonia; Marcos G. Teneche; Natalia Vanegas; Julia Wang; Juan Xie; Shanshan Yin; Ke Zhang; Quan Zhu; Rong Fan

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells 组蛋白分子伴侣HIRA失活揭示了黑色素细胞前体正常胚胎发育与成体黑色素细胞干细胞维持之间的联系

AGING CELL

IF7.1

2025-05-14

OAAI

Jaber-Hijazi, F; Arnold, R; Swaminathan, K; Gilroy, K; Wenzel, AT; Lagnado, A; Kirschner, K; Robertson, N; Reid, C; Fullarton, N; Pawlikowski, J; Rai, TS; Baranyk, I; Shi, CH; Yip, KY; Blyth, K; Mesirov, JP; Harris, ML; Passos, JF; Machesky, LM; Adams, PD

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells p53增强DNA修复，并抑制衰老细胞中的细胞质染色质片段和炎症。

NATURE COMMUNICATIONS

IF15.7

2025-03-05

OAAI

Miller, Karl N.; Li, Brightany; Pierce-Hoffman, Hannah R.; Patel, Shreeya; Lei, Xue; Rajesh, Adarsh; Teneche, Marcos G.; Havas, Aaron P.; Gandhi, Armin; Macip, Carolina Cano; Lyu, Jun; Victorelli, Stella G.; Woo, Seung-Hwa; Lagnado, Anthony B.; Laporta, Michael A.; Liu, Tianhui; Dasgupta, Nirmalya; Li, Sha; Davis, Andrew; Korotkov, Anatoly; Hultenius, Erik; Gao, Zichen; Altman, Yoav; Porritt, Rebecca A.; Garcia, Guillermina; Mogler, Carolin; Seluanov, Andrei; Gorbunova, Vera; Kaech, Susan M.; Tian, Xiao; Dou, Zhixun; Chen, Chongyi; Passos, Joao F.; Adams, Peter D.

NEW INSIGHTS INTO MITOCHONDRIA AND CELLULAR SENESCENCE 线粒体和细胞衰老的新见解

INNOVATION IN AGING

IF4.3

2024-12-31

OAAI

Passos, Joao

CELL SENESCENCE AND MITOCHONDRIA: A MATTER OF LIFE OR DEATH 细胞衰老与线粒体：生死攸关的问题

INNOVATION IN AGING

IF4.3

2024-12-31

OAAI

Passos, Joao

Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline 皮肤衰老细胞移植诱导与年龄相关的外周功能障碍和认知功能下降

AGING CELL

IF7.1

2024-10-07

OAAI

Franco, Ana Catarina; Martini, Helene; Victorelli, Stella; Lagnado, Anthony B.; Wyles, Saranya P.; Rowsey, Jennifer L.; Pirius, Nicholas; Woo, Seung-Hwa; Costa, Daniela G.; Chaib, Selim; Tullius, Stefan G.; Tchkonia, Tamar; Kirkland, James L.; Khosla, Sundeep; Jurk, Diana; Cavadas, Claudia; Passos, Joao F.

SenNet recommendations for detecting senescent cells in different tissues SenNet建议检测不同组织中的衰老细胞

NATURE REVIEWS MOLECULAR CELL BIOLOGY

IF90.2

2024-06-03

PREAI

Suryadevara, Vidyani; Hudgins, Adam D.; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K.; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M.; Aguayo-Mazzucato, Cristina; Baker, Darren J.; Bernlohr, David A.; Jurk, Diana; Mangarova, Dilyana B.; Quardokus, Ellen M.; Enninga, Elizabeth Ann L.; Schmidt, Elizabeth L.; Chen, Feng; Duncan, Francesca E.; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A.; Lee, Gung; Daldrup-Link, Heike E.; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M.; Rahman, Irfan; Nie, Jia; Passos, Joao F.; Silverstein, Jonathan C.; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J.; Ding, Li; Wang, Lichao; Adams, Lisa C.; Ruiyang, Liu; Doolittle, Madison L.; Teneche, Marcos G.; Schafer, Marissa J.; Xu, Ming; Hajipour, Mohammadjavad; Boroumand, Mozhgan; Basisty, Nathan; Sloan, Nicholas; Slavov, Nikolai; Kuksenko, Olena; Robson, Paul; Gomez, Paul T.; Vasilikos, Periklis; Adams, Peter D.; Carapeto, Priscila; Zhu, Quan; Ramasamy, Ramalakshmi; Perez-Lorenzo, Rolando; Fan, Rong; Dong, Runze; Montgomery, Ruth R.; Shaikh, Sadiya; Vickovic, Sanja; Yin, Shanshan; Kang, Shoukai; Suvakov, Sonja; Khosla, Sundeep; Garovic, Vesna D.; Menon, Vilas; Xu, Yanxin; Song, Yizhe; Suh, Yousin; Dou, Zhixun; Neretti, Nicola

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-05-16

OAAI

Saul, Dominik; Doolittle, Madison L.; Rowsey, Jennifer L.; Froemming, Mitchell N.; Kosinsky, Robyn L.; Vos, Stephanie J.; Ruan, Ming; LeBrasseur, Nathan K.; Chandra, Abhishek; Pignolo, Robert J.; Passos, Joao F.; Farr, Joshua N.; Monroe, David G.; Khosla, Sundeep

Telomeres, cellular senescence, and aging: past and future 端粒，细胞衰老和衰老: 过去和未来

BIOGERONTOLOGY

IF4.1

2023-12-27

OAAI

Eppard, Madeline; Passos, Joao F.; Victorelli, Stella

COPIng with senescence

NATURE CELL BIOLOGY

IF19.1

2023-11-27

PREAI

Victorelli, Stella; Passos, Joao F.

New Horizons in cellular senescence for clinicians 临床医生细胞衰老的新视野

AGE AND AGEING

IF7.1

2023-07-15

OAAI

Witham, Miles D.; Granic, Antoneta; Miwa, Satomi; Passos, Joao F.; Richardson, Gavin D.; Sayer, Avan A.

Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study 确定表征人类骨骼肌细胞衰老的可行性并探索与不同年龄的肌肉形态和身体功能的关联: MASS_Lifecourse研究的发现

GEROSCIENCE

IF5.4

2023-07-11

OAAI

Habiballa, Leena; Hruby, Adam; Granic, Antoneta; Dodds, Richard M.; Hillman, Susan J.; Jurk, Diana; Passos, Joao F.; Sayer, Avan A.

Spatial mapping of cellular senescence: emerging challenges and opportunities 细胞衰老的空间图谱: 新出现的挑战和机遇

NATURE AGING

IF19.4

2023-07-03

OAAI

Gurkar, Aditi U.; Gerencser, Akos A.; Mora, Ana L.; Nelson, Andrew C.; Zhang, Anru R.; Lagnado, Anthony B.; Enninful, Archibald; Benz, Christopher; Furman, David; Beaulieu, Delphine; Jurk, Diana; Thompson, Elizabeth L.; Wu, Fei; Rodriguez, Fernanda; Barthel, Grant; Chen, Hao; Phatnani, Hemali; Heckenbach, Indra; Chuang, Jeffrey H.; Horrell, Jeremy; Petrescu, Joana; Alder, Jonathan K.; Lee, Jun Hee; Niedernhofer, Laura J.; Kumar, Manoj; Konigshoff, Melanie; Bueno, Marta; Sokka, Miiko; Scheibye-Knudsen, Morten; Neretti, Nicola; Eickelberg, Oliver; Adams, Peter D.; Hu, Qianjiang; Zhu, Quan; Porritt, Rebecca A.; Dong, Runze; Peters, Samuel; Victorelli, Stella; Pengo, Thomas; Khaliullin, Timur; Suryadevara, Vidyani; Fu, Xiaonan; Bar-Joseph, Ziv; Ji, Zhicheng; Passos, Joao F.

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction (vol 9, 15, 2023)

NPJ AGING

IF6

2023-06-23

OAAI

Redgrave, Rachael E. E.; Dookun, Emily; Booth, Laura K. K.; Encina, Maria Camacho; Folaranmi, Omowumi; Tual-Chalot, Simon; Gill, Jason H. H.; Owens, W. Andrew; Spyridopoulos, Ioakim; Passos, Joao F.; Richardson, Gavin D. D.

Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

NPJ AGING

IF6

2023-06-14

OAAI

Redgrave, Rachael E.; Dookun, Emily; Booth, Laura K.; Encina, Maria Camacho; Folaranmi, Omowumi; Tual-Chalot, Simon; Gill, Jason H.; Owens, W. Andrew; Spyridopoulos, Ioakim; Passos, Joao F.; Richardson, Gavin D.

研究方向