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R

Robert K. Bradley

Fred Hutchinson Cancer Center
H指数:52
被引数:1.8万

个人简介

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Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing

突变SRSF2相关的红细胞生成障碍是由FYN剪接错误导致的mTORC1信号增强所定义。

Leukemia
IF13.4
2026-02-260
PRE
Jonas S. Jutzi; Edie Crosse; Chulwoo J. Kim; Bob van Gasteren; Charles Laurore; Benjamin Rolles; Frederike Kramer; Anastasia Tishena; Azucena V. Rocha; Mohammed Wazir; Lachelle D. Weeks; Joan How; Maximilian Stahl; Marlise R. Luskin; R. Coleman Lindsley; Olga Pozdnyakova; Sumit Rai; Timothy A. Graubert; Robert K. Bradley; Ann Mullally; Anna E. Marneth
TNFα Apoptotic Signaling By Antigen-Engaged CAR T-Cells Mediates Clearance of Target Antigen-Negative Acute Myeloid Leukemia

TNFα介导的抗原激活CAR T细胞凋亡信号清除靶抗原阴性的急性髓系白血病

BLOOD
IF23.1
2024-11-050
PRE
Kimble, Erik L.; Fiorenza, Salvatore; Hirayama, Alexandre V. Vinaud; Gabel, Austin M.; Gauthier, Jordan; Torkelson, Aiko; Chutnik, Abigail; Di, Henna; Wright, Jocelyn H.; Pender, Barbara; Radtke, Stefan; Walter, Roland B.; Kiem, Hans-Peter; Maloney, David G.; Bradley, Robert K.; Turtle, Cameron J.
GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
MOLECULAR CELL
IF16.6
2024-05-016
OAAI
Benbarche, Salima; Pineda, Jose Mario Bello; Galvis, Laura Baquero; Biswas, Jeetayu; Liu, Bo; Wang, Eric; Zhang, Qian; Hogg, Simon J.; Lyttle, Kadeen; Dahi, Ariana; Lewis, Alexander M.; Saechi, Martina; Rahman, Jahan; Fox, Nina; Ai, Yuxi; Mehta, Sanjoy; Garippa, Ralph; Ortiz-Pacheco, Juliana; Li, Zhuoning; Monetti, Mara; Stanley, Robert F.; Doulatov, Sergei; Bradley, Robert K.; Abdel-Wahab, Omar
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
CANCER RESEARCH
IF16.6
2023-04-041
PRE
Thomas, James D.; Lu, Sydney X.; De Neef, Emma; Sabio, Erich; Rousseau, Benoit; Gigoux, Mathieu; Knorr, David A.; Greenbaum, Benjamin; Elhanati, Yuval; Hogg, Simon J.; Chow, Andrew; Ghosh, Arnab; Xie, Abigail; Zamarin, Dmitriy; Cui, Daniel; Erickson, Caroline; Singer, Michael; Cho, Hana; Wang, Eric; Lu, Bin; Durham, Benjamin H.; Shah, Harshal; Chowell, Diego; Gabel, Austin M.; Shen, Yudao; Liu, Jing; Jin, Jian; Rhodes, Matthew C.; Taylor, Richard E.; Molina, Henrik; Wolchok, Jedd D.; Merghoub, Taha; Diaz, Luis A., Jr.; Abdel-Wahab, Omar; Bradley, Robert K.
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations
ELIFE
IF0
2022-08-3040
OA
Choudhary, Gaurav S.; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A.; Bhagat, Tushar D.; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N.; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa, V; Pillai, Manoj M.; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K.; Martell, Robert E.; Steidl, Ulrich G.; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T.; Verma, Amit
Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells
NATURE BIOTECHNOLOGY
IF41.7
2022-03-0342
OAAI
North, Khrystyna; Benbarche, Salima; Liu, Bo; Pangallo, Joseph; Chen, Sisi; Stahl, Maximilian; Bewersdorf, Jan Philipp; Stanley, Robert F.; Erickson, Caroline; Cho, Hana; Pineda, Jose Mario Bello; Thomas, James D.; Polaski, Jacob T.; Belleville, Andrea E.; Gabel, Austin M.; Udy, Dylan B.; Humbert, Olivier; Kiem, Hans-Peter; Abdel-Wahab, Omar; Bradley, Robert K.

研究方向

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A
Austin M. Gabel
H 指数:8论文数:25被引数:739
O
Omar Abdel‐Wahab
H 指数:116论文数:1,040被引数:5.3万
J
James D. Thomas
H 指数:39论文数:133被引数:4,698
J
Jose Mario Bello Pineda
H 指数:10论文数:36被引数:684
H
Heidi Dvinge
H 指数:22论文数:31被引数:1.1万
A
Andrea E. Belleville
H 指数:6论文数:11被引数:316
E
Edie I. Crosse
H 指数:6论文数:34被引数:246
B
Benjamin H. Durham
H 指数:47论文数:196被引数:8,493
S
Sujatha Jagannathan
H 指数:18论文数:48被引数:1,185
P
Peter S. Nelson
H 指数:113论文数:1,484被引数:6.6万