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L

Lee M

Wellcome Sanger Institute
H指数:48
被引数:1.0万

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Identification of genetic markers of quinine partial resistance in Plasmodium falciparum

鉴定恶性疟原虫中奎宁部分耐药性的遗传标记

Nature Microbiology
IF19.4
2026-07-060
OAAI
Mariko Kanai; Sachel Mok; Tomas Yeo; Melanie J. Shears; Jin H. Jeon; Sunil K. Narwal; Leila S. Ross; Kharizta Wiradiputri; Meseret T. Haile; Abhai K. Tripathi; Godfree Mlambo; Jonathan Kim; Eva Gil-Iturbe; Heekuk Park; Tolla Ndiaye; John Okombo; Kurt E. Ward; Felix D. Rozenberg; Kate J. Fairhurst; Sydney M. Gavula; Talia S. Bloxham; Jessica L. Bridgford; Tanaya Sheth; Manuel Llinás; Marcus C. S. Lee; Jennifer L. Small-Saunders; Filippo Mancia; Matthias Quick; Anne-Catrin Uhlemann; Photini Sinnis; David Armand Fidock
A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一类具有抗疟活性和潜在新型作用机制的新型口服生物利用型苯甘氨酸-苯并硼杂唑偶联物

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2025-12-010
PRE
Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; Da Rocha, Shante; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C. S.; Wittlin, Sergio; Llinas, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Chibale, Kelly
Mechanistic insights into dual-active liver and blood-stage antiplasmodials

双活性肝期和血期抗疟原虫药物的机制研究

MBIO
IF4.7
2025-11-010
PRE
Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R.; Chen, Daisy; Plater, Andrew; Post, John; De Lin; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C.; Gamo, Fransisco-Javier; Baragana, Beatriz; Winzeler, Elizabeth A.; Lee, Marcus C. S.
Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

靶向Aurora Kinases这一关键细胞周期调控因子，以递送针对Plasmodium Falciparum的多阶段抗疟药。

Angewandte Chemie International Edition
IF16.9
2025-10-230
OAAI
Henrico Langeveld; Keletso Maepa; Marché Maree; Jessica L. Thibaud; Nicolaas Salomane; Rosie Bridgwater; Mufuliat T. Famodimu; Luiz C. Godoy; Charisse Flerida A. Pasaje; Nonlawat Boonyalai; Mariana Laureano de Souza; Justin Fong; Tayla Rabie; Mariëtte van der Watt; Rensu P. Theart; Sonja Ghidelli-Disse; Jacquin C. Niles; Marcus C. S. Lee; Elizabeth A. Winzeler; Michael J. Delves; Kelly Chibale; Kathryn J. Wicht; Lauren B. Coulson; Lyn-Marié Birkholtz
Optimization of 2; 8-Diaryl-1; 5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

2;8-二芳基-1;5-萘啶的优化：作为恶性疟原虫磷脂酰肌醇4-激酶抑制剂的改进ADME性质和体内疗效

Journal of Medicinal Chemistry
IF6.8
2025-10-070
OAAI
Godwin A. Dziwornu; Donald Seanego; Stephen Fienberg; Venkata S. Sypu; Nicolaas Salomane; Liezl Krugmann; Dale Taylor; Keabetswe Masike; Mathew Njoroge; Nonlawat Boonyalai; Marcus C. S. Lee; Luiz C. Godoy; Charisse Flerida Pasaje; Jacquin C. Niles; Gregory S. Basarab; Lauren B. Coulson; Sandeep R. Ghorpade; Kelly Chibale
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

ROM8和CSC1易受突变影响的N-芳基乙酰胺类化合物的抗疟活性的优化与表征

Journal of Medicinal Chemistry
IF6.8
2025-07-180
OA
William Nguyen; Coralie Boulet; Madeline G. Dans; Katie Loi; Kate E. Jarman; Claudia B. G. Barnes; Tomas Yeo; Tanaya Sheth; Partha Mukherjee; Arnish Chakraborty; Mufuliat T. Famodimu; Michael J. Delves; Harry Pollard; Colin J. Sutherland; Rachael Coyle; Nicole Sevilleno; Nonlawat Boonyalai; Marcus C. S. Lee; Tayla Rabie; Lyn-Marié Birkholtz; Delphine Baud; Stephen Brand; Mrittika Chowdury; Tania F. de Koning-Ward; David A. Fidock; Paul R. Gilson; Brad E. Sleebs
Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology
IF7.2
2025-07-070
PRE
Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

N-乙酰胺基吲哚类化合物的优化与表征：靶向PfATP4的抗疟疾药物研究

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-140
PRE
Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

一种具有多阶段抗疟活性且与PfCRT和PfMDR1突变体缺乏交叉抗性的新型4-氨基喹啉化学型

PLOS PATHOGENS
IF4.9
2024-10-290
OAAI
Ferreira, Leticia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, Eva; Coyle, Rachael; Andrade, Carolina Horta; Sunnerhagen, Per; Bargieri, Daniel Youssef; Prudencio, Miguel; Quick, Matthias; Cravo, Pedro V.; Lee, Marcus C. S.; Fidock, David A.; Costa, Fabio Trindade Maranhao
β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling
ACS INFECTIOUS DISEASES
IF3.8
2024-10-281
PRE
Mathew, Jopaul; Zhou, Bo; Haney, Reagan S.; Kunz, Kevin A.; Do Amaral, Leticia S.; Chowdhury, Rudraneel Roy; Butler, Joshua H.; Li, Haibo; Chakraborty, Amarraj J.; Tabassum, Anika; Bremers, Emily K.; Merino, Emilio F.; Coyle, Rachael; Lee, Marcus C. S.; Baud, Delphine; Brand, Stephen; Totrov, Maxim; Cassera, Maria Belen; Carlier, Paul R.
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-253
OAAI
Dziwornu, Godwin Akpeko; Seanego, Donald; Fienberg, Stephen; Clements, Monica; Ferreira, Jasmin; Sypu, Venkata S.; Samanta, Sauvik; Bhana, Ashlyn D.; Korkor, Constance M.; Garnie, Larnelle F.; Teixeira, Nicole; Wicht, Kathryn J.; Taylor, Dale; Olckers, Ronald; Njoroge, Mathew; Gibhard, Liezl; Salomane, Nicolaas; Wittlin, Sergio; Mahato, Rohit; Chakraborty, Arnish; Sevilleno, Nicole; Coyle, Rachael; Lee, Marcus C. S.; Godoy, Luiz C.; Pasaje, Charisse Flerida; Niles, Jacquin C.; Reader, Janette; van der Watt, Mariette; Birkholtz, Lyn-Marie; Bolscher, Judith M.; de Bruijni, Marloes H. C.; Coulson, Lauren B.; Basarab, Gregory S.; Ghorpade, Sandeep R.; Chibale, Kelly
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
NATURE COMMUNICATIONS
IF15.7
2024-01-312
OAAI
Xie, Stanley C.; Wang, Yinuo; Morton, Craig J.; Metcalfe, Riley D.; Dogovski, Con; Pasaje, Charisse Flerida A.; Dunn, Elyse; Luth, Madeline R.; Kumpornsin, Krittikorn; Istvan, Eva S.; Park, Joon Sung; Fairhurst, Kate J.; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N.; Klug, Dana M.; Rutledge, Peter J.; Godoy, Luiz C.; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L.; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P.; Maity, Bikash C.; Thomson, Patrick; Foley, Thomas; Tan, Derek S.; Niles, Jacquin C.; Han, Byung Woo; Goldberg, Daniel E.; Burrows, Jeremy; Fidock, David A.; Lee, Marcus C. S.; Winzeler, Elizabeth A.; Griffin, Michael D. W.; Todd, Matthew H.; Tilley, Leann

研究方向

暂未获取到该数据
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万
E
Elizabeth A. Winzeler
H 指数:83论文数:356被引数:3.6万
F
Francisco‐Javier Gamo
H 指数:40论文数:153被引数:7,823
J
Jacquin C. Niles
H 指数:36论文数:111被引数:5,260
C
Charisse Flerida A. Pasaje
H 指数:23论文数:111被引数:2,047
R
Rachael Coyle
H 指数:10论文数:31被引数:401
M
Manuel Llinás
H 指数:61论文数:259被引数:1.3万
K
Krittikorn Kümpornsin
H 指数:15论文数:37被引数:930
S
Sabine Ottilie
H 指数:31论文数:69被引数:3,473
M
Madeline R. Luth
H 指数:19论文数:47被引数:1,362