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G

Giedre Krenciute

St Jude Children's Research Hospital
H指数:27
被引数:4,151

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Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma

靶向B7-H3-CAR T细胞中的Regnase-1重编程肿瘤微环境并增强对骨肉瘤的抗肿瘤功效

Cell Reports Medicine
IF10.6
2026-09-010
PRE
Adeshakin, Adeleye O.; Shi, Hao; Perry, S. Scott; Sheppard, Heather; Nguyen, Phuong; Sun, Xiang; Zhou, Peipei; Metais, Jean-Yves; Cunningham, Trevor; Anil, K. C.; Tian, Liqing; Peche, Vivek; Prater, Mollie S.; Langfitt, Deanna M.; O'Reilly, Carla; Park, Jeoungeun J.; Chabot, Ashley; Zhou, Sheng; Matsubara, Azusa; Lee, GaHyun; Tsai, Shengdar Q.; Pruett-Miller, Shondra M.; Talbot, Lindsay J.; Yustein, Jason T.; Krenciute, Giedre; DeRenzo, Christopher; Chi, Hongbo; Gottschalk, Stephen
Author Correction: cBAF complex components and MYC cooperate early in CD8+ T cell fate

作者更正：cBAF 复合体组分和 MYC 在 CD8+ T 细胞命运决定早期协同作用

Nature
IF48.5
2026-06-240
PRE
Ao Guo; Hongling Huang; Zhexin Zhu; Mark J. Chen; Hao Shi; Sujing Yuan; Piyush Sharma; Jon P. Connelly; Swantje Liedmann; Yogesh Dhungana; Zhenrui Li; Dalia Haydar; Mao Yang; Helen Beere; Jason T. Yustein; Christopher DeRenzo; Shondra M. Pruett-Miller; Jeremy Chase Crawford; Giedre Krenciute; Charles W. M. Roberts; Hongbo Chi; Douglas R. Green
Computationally structurally optimized IL13Rα2-B7-H3 tandem CAR T cells overcome antigen-heterogeneity mediated tumor escape in a brain tumor model

计算结构优化的IL13Rα2-B7-H3串联CAR-T细胞克服了抗原异质性介导的肿瘤逃逸，在脑肿瘤模型中。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Meehl, Michaela M.; Immadisetty, Kalyan; Trivedi, Vikas D.; Glowacki, Pawel; Prinzing, Brooke; Anido, Alejandro Allo; Ibanez-Vega, Jorge; Leslie, Benjamin J.; Babu, Mohan Madan; Krenciute, Giedre
Increased capacity for expansion, not persistence, improves preclinical B7-H3 targeted CAR T cell therapy against aggressive Group 3 medulloblastomas

扩增能力而非持久性增强，可改善针对侵袭性Group 3髓母细胞瘤的B7-H3靶向CAR T细胞疗法的前临床效果

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Ward, Meghan; Meehl, Michaela; Senaoui, Linda; Park, Jeoungeun John; Ibanez-Vega, Jorge; Dovidonyte, Rugile; Kujur, Weshely; Zhou, Sheng; Bertrand, Kelsey; Derenzo, Christopher; Gottschalk, Stephen; Roussel, Martine; Youngblood, Benjamin; Chi, Hongbo; Krenciute, Giedre
CELL-FREE DNA ANALYSIS OF CSF SAMPLES ENABLES ASSESSMENT OF TREATMENT RESPONSE AND TRACKING OF CAR T-CELLS POST-LOCOREGIONAL DELIVERY IN PEDIATRIC BRAIN TUMOR PATIENTS

脑脊液样本的无细胞DNA分析能够评估治疗反应，并追踪在儿科脑肿瘤患者中局部区域给药后的CAR T细胞。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Kostecka, Anna; Smith, Kyle S.; Han, Katie; Martin, Vincentius; Lin, Hong; Langfitt, Deanna; Ward, Meghan B.; Walhart, Tara; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher; Bertrand, Kelsey C.; Northcott, Paul A.
Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial

局部区域B7-H3 CAR-T细胞治疗复发/难治性中枢神经系统肿瘤：Loc3CAR试验的初步临床经验

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Bertrand, Kelsey; Hanzlik, Emily; Chiang, Jason; Pinto, Soniya; Selukar, Subodh; Kosteka, Anna; Smith, Kyle; Han, Katie; Ibanez, Jorge; Tlais, Dana; Orr, Brent; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugmam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Crawford, Jeremy; Robinson, Giles; Park, Julie; Northcott, Paul; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher
Tumor inflammation-associated neurotoxicities for patients treated with intracranial B7-H3-CAR T cells on a phase I clinical trial

I期临床试验中接受颅内B7-H3-CAR T细胞治疗的患者的肿瘤炎症相关神经毒性

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Hanzlik, Emily M.; Bertrand, Kelsey C.; Chiang, Jason; Pinto, Soniya; Khan, Raja B.; Solanki, Arun; Selukar, Subodh; Wang, Yu; Bakare, Deborah; Swartz, Kate; Gajjar, Amar; Robinson, Giles W.; Park, Julie R.; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher
Early methionine availability attenuates T cell exhaustion

早期蛋氨酸利用减弱t 细胞耗竭

Nature Immunology
IF27.6
2025-07-230
OA
Piyush Sharma; Ao Guo; Suresh Poudel; Emilio Boada-Romero; Katherine C. Verbist; Gustavo Palacios; Kalyan Immadisetty; Mark J. Chen; Dalia Haydar; Ashutosh Mishra; Junmin Peng; M. Madan Babu; Giedre Krenciute; Evan S. Glazer; Douglas R. Green

研究方向

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S
Stephen Gottschalk
H 指数:77论文数:695被引数:2.1万
J
Jorge Ibañez-Vega
H 指数:16论文数:141被引数:916
D
Dalia Haydar
H 指数:14论文数:120被引数:1,410
M
Michaela Meehl
H 指数:3论文数:100被引数:50
M
Meghan B Ward
H 指数:3论文数:28被引数:38
H
Haley Houke
H 指数:5论文数:24被引数:543
C
Christopher DeRenzo
H 指数:18论文数:117被引数:1,511
S
Stephen C. Mack
H 指数:61论文数:529被引数:1.8万
D
Deanna Langfitt
H 指数:14论文数:156被引数:1,100
M
Martine F. Roussel
H 指数:96论文数:653被引数:3.7万