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Zhixun Dou

massachusetts general hospital
H指数:31
被引数:7,304

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RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

拉曼组学解码衰老与修复过程中衰老的空间振动-分子结构

Nature Aging
IF19.4
2026-09-210
OAAI
Ke Zhang; Xingjian Chen; Francesco Monticolo; Salvatore Sorrentino; Haochun Huang; Claire Callahan; Yueqing Qiao; Judy Zhou; Sonia Brodowska; Styliani Sapantzi; Jianhuan Qi; Yinghan Wu; Thai Nam Son Dang; Yanwan Cao; Sumin Kang; Francesca Viggiani; Chia-Kang Ho; Yanxin Xu; Koseki J. Kobayashi-Kirschvink; Thang Mung; Hemali Phatnani; Zhixun Dou; Jeon Woong Kang; Peter T. C. So; Jian Shu
OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

OGFOD1通过调控蛋白质合成使急性髓系白血病（AML）具有化疗和营养应激抗性。

Cell Metabolism
IF30.9
2025-09-160
PRE
Christina Mayerhofer; Dan Li; Trine Kristiansen; Ernst Mayerhofer; Azeem Sharda; Giulia Schiroli; Karin Gustafsson; Lingli He; Michael Mazzola; Sam Keyes; Anna Kiem; Eve Crompton; Yanxin Xu; Sovannarith Korm; Zhixun Dou; Charles Vidoudez; Peter G. Miller; Nick van Gastel; Timothy A. Graubert; David T. Scadden
WSTF nuclear autophagy regulates chronic but not acute inflammation

WSTF核自噬调节慢性而非急性炎症

Nature
IF48.5
2025-07-020
PRE
Yu Wang; Vinay V. Eapen; Yaosi Liang; Athanasios Kournoutis; Marc Samuel Sherman; Yanxin Xu; Angelique Onorati; Xianting Li; Xiaoting Zhou; Kathleen E. Corey; Kuo Du; Ana Maria Cabral Burkard; Chia-Kang Ho; Jing Xie; Hui Zhang; Raquel Maeso-Díaz; Xinyi Ma; Ulrike Rieprecht; Tara O’Brien; Murat Cetinbas; Lu Wang; Jihe Liu; Corey Bretz; Aaron P. Havas; Zhuo Zhou; Shannan J. Ho Sui; Srinivas Vinod Saladi; Ruslan I. Sadreyev; Peter D. Adams; Robert E. Kingston; Anna Mae Diehl; Benjamin Alman; Wolfram Goessling; Zhenyu Yue; Xiao-Fan Wang; Terje Johansen; Zhixun Dou
Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming

去抑制核内丙酮酸脱氢酶可诱导治疗性癌细胞重编程

Cell Metabolism
IF30.9
2025-06-110
PRE
Ting Zhao; Lingli He; Lai Ping Wong; Shenglin Mei; Jun Xia; Yanxin Xu; Jonathan G. Van Vranken; Michael Mazzola; Lei Chen; Catherine Rhee; Tiancheng Fang; Tsuyoshi Fukushima; Leanne C. Sayles; Matthew Diaz; J. Alex B. Gibbons; Raul Mostoslavsky; Steven P. Gygi; Zhixun Dou; David B. Sykes; Ruslan I. Sadreyev; E. Alejandro Sweet-Cordero; David T. Scadden
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

p53增强DNA修复，并抑制衰老细胞中的细胞质染色质片段和炎症。

NATURE COMMUNICATIONS
IF15.7
2025-03-050
OA
Miller, Karl N.; Li, Brightany; Pierce-Hoffman, Hannah R.; Patel, Shreeya; Lei, Xue; Rajesh, Adarsh; Teneche, Marcos G.; Havas, Aaron P.; Gandhi, Armin; Macip, Carolina Cano; Lyu, Jun; Victorelli, Stella G.; Woo, Seung-Hwa; Lagnado, Anthony B.; Laporta, Michael A.; Liu, Tianhui; Dasgupta, Nirmalya; Li, Sha; Davis, Andrew; Korotkov, Anatoly; Hultenius, Erik; Gao, Zichen; Altman, Yoav; Porritt, Rebecca A.; Garcia, Guillermina; Mogler, Carolin; Seluanov, Andrei; Gorbunova, Vera; Kaech, Susan M.; Tian, Xiao; Dou, Zhixun; Chen, Chongyi; Passos, Joao F.; Adams, Peter D.
AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

通过抑制硒蛋白生物合成，引起Cgas-Sting激活和铁死亡，从而清除AML干细胞

BLOOD
IF23.1
2024-11-050
PRE
He, Lingli; Zhao, Ting; Leong, Wei Zhong; Sharda, Azeem; Mayerhofer, Christina; Mei, Shenglin; Bonilla, Gracia M.; Menendez-Gonzalez, Juan Bautista; Gustafsson, Karin; Fukushima, Tsuyoshi; Kristiansen, Trine A.; Lee, Ji-Won; Xu, Yanxin; Budnik, Bogdan; Sadreyev, Ruslan; Dou, Zhixun; Sykes, David B.; Scadden, David
Modulating mRNA Translation Fidelity As a Novel Mechanism for AML Chemoresistance

调节mRNA翻译保真度作为一种AML化疗耐药的新机制

BLOOD
IF23.1
2024-11-050
PRE
Mayerhofer, Christina; Li, Dan; Kristiansen, Trine A.; Mayerhofer, Ernst; Sharda, Azeem; He, Lingli; Mazzola, Michael; Schiroli, Giulia; Gustafsson, Karin; Keyes, Sam; Kiem, Anna; Crompton, Eve; Xu, Yanxin; Dou, Zhixun; Vidoudez, Charles; Miller, Peter G.; Van Gastel, Nick; Scadden, David
SenNet recommendations for detecting senescent cells in different tissues

SenNet建议检测不同组织中的衰老细胞

NATURE REVIEWS MOLECULAR CELL BIOLOGY
IF90.2
2024-06-0324
PRE
Suryadevara, Vidyani; Hudgins, Adam D.; Rajesh, Adarsh; Pappalardo, Alberto; Karpova, Alla; Dey, Amit K.; Hertzel, Ann; Agudelo, Anthony; Rocha, Azucena; Soygur, Bikem; Schilling, Birgit; Carver, Chase M.; Aguayo-Mazzucato, Cristina; Baker, Darren J.; Bernlohr, David A.; Jurk, Diana; Mangarova, Dilyana B.; Quardokus, Ellen M.; Enninga, Elizabeth Ann L.; Schmidt, Elizabeth L.; Chen, Feng; Duncan, Francesca E.; Cambuli, Francesco; Kaur, Gagandeep; Kuchel, George A.; Lee, Gung; Daldrup-Link, Heike E.; Martini, Helene; Phatnani, Hemali; Al-Naggar, Iman M.; Rahman, Irfan; Nie, Jia; Passos, Joao F.; Silverstein, Jonathan C.; Campisi, Judith; Wang, Julia; Iwasaki, Kanako; Barbosa, Karina; Metis, Kay; Nernekli, Kerem; Niedernhofer, Laura J.; Ding, Li; Wang, Lichao; Adams, Lisa C.; Ruiyang, Liu; Doolittle, Madison L.; Teneche, Marcos G.; Schafer, Marissa J.; Xu, Ming; Hajipour, Mohammadjavad; Boroumand, Mozhgan; Basisty, Nathan; Sloan, Nicholas; Slavov, Nikolai; Kuksenko, Olena; Robson, Paul; Gomez, Paul T.; Vasilikos, Periklis; Adams, Peter D.; Carapeto, Priscila; Zhu, Quan; Ramasamy, Ramalakshmi; Perez-Lorenzo, Rolando; Fan, Rong; Dong, Runze; Montgomery, Ruth R.; Shaikh, Sadiya; Vickovic, Sanja; Yin, Shanshan; Kang, Shoukai; Suvakov, Sonja; Khosla, Sundeep; Garovic, Vesna D.; Menon, Vilas; Xu, Yanxin; Song, Yizhe; Suh, Yousin; Dou, Zhixun; Neretti, Nicola
Apoptotic stress causes mtDNA release during senescence and drives the SASP

凋亡应激导致衰老过程中mtDNA释放并驱动SASP

Nature
IF48.5
2023-10-110
OAAI
Stella Victorelli; Hanna Salmonowicz; James Chapman; Helene Martini; Maria Grazia Vizioli; Joel S. Riley; Catherine Cloix; Ella Hall-Younger; Jair Machado Espindola-Netto; Diana Jurk; Anthony B. Lagnado; Lilian Sales Gomez; Joshua N. Farr; Dominik Saul; Rebecca Reed; George Kelly; Madeline Eppard; Laura C. Greaves; Zhixun Dou; Nicholas Pirius; Karolina Szczepanowska; Rebecca A. Porritt; Huijie Huang; Timothy Y. Huang; Derek A. Mann; Claudio Akio Masuda; Sundeep Khosla; Haiming Dai; Scott H. Kaufmann; Emmanouil Zacharioudakis; Evripidis Gavathiotis; Nathan K. LeBrasseur; Xue Lei; Alva G. Sainz; Viktor I. Korolchuk; Peter D. Adams; Gerald S. Shadel; Stephen W. G. Tait; João F. Passos
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

NIH SenNet联盟绘制人类整个生命周期中的衰老细胞以了解生理健康

NATURE AGING
IF19.4
2022-12-2049
OA
Lee, Patty J.; Benz, Christopher C.; Blood, Philip; Boerner, Katy; Campisi, Judith; Chen, Feng; Daldrup-Link, Heike; De Jager, Phil; Ding, Li; Duncan, Francesca E.; Eickelberg, Oliver; Fan, Rong; Finkel, Toren; Furman, David; Garovic, Vesna; Gehlenborg, Nils; Glass, Carolyn; Heckenbach, Indra; Joseph, Ziv-Bar; Katiyar, Pragati; Kim, So-Jin; Koenigshoff, Melanie; Kuchel, George A.; Lee, Haesung; Lee, Jun Hee; Ma, Jian; Ma, Qin; Melov, Simon; Metis, Kay; Mora, Ana L.; Musi, Nicolas; Neretti, Nicola; Passos, Joao F.; Rahman, Irfan; Rivera-Mulia, Juan Carlos; Robson, Paul; Rojas, Mauricio; Roy, Ananda L.; Scheibye-Knudsen, Morten; Schilling, Birgit; Shi, Pixu; Silverstein, Jonathan C.; Suryadevara, Vidyani; Xie, Jichun; Wang, Jinhua; Wong, A. Ian; Niedernhofer, Laura J.; Wang, Siyuan (Steven); Anvari, Hannah; Balough, Julia; Benz, Christopher; Bons, Joanna; Brenerman, Boris; Evans, William; Gerencser, Akos; Gregory, Heather; Hansen, Malene; Justice, Jamie; Kapahi, Pankaj; Murad, Natalia; O'Broin, Amy; Pavone, Mary Ellen; Powell, Mark; Scott, Gary; Shanes, Elisheva; Shankaran, Mahalakshmi; Verdin, Eric; Winer, Daniel; Wu, Fei; Adams, Andrew; Blood, Philip D.; Bueckle, Andreas; Cao-Berg, Ivan; Chen, Hao; Davis, Michael; Filus, Shane; Hao, Yuhan; Hartman, Austin; Hasanaj, Euxhen; Helfer, Jesse; Herr, Bruce, II; Bar Joseph, Ziv; Molla, Gesmira; Mou, Gloria; Puerto, Juan; Quardokus, Ellen M.; Ropelewski, Alexander J.; Ruffalo, Matt; Satija, Rahul; Schwenk, Melissa; Scibek, Robin; Shirey, William; Sibilla, Max; Welling, Joel; Yuan, Zhou; Bonneau, Richard; Christiano, Angela; Izar, Benjamin; Menon, Vilas; Owens, David M.; Phatnani, Hemali; Smith, Colin; Suh, Yousin; Teich, Andrew F.; Bekker, Valerie; Chan, Cliburn; Coutavas, Elias; Hartwig, Matthew G.; Ji, Zhicheng; Nixon, Andrew B.; Dou, Zhixun; Rajagopal, Jayaraj; Slavov, Nikolai; Holmes, David, III; Jurk, Diana; Kirkland, James L.; Lagnado, Anthony; Tchkonia, Tamara; Abraham, Kristin; Dibattista, Amanda; Fridell, Yih-Woei; Howcroft, T. Kevin; Jhappan, Chamelli; Montes, Viviana Perez; Prabhudas, Mercy; Resat, Haluk; Taylor, Veronica; Kumar, Manoj; Cigarroa, Francisco; Cohn, Rachel; Cortes, Tiffany M.; Courtois, Elise; Chuang, Jeffrey; Dave, Monica; Domanskyi, Sergii; Enninga, Elizabeth Ann Lieser; Eryilmaz, Giray Naim; Espinoza, Sara E.; Gelfond, Jon; Kirkland, James; Kuo, Chia-Ling; Lehman, Julia S.; Aguayo-Mazzucato, Cristina; Meves, Alexander; Rani, Meenakshi; Sanders, Shane; Thibodeau, Asa; Tullius, Stefan G.; Ucar, Duygu; White, Brian; Wu, Qian; Xu, Ming; Yamaguchi, Seiji; Assarzadegan, Naziheh; Cho, Chun-Seok; Hwang, Irene; Hwang, Yongha; Xi, Jingyue; Adeyi, Oyedele A.; Aliferis, Constantin F.; Bartolomucci, Alessandro; Dong, Xiao; DuFresne-To, Mickayla J.; Ikramuddin, Sayeed; Johnson, Steve G.; Nelson, Andrew C.; Revelo, Xavier S.; Trevilla-Garcia, Claudia; Sedivy, John M.; Thompson, Elizabeth L.; Robbins, Paul D.; Wang, Jinhua; Aird, Katherine M.; Alder, Jonathan K.; Beaulieu, Delphine; Bueno, Marta; Calyeca, Jazmin; Chamucero-Millaris, Julian A.; Chan, Stephen Y.; Chung, Dongjun; Corbett, Anthony; Gorbunova, Vera; Gowdy, Kymberly M.; Gurkar, Aditi; Horowitz, Jeffrey C.; Hu, Qianjiang; Kaur, Gagandeep; Khaliullin, Timur O.; Lafyatis, Robert; Lanna, Serafina; Li, Dongmei; Ma, Anjun; Morris, Alison; Muthumalage, Thivanka M.; Peters, Victor; Pryhuber, Gloria S.; Reader, Brenda F.; Rosas, Lorena; Sembrat, John C.; Shaikh, Sadiya; Shi, Hangchuan; Stacey, Sean D.; St Croix, Claudette; Wang, Cankun; Wang, Qixin; Watts, Andrew; Gu, Liangcai; Lin, Yiing; Rabinovitch, Peter S.; Sweetwyne, Mariya T.; Artyomov, Maxim N.; Ballentine, Samuel J.; Chheda, Milan G.; Davies, Sherri R.; DiPersio, John F.; Fields, Ryan C.; Fitzpatrick, James A. J.; Fulton, Robert S.; Imai, Shin-ichiro; Jain, Sanjay; Ju, Tao; Kushnir, Vladimir M.; Link, Daniel C.; Ben Major, Michael; Oh, Stephen T.; Rapp, Daniel; Rettig, Michael P.; Stewart, Shelia A.; Veis, Deborah J.; Vij, Kiran R.; Wendl, Michael C.; Wyczalkowski, Matthew A.; Craft, Joseph E.; Enninful, Archibald; Farzad, Negin; Gershkovich, Peter; Halene, Stephanie; Kluger, Yuval; VanOudenhove, Jennifer; Xu, Mina; Yang, Junchen; Yang, Mingyu
SIRT1 is downregulated by autophagy in senescence and ageing

SIRT1在衰老和衰老过程中被自噬下调

NATURE CELL BIOLOGY
IF19.1
2020-09-28308
OAAI
Xu, Caiyue; Wang, Lu; Fozouni, Parinaz; Evjen, Gry; Chandra, Vemika; Jiang, Jing; Lu, Congcong; Nicastri, Michael; Bretz, Corey; Winkler, Jeffrey D.; Amaravadi, Ravi; Garcia, Benjamin A.; Adams, Peter D.; Ott, Melanie; Tong, Wei; Johansen, Terje; Dou, Zhixun; Berger, Shelley L.

研究方向

暂未获取到该数据
P
Peter D. Adams
H 指数:78论文数:518被引数:3.3万
S
Shelley L. Berger
H 指数:117论文数:502被引数:5.8万
R
Richard Z. Lin
H 指数:39论文数:117被引数:5,064
Y
Yanxin Xu
H 指数:18论文数:66被引数:1,966
N
Nadia Jaber
H 指数:12论文数:29被引数:7,389
W
Wei‐Xing Zong
H 指数:19论文数:44被引数:1.4万
J
João F. Passos
H 指数:68论文数:201被引数:2.9万
D
David T. Scadden
H 指数:124论文数:667被引数:6.7万
L
Lu Wang
H 指数:30论文数:94被引数:8,262
L
Lingli He
H 指数:22论文数:74被引数:1,522