未登录.png)
分享.png)
收藏分享 收藏 分享 收藏 High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation对100 000个小分子进行高通量筛选，在C9ORF72 ALS神经元中鉴定出可促使G4C2重复RNA进入核输出并引发与重复相关的非规范翻译的剪接体调节剂。
Luteijn, Maartje J.; Bhaskar, Varun; Trojer, Dominic; Schuerz, Melanie; Mahboubi, Hicham; Handl, Cornelia; Pizzato, Nicolas; Pfeifer, Martin; Dafinca, Ruxandra; Voshol, Hans; Giorgetti, Elisa; Manneville, Carole; Garnier, Isabelle P. M.; Mueller, Matthias; Zeng, Fanning; Buntin, Kathrin; Markwalder, Roger; Schroeder, Harald; Weiler, Jan; Khar, Dora; Schuhmann, Tim; Groot-Kormelink, Paul J.; Keller, Caroline Gubser; Farmer, Pierre; MacKay, Angela; Beibel, Martin; Roma, Guglielmo; D'Ario, Giovanni; Merkl, Claudia; Schebesta, Michael; Hild, Marc; Elwood, Fiona; Vahsen, Bjoern F.; Ripin, Nina; Clery, Antoine; Allain, Frederic; Labow, Mark; Gabriel, Daniela; Chao, Jeffrey A.; Talbot, Kevin; Nash, Mark; Hunziker, Juerg; Meisner-Kober, Nicole C. 分享 收藏 Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditionsKarjalainen, Anzhelika; Witalisz-Siepracka, Agnieszka; Prchal-Murphy, Michaela; Martin, David; Sternberg, Felix; Krunic, Milica; Dolezal, Marlies; Fortelny, Nikolaus; Farlik, Matthias; Macho-Maschler, Sabine; Lassnig, Caroline; Meissl, Katrin; Amenitsch, Lena; Lederer, Therese; Pohl, Elena; Gotthardt, Dagmar; Bock, Christoph; Decker, Thomas; Strobl, Birgit; Mueller, Mathias 分享 收藏 Lack of TYK2 signaling enhances host resistance to Candida albicans skin infectionMiranda, Sara; Lassnig, Caroline; Schmidhofer, Kristina; Kjartansdottir, Hroenn; Vogl, Claus; Tangermann, Simone; Tsymala, Irina; Babl, Verena; Mueller, Mathias; Kuchler, Karl; Strobl, Birgit 分享 收藏 Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcificationAlesutan, Ioana; Razazian, Mehdi; Luong, Trang T. D.; Estepa, Misael; Pitigala, Lakmi; Henze, Laura A.; Obereigner, Jakob; Mitter, Gregor; Zickler, Daniel; Schuchardt, Mirjam; Deisl, Christine; Makridakis, Manousos; Gollmann-Tepekoeylue, Can; Pasch, Andreas; Cejka, Daniel; Suessner, Susanne; Antlanger, Marlies; Bielesz, Bernhard; Mueller, Mathias; Vlahou, Antonia; Holfeld, Johannes; Eckardt, Kai-Uwe; Voelkl, Jakob 分享 收藏 分享 收藏 JAK-STAT signaling maintains homeostasis in T cells and macrophagesFortelny, Nikolaus; Farlik, Matthias; Fife, Victoria; Gorki, Anna-Dorothea; Lassnig, Caroline; Maurer, Barbara; Meissl, Katrin; Dolezal, Marlies; Boccuni, Laura; Geetha, Aarathy Ravi Sundar Jose; Akagha, Mojoyinola Joanna; Karjalainen, Anzhelika; Shoebridge, Stephen; Farhat, Asma; Mann, Ulrike; Jain, Rohit; Tikoo, Shweta; Zila, Nina; Esser-Skala, Wolfgang; Krausgruber, Thomas; Sitnik, Katarzyna; Penz, Thomas; Hladik, Anastasiya; Suske, Tobias; Zahalka, Sophie; Senekowitsch, Martin; Barreca, Daniele; Halbritter, Florian; Macho-Maschler, Sabine; Weninger, Wolfgang; Neubauer, Heidi A.; Moriggl, Richard; Knapp, Sylvia; Sexl, Veronika; Strobl, Birgit; Decker, Thomas; Mueller, Mathias; Bock, Christoph 分享 收藏 Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia过度活跃的STAT5劫持T细胞受体信号并驱动未成熟的T细胞急性淋巴细胞白血病Suske, Tobias; Sorger, Helena; Manhart, Gabriele; Ruge, Frank; Prutsch, Nicole; Zimmerman, Mark W.; Eder, Thomas; Abdallah, Diaaeldin I.; Maurer, Barbara; Wagner, Christina; Schoenefeldt, Susann; Spirk, Katrin; Pichler, Alexander; Pemovska, Tea; Schweicker, Carmen; Poeloeske, Daniel; Hubanic, Emina; Jungherz, Dennis; Mueller, Tony Andreas; Aung, Myint Myat Khine; Orlova, Anna; Pham, Ha Thi Thanh; Zimmel, Kerstin; Krausgruber, Thomas; Bock, Christoph; Mueller, Mathias; Dahlhoff, Maik; Boersma, Auke; Ruelicke, Thomas; Fleck, Roman; Araujo, Elvin Dominic de; Gunning, Patrick Thomas; Aittokallio, Tero; Mustjoki, Satu; Sanda, Takaomi; Hartmann, Sylvia; Grebien, Florian; Hoermann, Gregor; Haferlach, Torsten; Staber, Philipp Bernhard; Neubauer, Heidi Anne; Look, Alfred Thomas; Herling, Marco; Moriggl, Richard 分享 收藏 Transmission-selective muscle pathology induced by the active propagation of mutant huntingtin across the human neuromuscular synapseDinamarca, Margarita C.; Colombo, Laura; Brykczynska, Urszula; Grimm, Amandine; Fruh, Isabelle; Hossain, Imtiaz; Gabriel, Daniela; Eckert, Anne; Mueller, Matthias; Pecho-Vrieseling, Eline 分享 收藏 分享 收藏 Regulation of NO Synthesis, Local Inflammation, and Innate Immunity to Pathogens by BET Family ProteinsBET家族蛋白对NO合成、局部炎症和病原体先天免疫的调控Wienerroither, Sebastian; Rauch, Isabella; Rosebrock, Felix; Jamieson, Amanda M.; Bradner, James; Muhar, Matthias; Zuber, Johannes; Mueller, Mathias; Decker, Thomas 分享 收藏 Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III InterferonsIRF9在肠道炎症中的非规范作用: 超过I型和III型干扰素Rauch, Isabella; Rosebrock, Felix; Hainzl, Eva; Heider, Susanne; Majoros, Andrea; Wienerroither, Sebastian; Strobl, Birgit; Stockinger, Silvia; Kenner, Lukas; Mueller, Mathias; Decker, Thomas 分享 收藏 STAT1β Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate ImmunitySemper, Christian; Leitner, Nicole R.; Lassnig, Caroline; Parrini, Matthias; Mahlakoiv, Tanel; Rammerstorfer, Michael; Lorenz, Karin; Rigler, Doris; Mueller, Simone; Kolbe, Thomas; Vogl, Claus; Ruelicke, Thomas; Staeheli, Peter; Decker, Thomas; Mueller, Mathias; Strobl, Birgit 分享 收藏 Identification of marker genes to monitor residual iPSCs in iPSC-derived productsLemmens, Myriam; Perner, Juliane; Potgeter, Leon; Zogg, Michael; Thiruchelvam, Sineha; Mueller, Matthias; Doll, Thierry; Werner, Annick; Gilbart, Yoann; Couttet, Philippe; Martus, Hans-Jorg; Libertini, Silvana 分享 收藏 Stress signaling boosts interferon-induced gene transcription in macrophagesBoccuni, Laura; Podgorschek, Elke; Schmiedeberg, Moritz; Platanitis, Ekaterini; Traxler, Peter; Fischer, Philipp; Schirripa, Alessia; Novoszel, Philipp; Nebreda, Angel R.; Arthur, J. Simon C.; Fortelny, Nikolaus; Farlik, Matthias; Sexl, Veronika; Bock, Christoph; Sibilia, Maria; Kovarik, Pavel; Mueller, Mathias; Decker, Thomas 分享 收藏 Tyk2 is a tumor suppressor in colorectal cancerTyk2是结直肠癌的肿瘤抑制因子Moritsch, Stefan; Moedl, Bernadette; Scharf, Irene; Janker, Lukas; Zwolanek, Daniela; Timelthaler, Gerald; Casanova, Emilio; Sibilia, Maria; Mohr, Thomas; Kenner, Lukas; Herndler-Brandstetter, Dietmar; Gerner, Christopher; Mueller, Mathias; Strobl, Birgit; Eferl, Robert 分享 收藏 Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities重症肌无力的受体聚集和致病性补体激活取决于具有多种亚基特异性的抗体之间的协同作用Rose, Natalie; Holdermann, Sebastian; Callegari, Ilaria; Kim, Hyein; Fruh, Isabelle; Kappos, Ludwig; Kuhle, Jens; Muller, Matthias; Sanderson, Nicholas S. R.; Derfuss, Tobias 分享 收藏 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png)
NUCLEIC ACIDS RESEARCH.png)
