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E

Enid Y.N. Lam

University of Melbourne
H指数:27
被引数:5,715

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SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Nature Genetics
IF29
2026-07-210
PRE
Brian J. Liddicoat; Jesse J. Balic; Wendy Jia; Andrea Gillespie; Andrew B. Das; Laura Scolamiero; Naiara G. Bediaga; Yih-Chih Chan; Christa van der Maarel; Andrew A. Guirguis; Kelsy Prest; Oliver J. Sinclair; Laure Talarmain; Cassandra Litchfield; Enid Y. N. Lam; Sebastian Hollizeck; John R. Horton; Benjamin Kroeger; Tao Wang; Francesca Zappacosta; Roland S. Annan; Rab K. Prinjha; Melissa B. Pappalardi; Michael T. McCabe; Ching-Seng Ang; Matthew S. Graus; Mathias Francois; Kieran F. Harvey; Sarah-Jane Dawson; Xiaodong Cheng; Mark A. Dawson
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors

抗原反应性定义了肿瘤中的组织驻留记忆T细胞和耗竭T细胞。

Nature Immunology
IF27.6
2025-12-290
OAAI
Thomas N. Burn; Jan Schröder; Luke C. Gandolfo; Maleika Osman; Elanor N. Wainwright; Enid Y. N. Lam; Keely M. McDonald; Rachel B. Evans; Shihan Li; Daniel Rawlinson; Lachlan Dryburgh; Ali Zaid; Zoltan Maliga; Dominick Schienstock; Philippa Meiser; Hyun Jae Lee; Hongjin Lai; Marcela L. Moreira; Pirooz Zareie; Louis H-Y. Lee; Lutfi Huq; Susan N. Christo; Justine J. W. Seow; Keith A. Ching; Stéphane M. Guillaume; Kathy Knezevic; Simone L. Park; Maximilien Evrard; Jason Waithman; Thomas Gebhardt; Scott N. Mueller; Georgina E. Riddiough; Marcos V. Perini; Simon C. H. Tsao; Terence P. Speed; Peter K. Sorger; Sherene Loi; Francis R. Carbone; Stephanie Gras; Timothy S. Fisher; Bas J. Baaten; Mark A. Dawson; Laura K. Mackay
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription

mRNA外运因子作为适应性反应，将新生转录本储存在核斑片中，以应对转录的暂时性全局抑制

MOLECULAR CELL
IF16.6
2025-01-011
PRE
Williams, Tobias D.; Michalak, Ewa M.; Carey, Kirstyn. T.; Lam, Enid Y. N.; Griesbach, Esther; Chan, Yih-Chih; Papasaikas, Panagiotis; Ngo, Linh; Macpherson, Laura; Gilan, Omer; Rucinski, Amber; Rutkowska-Klute, Anna; Zinn, Nico; Grandi, Paola; Bantscheff, Marcus; Tan, Vicky W. T.; Prinjha, Rab K.; Dawson, Sarah-Jane; Chao, Jeffrey A.; Wickramsinghe, Vihandha O.; Dawson, Mark A.
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity (vol 42, 113014, 2023)
CELL REPORTS
IF6.9
2024-02-010
OA
House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma V.; Tong, Junming; Nguyen, Datminh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A.
Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

抑制METTL3导致细胞内在的干扰素反应，从而增强抗肿瘤免疫力

CANCER DISCOVERY
IF33.3
2023-08-0729
PRE
Guirguis, Andrew A.; Ofir-Rosenfeld, Yaara; Knezevic, Kathy; Blackaby, Wesley; Hardick, David; Chan, Yih-Chih; Motazedian, Ali; Gillespie, Andrea; Vassiliadis, Dane; Lam, Enid Y. N.; Tran, Kevin; Andrews, Byron; Harbour, Michael E.; Vasiliauskaite, Lina; Saunders, Claire J.; Tsagkogeorga, Georgia; Azevedo, Aleksandra; Obacz, Joanna; Pilka, Ewa S.; Carkill, Marie; Macpherson, Laura; Wainwright, Elanor N.; Liddicoat, Brian; Blyth, Benjamin J.; Albertella, Mark R.; Rausch, Oliver; Dawson, Mark A.
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

CRISPR-Cas9筛选确定了限制CXCL9表达和抗肿瘤免疫的IRF1-SOCS1-mediated负反馈回路

CELL REPORTS
IF6.9
2023-08-016
OA
House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma, V; Tong, Junming; Nguyen, DatMinh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A.
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
NATURE CELL BIOLOGY
IF19.1
2023-01-1215
OAAI
Sparbier, Christina E.; Gillespie, Andrea; Gomez, Juliana; Kumari, Nishi; Motazedian, Ali; Chan, Kah Lok; Bell, Charles C.; Gilan, Omer; Chan, Yih-Chih; Popp, Sarah; Gough, Daniel J.; Eckersley-Maslin, Melanie A.; Dawson, Sarah-Jane; Lehner, Paul J.; Sutherland, Kate D.; Ernst, Patricia; McGeehan, Gerard M.; Lam, Enid Y. N.; Burr, Marian L.; Dawson, Mark A.
Non-genetic determinants of malignant clonal fitness at single-cell resolution

单细胞分辨率下恶性克隆适合度的非遗传决定因素

Nature
IF48.5
2021-12-080
PRE
Katie A. Fennell; Dane Vassiliadis; Enid Y. N. Lam; Luciano G. Martelotto; Jesse J. Balic; Sebastian Hollizeck; Tom S. Weber; Timothy Semple; Qing Wang; Denise C. Miles; Laura MacPherson; Yih-Chih Chan; Andrew A. Guirguis; Lev M. Kats; Emily S. Wong; Sarah-Jane Dawson; Shalin H. Naik; Mark A. Dawson
BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation
SCIENCE ADVANCES
IF12.5
2021-05-2821
OAAI
Vershinin, Zlata; Feldman, Michal; Werner, Thilo; Wei, Lital Estrella; Kublanovsky, Margarita; Abaev-Schneiderman, Elina; Sklarz, Menachem; Lam, Enid Y. N.; Alasad, Khawla; Picaud, Sarah; Rotblat, Barak; McAdam, Ruth A.; Chalifa-Caspi, Vered; Bantscheff, Marcus; Chapman, Trevor; Lewis, Huw D.; Filippakopoulos, Panagis; Dawson, Mark A.; Grandi, Paola; Prinjha, Rab K.; Levy, Dan
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
NATURE CANCER
IF28.5
2020-11-0958
OAAI
Watt, April C.; Cejas, Paloma; DeCristo, Molly J.; Metzger-Filho, Otto; Lam, Enid Y. N.; Qiu, Xintao; BrinJones, Haley; Kesten, Nikolas; Coulson, Rhiannon; Font-Tello, Alba; Lim, Klothilda; Vadhi, Raga; Daniels, Veerle W.; Montero, Joan; Taing, Len; Meyer, Clifford A.; Gilan, Omer; Bell, Charles C.; Korthauer, Keegan D.; Giambartolomei, Claudia; Pasaniuc, Bogdan; Seo, Ji-Heui; Freedman, Matthew L.; Ma, Cynthia; Ellis, Matthew J.; Krop, Ian; Winer, Eric; Letai, Anthony; Brown, Myles; Dawson, Mark A.; Long, Henry W.; Zhao, Jean J.; Goel, Shom
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Science
IF45.8
2020-01-010
OAAI
Omer Gilan; Inmaculada Rioja; Kathy Knezevic; Matthew J. Bell; Miriam M. Yeung; Nicola Harker; Enid Y.N. Lam; Chun‐wa Chung; Paul Bamborough; M. Petretich; Marjeta Urh; Stephen J. Atkinson; Anna K. Bassil; Emma J. Roberts; Dane Vassiliadis; Marian L. Burr; Alex G. S. Preston; Christopher R. Wellaway; Thilo Werner; James R. Gray; Anne‐Marie Michon; Thomas Gobbetti; Vinod D. Kumar; Peter E. Soden; Andrea C. Haynes; Johanna Vappiani; David F. Tough; Simon Taylor; Sarah‐Jane Dawson; Marcus Bantscheff; Matthew J. Lindon; Gerard Drewes; Emmanuel H. Demont; Danette L. Daniels; Paola Grandi; Rab K. Prinjha; Mark A. Dawson
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
NATURE COMMUNICATIONS
IF15.7
2019-06-20124
OAAI
Bell, Charles C.; Fenne, Katie A.; Chan, Yih-Chih; Rambow, Florian; Yeung, Miriam M.; Vassiliadis, Dane; Lara, Luis; Yeh, Paul; Martelotto, Luciano G.; Rogiers, Aljosja; Kremer, Brandon E.; Barbash, Olena; Mohammad, Helai P.; Johanson, Timothy M.; Burr, Marian L.; Dhar, Arindam; Karpinich, Natalie; Tian, Luyi; Tyler, Dean S.; MacPherson, Laura; Shi, Junwei; Pinnawala, Nathan; Fong, Chun Yew; Papenfuss, Anthony T.; Grimmond, Sean M.; Dawson, Sarah-Jane; Allan, Rhys S.; Kruger, Ryan G.; Vakoc, Christopher R.; Goode, David L.; Naik, Shalin H.; Gilan, Omer; Lam, Enid Y. N.; Marine, Jean-Christophe; Prinjha, Rab K.; Dawson, Mark A.
Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
NATURE MEDICINE
IF50
2018-11-19149
PREAI
Agarwal, Rishu; Chan, Yih-Chih; Tam, Constantine S.; Hunter, Tane; Vassiliadis, Dane; Teh, Charis E.; Thijssen, Rachel; Yeh, Paul; Wong, Stephen Q.; Ftouni, Sarah; Lam, Enid Y. N.; Anderson, Mary Ann; Pott, Christiane; Gilan, Omer; Bell, Charles C.; Knezevic, Kathy; Blombery, Piers; Rayeroux, Kathleen; Zordan, Adrian; Li, Jason; Huang, David C. S.; Wall, Meaghan; Seymour, John F.; Gray, Daniel H. D.; Roberts, Andrew W.; Dawson, Mark A.; Dawson, Sarah-Jane
Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
NATURE COMMUNICATIONS
IF15.7
2017-03-1780
OAAI
Yeh, Paul; Hunter, Tane; Sinha, Devbarna; Ftouni, Sarah; Wallach, Elise; Jiang, Damian; Chan, Yih-Chih; Wong, Stephen Q.; Silva, Maria Joao; Vedururu, Ravikiran; Doig, Kenneth; Lam, Enid; Arnau, Gisela Mir; Semple, Timothy; Wall, Meaghan; Zivanovic, Andjelija; Agarwal, Rishu; Petrone, Pasquale; Jones, Kate; Westerman, David; Blombery, Piers; Seymour, John F.; Papenfuss, Anthony T.; Dawson, Mark A.; Tam, Constantine S.; Dawson, Sarah-Jane
Functional interdependence of BRD4 and DOT1L in MLL leukemia
NATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
2016-06-1391
OA
Gilan, Omer; Lam, Enid Y. N.; Becher, Isabelle; Lugo, Dave; Cannizzaro, Ester; Joberty, Gerard; Ward, Aoife; Wiese, Meike; Fong, Chun Yew; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; MacPherson, Laura; Weng, Chen-Fang; Chan, Yih-Chih; Ghisi, Margherita; Smil, David; Carpenter, Christopher; Brown, Peter; Garton, Neil; Blewitt, Marnie E.; Bannister, Andrew J.; Kouzarides, Tony; Huntly, Brian J. P.; Johnstone, Ricky W.; Drewes, Gerard; Dawson, Sarah-Jane; Arrowsmith, Cheryl H.; Grandi, Paola; Prinjha, Rab K.; Dawson, Mark A.

研究方向

暂未获取到该数据
M
Mark A. Dawson
H 指数:55论文数:386被引数:1.8万
O
Omer Gilan
H 指数:21论文数:42被引数:4,844
Y
Yih-Chih Chan
H 指数:17论文数:142被引数:2,993
S
Sarah‐Jane Dawson
H 指数:57论文数:254被引数:2.3万
R
Rab K. Prinjha
H 指数:64论文数:229被引数:1.9万
C
Charles C. Bell
H 指数:18论文数:35被引数:2,988
D
Dane Vassiliadis
H 指数:12论文数:142被引数:1,899
M
Marian L. Burr
H 指数:19论文数:106被引数:3,716
K
Kathy Knezevic
H 指数:26论文数:164被引数:3,812
P
Paola Grandi
H 指数:40论文数:139被引数:1.5万