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J

Jamie I. Fletcher

children's cancer institute
H指数:34
被引数:9,514

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The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity

PLK4抑制剂RP-1664通过双重敏感性机制在神经母细胞瘤临床前模型中显示出显著疗效

Nature Communications
IF15.7
2026-06-130
OAAI
Isabel Soria-Bretones; Matias Casás-Selves; Minu Samanta; David Groff; Jayne Murray; Jamie I. Fletcher; Alvin Farrel; Steven Pastor; Khushbu Patel; Elliot Goodfellow; Li Li; Cathy Caron; Ariya Shiwram; Hyeyeon Kim; Danielle Henry; Nancy Laterreur; Julian Bowlan; Kateryna Krytska; Steven B. Neuhauser; Timothy M. Stearns; Jeffrey A. Schubert; Jinhua Wu; Lea F. Surrey; Daniel Martinez; Crystal Mak; Jennifer Brand; Caitlin Wesley; Klaartje Somers; Alejandro Álvarez-Quilón; Frédéric Vallée; Parham Nejad; Joseph D. Schonhoft; Joanna Li; Artur Veloso; Jordan T. F. Young; Marc L. Hyer; Stephen J. Morris; Yael P. Mossé; C. Gary Marshall; Michelle Haber; Michal Zimmermann; John M. Maris
Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma

在多药联合化疗中加入JNK非依赖性药物可改善复发高风险神经母细胞瘤的治疗反应

SCIENCE ADVANCES
IF12.5
2025-11-280
PRE
Han, Jeremy Z. R.; Phimmachanh, Monica; Hastings, Jordan F.; Leong, King Ho; Ng, Boaz H.; Ni, Jenny; Fontaine-Titley, Angela; Cadell, Antonia L.; O'Donnell, Yolande Ei; Clearwater, Misaki; Kamili, Alvin; Haber, Michelle; Norris, Murray; Timpson, Paul; Trahair, Toby N.; Fletcher, Jamie I.; Fey, Dirk; Kolch, Walter; Latham, Sharissa L.; Croucher, David R.
Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma

第二代AURKA靶向PROTACs：神经母细胞瘤体内降解的结构优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-11-010
PRE
Krols, Simon; Rishfi, Muhammad; Martens, Fien; Van Hauwermeiren, Anouk; Sanders, Ellen; De Sutter, Pieter-Jan; Vermeulen, An; De Wever, Kaat; Bekaert, Sarah-Lee; Dolman, M. Emmy M.; Tax, Gabor; Kamili, Alvin; Fletcher, Jamie I.; Depestel, Lisa; De Wilde, Bram; Durinck, Kaat; Van Calenbergh, Serge
P-glycoprotein as a chemotherapy resistance mechanism and biomarker of poor response in high-risk neuroblastoma
EJC Paediatric Oncology
IF0
2025-11-010
OA
Atkinson, Caroline; Kamili, Alvin; Tactacan, Carole M.; Jayatilleke, Nisitha; Rosser, Sebastian P. A.; Saletta, Federica; Gana, Christine C.; Graber, Philipp; Wanninayaka, Amanda; Ignacio, Rosa Mistica C.; Kavallaris, Maria; Gifford, Andrew J.; Lock, Richard B.; Norris, Murray D.; Haber, Michelle; Mayoh, Chelsea; Nath, Christa E.; Trahair, Toby N.; Fletcher, Jamie I.
High-throughput 3D engineered paediatric tumour models for precision medicine

高通量3D工程化儿科肿瘤模型用于精准医学

Molecular Systems Biology
IF7.7
2025-10-010
OAAI
MoonSun Jung; Valentina Poltavets; Joanna N Skhinas; Gabor Tax; Alvin Kamili; Jinhan Xie; Sarah Ghamrawi; Philipp Graber; Jie Mao; Marie Wong-Erasmus; Louise Cui; Kathleen Kimpton; Pooja Venkat; Chelsea Mayoh; Angela Lin; Emmy D G Fleuren; Ashleigh M Fordham; Zara Barger; John Grady; David M Thomas; Eric Y Du; Nicole S Graf; Mark J Cowley; Andrew J Gifford; Jamie I Fletcher; Loretta M S Lau; M Emmy M Dolman; J Justin Gooding; Maria Kavallaris
The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis

转录共阻遏物Runx1t1对于MYCN驱动的神经母细胞瘤肿瘤发生至关重要

NATURE COMMUNICATIONS
IF15.7
2024-07-111
OAAI
Murray, Jayne E.; Valli, Emanuele; Milazzo, Giorgio; Mayoh, Chelsea; Gifford, Andrew J.; Fletcher, Jamie I.; Xue, Chengyuan; Jayatilleke, Nisitha; Salehzadeh, Firoozeh; Gamble, Laura D.; Rouaen, Jourdin R. C.; Carter, Daniel R.; Forgham, Helen; Sekyere, Eric O.; Keating, Joanna; Eden, Georgina; Allan, Sophie; Alfred, Stephanie; Kusuma, Frances K.; Clark, Ashleigh; Webber, Hannah; Russell, Amanda J.; de Weck, Antoine; Kile, Benjamin T.; Santulli, Martina; De Rosa, Piergiuseppe; Fleuren, Emmy D. G.; Gao, Weiman; Wilkinson-White, Lorna; Low, Jason K. K.; Mackay, Joel P.; Marshall, Glenn M.; Hilton, Douglas J.; Giorgi, Federico M.; Koster, Jan; Perini, Giovanni; Haber, Michelle; Norris, Murray D.
Addition of AMXT1501 (polyamine uptake inhibitor) plus DFMO (polyamine synthesis inhibitor) to standard-of-care chemotherapy/anti-GD2 antibody in the TH-MYCN mouse neuroblastoma model, enhances efficacy compared to addition of DFMO alone
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Murray, Jayne; Pandher, Ruby; Xiao, Lin; Somers, Klaartje; Brand, Jennifer; Mosmann, Erin; Alfred, Stephanie; Kusuma, Frances; Keams, Adam; Park, Julie R.; Marshall, Lynley V.; Gorrini, Chiara; Chesler, Louis; Hogarty, Michael D.; Pearson, Andrew D. J.; Burns, Mark; Fletcher, Jamie I.; Ziegler, David; Norris, Murray D.; Haber, Michelle
High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

原发性肿瘤细胞的高通量药物筛选确定治疗高危癌症儿童的治疗策略

CANCER RESEARCH
IF16.6
2023-07-3114
OAAI
Mayoh, Chelsea; Mao, Jie; Xie, Jinhan; Tax, Gabor; Chow, Shu-Oi; Cadiz, Roxanne; Pazaky, Karina; Barahona, Paulette; Ajuyah, Pamela; Trebilcock, Peter; Malquori, Angela; Gunther, Kate; Avila, Anica; Yun, Doo Young; Alfred, Stephanie; Gopalakrishnan, Anjana; Kamili, Alvin; Wong, Marie; Cowley, Mark J.; Jessop, Sophie; Lau, Loretta M. S.; Trahair, Toby N.; Ziegler, David S.; Fletcher, Jamie I.; Gifford, Andrew J.; Tsoli, Maria; Marshall, Glenn M.; Haber, Michelle; Tyrrell, Vanessa; Failes, Timothy W.; Arndt, Greg M.; Lock, Richard B.; Ekert, Paul G.; Dolman, M. Emmy M.
Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
SCIENCE ADVANCES
IF12.5
2023-03-038
OAAI
Hastings, Jordan F.; Latham, Sharissa L.; Kamili, Alvin; Wheatley, Madeleine S.; Han, Jeremy Z. R.; Wong-Erasmus, Marie; Phimmachanh, Monica; Nobis, Max; Pantarelli, Chiara; Cadell, Antonia L.; O'Donnell, Yolande E. I.; Leong, King Ho; Lynn, Sophie; Geng, Fan-Suo; Cui, Lujing; Yan, Sabrina; Achinger-Kawecka, Joanna; Stirzaker, Clare; Norris, Murray D.; Haber, Michelle; Trahair, Toby N.; Speleman, Frank; De Preter, Katleen; Cowley, Mark J.; Bogdanovic, Ozren; Timpson, Paul; Cox, Thomas R.; Kolch, Walter; Fletcher, Jamie I.; Fey, Dirk; Croucher, David R.
Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma
INTERNATIONAL JOURNAL OF CANCER
IF4.7
2022-11-1710
OA
Seneviratne, Janith A.; Carter, Daniel R.; Mittra, Rituparna; Gifford, Andrew; Kim, Patrick Y.; Luo, Jie-Si; Mayoh, Chelsea; Salib, Alice; Rahmanto, Aldwin S.; Murray, Jayne; Cheng, Ngan C.; Nagy, Zsuzsanna; Wang, Qian; Kleynhans, Ane; Tan, Owen; Sutton, Selina K.; Xue, Chengyuan; Chung, Sylvia A.; Zhang, Yizhuo; Sun, Chengtao; Zhang, Li; Haber, Michelle; Norris, Murray D.; Fletcher, Jamie I.; Liu, Tao; Dilda, Pierre J.; Hogg, Philip J.; Cheung, Belamy B.; Marshall, Glenn M.
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer

肿瘤细胞的体外和体内药物筛选确定高危儿童癌症的新疗法

EMBO MOLECULAR MEDICINE
IF8.3
2021-12-2019
OAAI
Lau, Loretta M. S.; Mayoh, Chelsea; Xie, Jinhan; Barahona, Paulette; MacKenzie, Karen L.; Wong, Marie; Kamili, Alvin; Tsoli, Maria; Failes, Tim W.; Kumar, Amit; Mould, Emily V. A.; Gifford, Andrew; Chow, Shu-Oi; Pinese, Mark; Fletcher, Jamie, I; Arndt, Greg M.; Khuong-Quang, Dong-Anh; Wadham, Carol; Eden, Georgina; Trebilcock, Peter; Joshi, Swapna; Alfred, Stephanie; Gopalakrishnan, Anjana; Khan, Aaminah; Wade, Dylan Grebert; Strong, Patrick A.; Manouvrier, Elodie; Morgan, Lisa T.; Cadiz, Roxanne; Ung, Caitlin; Thomas, David M.; Tucker, Katherine M.; Warby, Meera; McCowage, Geoffrey B.; Dalla-Pozza, Luciano; Byrne, Jennifer A.; Saletta, Federica; Fellowes, Andrew; Fox, Stephen B.; Norris, Murray D.; Tyrrell, Vanessa; Trahair, Toby N.; Lock, Richard B.; Cowley, Mark J.; Ekert, Paul G.; Haber, Michelle; Ziegler, David S.; Marshall, Glenn M.

研究方向

暂未获取到该数据
M
Michelle Haber
H 指数:65论文数:666被引数:1.6万
M
Murray D. Norris
H 指数:61论文数:515被引数:1.3万
A
Alvin Kamili
H 指数:22论文数:132被引数:1,780
G
Glenn M. Marshall
H 指数:62论文数:528被引数:1.1万
T
Toby N. Trahair
H 指数:40论文数:270被引数:5,097
A
Andrew J. Gifford
H 指数:32论文数:198被引数:6,470
J
Jayne Murray
H 指数:20论文数:168被引数:2,110
C
Chelsea Mayoh
H 指数:33论文数:324被引数:3,976
C
Claudia L. Flemming
H 指数:20论文数:77被引数:1,956
M
Michelle J. Henderson
H 指数:31论文数:123被引数:4,357