Holly E. Barker

walter and eliza hall institute of medical research

H指数:21

被引数:5,576

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工作经历

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荣誉奖项

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High-throughput drug screening identifies EGFR/MAPK pathway targeting sensitivities in organoid models of ovarian carcinosarcoma

Journal of Experimental & Clinical Cancer Research

IF12.8

2026-01-060

OAAI

Genomics of uterine malignancies and the potential of precision medicine

子宫恶性肿瘤的基因组学及精准医学的潜力

Therapeutic Advances in Medical Oncology

IF4.2

2025-11-240

Genomics of cervical, vulvar and vaginal cancers and the potential of precision medicine

宫颈癌、外阴癌和阴道癌的基因组学及精准医学的潜力

Therapeutic Advances in Medical Oncology

IF4.2

2025-09-280

Farletuzumab ecteribulin and MORAb-109, folate receptor alpha and mesothelin targeting antibody-drug conjugates, show activity in poor prognosis gynaecological cancer models

Farletuzumab ecteribulin和MORAb-109，靶向叶酸受体α和间皮素的抗体-药物偶联物，在预后不良的妇科癌症模型中显示出活性。

CLINICAL AND TRANSLATIONAL MEDICINE

IF6.8

2025-03-120

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

MOLECULAR CANCER

IF33.9

2024-08-050

OAAI

Nesic, Ksenija; Krais, John J.; Wang, Yifan; Vandenberg, Cassandra J.; Patel, Pooja; Cai, Kathy Q.; Kwan, Tanya; Lieschke, Elizabeth; Ho, Gwo-Yaw; Barker, Holly E.; Bedo, Justin; Casadei, Silvia; Farrell, Andrew; Radke, Marc; Shield-Artin, Kristy; Penington, Jocelyn S.; Geissler, Franziska; Kyran, Elizabeth; Betsch, Robert; Xu, Lijun; Zhang, Fan; Dobrovic, Alexander; Olesen, Inger; Kristeleit, Rebecca; Oza, Amit; McNeish, Iain; Ratnayake, Gayanie; Traficante, Nadia; DeFazio, Anna; Bowtell, David D. L.; Harding, Thomas C.; Lin, Kevin; Swisher, Elizabeth M.; Kondrashova, Olga; Scott, Clare L.; Johnson, Neil; Wakefield, Matthew J.

A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq

GENOMICS

IF3

2024-03-015

OAAI

Brown, Daniel, V; Anttila, Casey J. A.; Ling, Ling; Grave, Patrick; Baldwin, Tracey M.; Munnings, Ryan; Farchione, Anthony J.; Bryant, Vanessa L.; Dunstone, Amelia; Biben, Christine; Taoudi, Samir; Weber, Tom S.; Naik, Shalin H.; Hadla, Anthony; Barker, Holly E.; Vandenberg, Cassandra J.; Dall, Genevieve; Scott, Clare L.; Moore, Zachery; Whittle, James R.; Freytag, Saskia; Best, Sarah A.; Papenfussa, Anthony T.; Olechnowicza, Sam W. Z.; Macrailda, Sarah E.; Wilcox, Stephen; Hickey, Peter F.; Amann-Zalcenstein, Daniela; Bowden, Rory

SF3B1 hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress response

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-010

PRE

Bland, Philip; Saville, Harry; Wai, Patty T.; Curnow, Lucinda; Nieminuszczy, Jadwiga; Ravindran, Nivedita; Barker, Holly E.; Wright, James; Yu, Lu; Mavrommati, Ioanna; Peck, Barrie; Gazinska, Patrycja; Pemberton, Helen N.; Gulati, Aditi; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E.; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S.; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Natrajan, Rachael

The microtubule inhibitor eribulin demonstrates efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models

微管抑制剂eribulin在铂耐药和难治性高级浆液性卵巢癌患者来源的异种移植模型中显示出疗效

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

IF4.2

2023-11-221

OAAI

Improving Patient Counselling in Patients' With PI-RADS 3 Lesions with the Use of PSA Density, A Retrospective Study in a UK District General Hospital

BRITISH JOURNAL OF SURGERY

IF8.7

2023-08-300

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

NATURE GENETICS

IF31.8

2023-07-3118

OAAI

Bland, Philip; Saville, Harry; Wai, Patty T.; Curnow, Lucinda; Muirhead, Gareth; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie Beatrix; Hedayat, Somaieh; Barker, Holly E.; Wright, James; Yu, Lu; Mavrommati, Ioanna; Read, Abigail; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen N.; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E.; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S.; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J.; Natrajan, Rachael

Targeting homologous recombination deficiency in uterine leiomyosarcoma

靶向子宫平滑肌肉瘤的同源重组缺陷

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IF12.8

2023-05-0410

OAAI

Dall, Genevieve; Vandenberg, Cassandra J. J.; Nesic, Ksenija; Ratnayake, Gayanie; Zhu, Wenying; Vissers, Joseph H. A.; Bedo, Justin; Penington, Jocelyn; Wakefield, Matthew J. J.; Kee, Damien; Carmagnac, Amandine; Lim, Ratana; Shield-Artin, Kristy; Milesi, Briony; Lobley, Amanda; Kyran, Elizabeth L. L.; O'Grady, Emily; Tram, Joshua; Zhou, Warren; Nugawela, Devindee; Stewart, Kym Pham; Caldwell, Reece; Papadopoulos, Lia; Ng, Ashley P. P.; Dobrovic, Alexander; Fox, Stephen B. B.; McNally, Orla; Power, Jeremy D. D.; Meniawy, Tarek; Tan, Teng Han; Collins, Ian M. M.; Klein, Oliver; Barnett, Stephen; Olesen, Inger; Hamilton, Anne; Hofmann, Oliver; Grimmond, Sean; Papenfuss, Anthony T. T.; Scott, Clare L. L.; Barker, Holly E. E.

Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition

CANCER RESEARCH

IF16.6

2023-03-010

PRE

Bland, Phil; Saville, Harry; Read, Abigail; Wai, Patty; Muirhead, Gareth; Curnow, Lucinda; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie; Hedayat, Somaieh; Barker, Holly; Wright, James; Yu, Lu; Mavrommati, Ioanna; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher; Natrajan, Rachael

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

CANCER RESEARCH

IF16.6

2022-10-0710

OAAI

Ho, Gwo Yaw; Kyran, Elizabeth L.; Bedo, Justin; Wakefield, Matthew J.; Ennis, Darren P.; Mirza, Hasan B.; Vandenberg, Cassandra J.; Lieschke, Elizabeth; Farrell, Andrew; Hadla, Anthony; Lim, Ratana; Dall, Genevieve; Vince, James E.; Chua, Ngee Kiat; Kondrashova, Olga; Upstill-Goddard, Rosanna; Bailey, Ulla-Maja; Dowson, Suzanne; Roxburgh, Patricia; Glasspool, Rosalind M.; Bryson, Gareth; Biankin, Andrew V.; Cooke, Susanna L.; Ratnayake, Gayanie; McNally, Orla; Traficante, Nadia; DeFazio, Anna; Weroha, S. John; Bowtell, David D.; McNeish, Iain A.; Papenfuss, Anthony T.; Scott, Clare L.; Barker, Holly E.

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

CANCER RESEARCH

IF16.6

2021-02-1510

Peck, Barrie; Bland, Philip; Mavrommati, Ioanna; Muirhead, Gareth; Cottom, Hannah; Wai, Patty T.; Maguire, Sarah L.; Barker, Holly E.; Morrison, Eamonn; Kriplani, Divya; Yu, Lu; Gibson, Amy; Falgari, Giulia; Brennan, Keith; Farnie, Gillian; Buus, Richard; Marlow, Rebecca; Novo, Daniela; Knight, Eleanor; Guppy, Naomi; Kolarevic, Daniela; Susnjar, Snezana; Milijic, Natasa Medic; Naidoo, Kalnisha; Gazinska, Patrycja; Roxanis, Ioannis; Pancholi, Sunil; Martin, Lesley-Ann; Holgersen, Erle M.; Cheang, Maggie C. U.; Noor, Farzana; Postel-Vinay, Sophie; Quinn, Gerard; McDade, Simon; Krasny, Lukas; Huang, Paul; Daley, Frances; Wallberg, Fredrik; Choudhary, Jyoti S.; Haider, Syed; Tutt, Andrew N.; Natrajan, Rachael

Genomics of gynaecological carcinosarcomas and future treatment options

SEMINARS IN CANCER BIOLOGY

IF15.7

2020-04-0111

PREAI

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution (vol 71, pg 1561, 2011)

CANCER RESEARCH

IF16.6

2019-10-013

PRE

LOX-Mediated Collagen Cross-linking Is Responsible for Fibrosis-Enhanced Metastasis (Expression of Concern of Vol 73, Pg 1721, 2013)

CANCER RESEARCH