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Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary 全基因组测序提高了未知原发灶癌症的组织来源诊断和治疗选择。 Rebello, Richard J.; Posner, Atara; Dong, Ruining; Prall, Owen W. J.; Sivakumaran, Tharani; Mitchell, Camilla B.; Flynn, Aidan; Caneborg, Alex; Mitchell, Catherine; Kanwal, Sehrish; Fedele, Clare; Webb, Samantha; Fisher, Krista; Wong, Hui-Li; Balachander, Shiva; Zhu, Wenying; Nicolson, Shannon; Dimitriadis, Voula; Wilcken, Nicholas; Defazio, Anna; Gao, Bo; Singh, Madhu; Collins, Ian M.; Steer, Christopher; Warren, Mark; Karanth, Narayan; Xu, Huiling; Fellowes, Andrew; Hicks, Rodney J.; Stewart, Kym Pham; Shale, Charles; Priestley, Peter; Dawson, Sarah-Jane; Vissers, Joseph H. A.; Fox, Stephen B.; Schofield, Penelope; Bowtell, David; Hofmann, Oliver; Grimmond, Sean M.; Mileshkin, Linda; Tothill, Richard W. 分享 收藏
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PALVEN: A phase Ib study of palbociclib, letrozole and venetoclax in ER and BCL2-positive metastatic breast cancer PALVEN：一项关于palbociclib、letrozole和venetoclax在ER和BCL2阳性转移性乳腺癌中的 Ib 期研究 Muttiah, C.; Martin, F.; Christie, M.; Dawson, S-J.; Desai, J.; Lal, L.; Moodie, K.; Murugasu, A.; Phan, P.; Rosenthal, M.; Travers, A.; Visvader, J.; Whittle, J. R.; Lindeman, G. 分享 收藏
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A Phase II trial of alternating osimertinib and gefitinib therapy in advanced EGFR-T790M positive non-small cell lung cancer: OSCILLATE 奥希替尼和吉非替尼交替治疗晚期EGFR-T790M阳性非小细胞肺癌的II期试验: 振荡 Tan, Lavinia; Brown, Chris; Mersiades, Antony; Lee, Chee Khoon; John, Thomas; Kao, Steven; Newnham, Genni; O'Byrne, Kenneth; Parakh, Sagun; Bray, Victoria; Jasas, Kevin; Yip, Sonia; Wong, Stephen Q.; Ftouni, Sarah; Guinto, Jerick; Chandrashekar, Sushma; Clarke, Stephen; Pavlakis, Nick; Stockler, Martin R.; Dawson, Sarah-Jane; Solomon, Benjamin J. 分享 收藏
The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection van der Pol, Ymke; Moldovan, Norbert; Ramaker, Jip; Bootsma, Sanne; Lenos, Kristiaan J.; Vermeulen, Louis; Sandhu, Shahneen; Bahce, Idris; Pegtel, D. Michiel; Wong, Stephen Q.; Dawson, Sarah-Jane; Chandrananda, Dineika; Mouliere, Florent 分享 收藏
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer 发现一种高效，选择性，口服生物利用度的KAT6A/B组蛋白乙酰转移酶抑制剂，对KAT6A-high ER乳腺癌有效 Sharma, Shikhar; Chung, Chi-Yeh; Uryu, Sean; Petrovic, Jelena; Cao, Joan; Rickard, Amanda; Nady, Nataliya; Greasley, Samantha; Johnson, Eric; Brodsky, Oleg; Khan, Showkhin; Wang, Hui; Wang, Zhenxiong; Zhang, Yong; Tsaparikos, Konstantinos; Chen, Lei; Mazurek, Anthony; Lapek, John; Kung, Pei-Pei; Sutton, Scott; Richardson, Paul F.; Greenwald, Eric C.; Yamazaki, Shinji; Jones, Rhys; Maegley, Karen A.; Bingham, Patrick; Lam, Hieu; Stupple, Alexandra E.; Kamal, Aileen; Chueh, Anderly; Cuzzupe, Anthony; Morrow, Benjamin J.; Ren, Bin; Carrasco-Pozo, Catalina; Tan, Chin Wee; Bhuva, Dharmesh D.; Allan, Elizabeth; Surgenor, Elliot; Vaillant, Francois; Pehlivanoglu, Havva; Falk, Hendrik; Whittle, James R.; Newman, Janet; Cursons, Joseph; Doherty, Judy P.; White, Karen L.; Macpherson, Laura; Devlin, Mark; Dennis, Matthew L.; Hattarki, Meghan K.; De Silva, Melanie; Camerino, Michelle A.; Butler, Miriam S.; Dolezal, Olan; Pilling, Patricia; Foitzik, Richard; Stupple, Paul A.; Lagiakos, H. Rachel; Walker, Scott R.; Hediyeh-Zadeh, Soroor; Nuttall, Stewart; Spall, Sukhdeep; Charman, Susan A.; Connor, Theresa; Peat, Thomas S.; Avery, Vicky M.; Bozikis, Ylva E.; Yang, Yuqing; Zhang, Ming; Monahan, Brendon J.; Voss, Anne K.; Street, Ian P.; Dawson, Sarah-Jane; Dawson, Mark A.; Lindeman, Geoffrey J.; Davis, Melissa J.; Visvader, Jane E.; Paul, Thomas A. 分享 收藏
Trial redesign for the phase II/III DETECTION trial: circulating tumour DNA-guided therapy for stage IIB/C melanoma after surgical resection Muinonen-Martin, Andy; Lee, Rebecca; Rothwell, Dominic; Jackson, Richard; Smith, Nigel; Wong, Stephen; Kelso, Noel; Hewitt, Chelsee; Mitchell, Jackie; Jones, Kate; Turajlic, Samra; Corrie, Pippa; Marais, Richard; Middleton, Mark; Dawson, Sarah-Jane; Sandhu, Shahneen; Dive, Caroline; Lorrigan, Paul 分享 收藏
SPEN is a biomarker for CDK4/6 inhibitor resistance in patients with metastatic hormone receptor positive (HR+)/HER2-breast cancer Van Geelen, Courtney T.; Teo, Zhi Ling; Savas, Peter; Luen, Stephen J.; Clarke, Kylie A.; Sant, Sneha; Cowley, Karla J.; Caramia, Franco; Simpson, Kaylene J.; Andre, Fabrice; Dawson, Sarah-Jane; Pearson, Richard; Loi, Sherene 分享 收藏
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes Sparbier, Christina E.; Gillespie, Andrea; Gomez, Juliana; Kumari, Nishi; Motazedian, Ali; Chan, Kah Lok; Bell, Charles C.; Gilan, Omer; Chan, Yih-Chih; Popp, Sarah; Gough, Daniel J.; Eckersley-Maslin, Melanie A.; Dawson, Sarah-Jane; Lehner, Paul J.; Sutherland, Kate D.; Ernst, Patricia; McGeehan, Gerard M.; Lam, Enid Y. N.; Burr, Marian L.; Dawson, Mark A. 分享 收藏
Clinical validation and implementation of droplet digital PCR for the detection of BRAF mutations from cell-free DNA 液滴数字PCR检测游离DNA中BRAF突变的临床验证和实施 Arnolda, Rainer; Howlett, Kerry; Chan, Timmy; Raleigh, Jeanette; Hatzimihalis, Athena; Bell, Anthony; Fellowes, Andrew; Sandhu, Shahneen; Mcarthur, Grant A.; Fox, Stephen B.; Dawson, Sarah-jane; Hewitt, Chelsee; Jones, Kate; Wong, Stephen Q. 分享 收藏
Circulating tumor DNA (ctDNA) dynamics of response and resistance in BRAF V600E mutant (mt) metastatic colorectal (mCRC) and other cancers: Data from EVICT (erlotinib and vemurafenib in combination trial) Tan, L.; Tran, B.; Tie, J.; Link, E.; Wong, S. Q.; Chandrashekar, S.; Guinto, J.; Markman, B.; Ananda, S.; Tebbutt, N. C.; Michael, M.; Solomon, B. J.; McArthur, G.; Gibbs, P.; Dawson, S-J.; Desai, J. 分享 收藏
Clinical implications of prospective genomic profiling of metastatic breast cancer patients (vol 22, 91, 2020) van Geelen, Courtney T.; Savas, Peter; Teo, Zhi Ling; Luen, Stephen J.; Weng, Chen-Fang; Ko, Yi-An; Kuykhoven, Keilly S.; Caramia, Franco; Salgado, Roberto; Francis, Prudence A.; Dawson, Sarah-Jane; Fox, Stephen B.; Fellowes, Andrew; Loi, Sherene 分享 收藏
Alpelisib Monotherapy for PI3K-Altered Pretreated Advanced Breast Cancer A Phase II Study Savas, Peter; Lo, Louisa L.; Luen, Stephen J.; Blackley, Elizabeth F.; Callahan, Jason; Moodie, Kate; van Geelen, Courtney T.; Ko, Yi-An; Weng, Chen -Fang; Wein, Lironne; Silva, Maria Joao; Bujak, Andjelija Zivanovic; Yeung, Miriam M.; Ftouni, Sarah; Hicks, Rodney J.; Francis, Prudence A.; Lee, Chee Khoon; Dawson, Sarah -Jane; Loi, Sherene 分享 收藏
Randomized trial of neoadjuvant chemotherapy with or without concurrent aromatase inhibitor therapy to downstage ER plus ve breast cancer: Breast Cancer Trials Group ANZ 1401 ELIMINATE trial Murray, N.; Francis, P.; Zdenkowski, N.; Wilcken, N.; Boyle, F.; Gebski, V.; Tiley, S. M.; Gilham, L.; Dawson, S-J.; Loi, S.; Redfern, A. D.; Lombard, J.; Spillane, A.; Shadbolt, C.; Badger, H. 分享 收藏
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death Garciaz, Sylvain; Guirguis, Andrew A.; Muller, Sebastian; Brown, Fiona C.; Chan, Yih-Chih; Motazediani, Ali; Rowe, Caitlin L.; Kuzich, James A.; Chan, Kah Lok; Tran, Kevin; Smith, Lorey; MacPherson, Laura; Liddicoat, Brian; Lam, Enid Y. N.; Caneque, Tatiana; Burr, Marian L.; Litalien, Veronique; Pomilio, Giovanna; Poplineau, Mathilde; Duprez, Estelle; Dawson, Sarah-Jane; Ramm, Georg; Cox, Andrew G.; Brown, Kristin K.; Huang, David C. S.; Wei, Andrew H.; McArthur, Kate; Rodriguez, Raphael; Dawson, Mark A. 分享 收藏
Alpelisib monotherapy for PI3K-altered, pre-treated advanced breast cancer: A phase II study Savas, Peter; Lo, Louisa Lisa; Luen, Stephen James; Blackley, Elizabeth Fay; van Geelen, Courtney Templeton; Ko, Yi-An; Moodie, Kate; Callahan, Jason William; Weng, Chen-Fang; Bujak, Andjelija Zivanovic; Yeung, Miriam Manning; Ftouni, Sarah; Francis, Prudence Anne; Dawson, Sarah-Jane; Loi, Sherene 分享 收藏
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