未登录 Bisamidine Derivatives as Candidates for Tegumentary Leishmaniasis Therapy: Phenotypic Screening in Infection of Macrophages and Mechanistic Insights with Dual RNA-seq 双脒类衍生物作为皮肤利什曼病治疗候选药物：巨噬细胞感染表型筛选与双RNA测序机制研究 Agripino, Joice; Tahira, Ana C.; de Souza, Luciana Angelo; Silva e Bastos, Matheus; Sauer, Benjamin; Schmidt, Matthias; Bressan, Gustavo Costa; de Souza Vasconcellos, Raphael; Sippl, Wolfgang; Pierce, Raymond; Sena Amaral, Murilo; Verjovski-Almeida, Sergio; Rangel Fietto, Juliana Lopes 分享 收藏
Histone Deacetylase Inhibitors Show a Potential Leishmanicidal Effect against Leishmania braziliensis in a Mouse Infection Model and Lead to Less Toxicity than Glucantime 组蛋白去乙酰化酶抑制剂在鼠感染模型中对Leishmania braziliensis显示出潜在的杀利什曼原虫作用，且其毒性低于Glucantime。 de Souza, LA; Andrade, LKR; Agripino, JD; da Silva, VHF; Emerick, SD; da Silva, AC; Pereira, LC; Lima, GDD; Garcia, IR; Souza, AC; Heimburg, T; da Silva, EDM; de Oliveira, LL; Ervilha, LOG; Machado-Neves, M; Bastos, MSE; Vasconcellos, RD; Bressan, G; Silva, A Jr; Pierce, RJ; Sippl, W; Fietto, JLR 分享 收藏
Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction (vol 14, 1079855, 2023) Coelho, Fernanda Sales; Gava, Sandra Grossi; Andrade, Luiza Freire; Geraldo, Juliana Assis; Tavares, Naiara Clemente; Lunkes, Felipe Miguel Nery; Neves, Renata Heisler; Machado-Silva, Jose Roberto; Pierce, Raymond J.; Oliveira, Guilherme; Mourao, Marina Moraes 分享 收藏
Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction Coelho, Fernanda Sales; Gava, Sandra Grossi; Andrade, Luiza Freire; Geraldo, Juliana Assis; Tavares, Naiara Clemente; Lunkes, Felipe Miguel Nery; Neves, Renata Heisler; Machado-Silva, Jose Roberto; Pierce, Raymond J.; Oliveira, Guilherme; Mourao, Marina Moraes 分享 收藏
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Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis Ghazy, Ehab; Heimburg, Tino; Lancelot, Julien; Zeyen, Patrik; Schmidtkunz, Karin; Truhn, Anne; Darwish, Salma; Simoben, Conrad, V; Shaik, Tajith B.; Erdmann, Frank; Schmidt, Matthias; Robaa, Dina; Romier, Christophe; Jung, Manfred; Pierce, Raymond; Sippl, Wolfgang 分享 收藏
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2 Marek, Martin; Ramos-Morales, Elizabeth; Picchi-Constante, Gisele F. A.; Bayer, Theresa; Norstrom, Carina; Herp, Daniel; Sales-Junior, Policarpo A.; Guerra-Slompo, Eloise P.; Hausmann, Kristin; Chakrabarti, Alokta; Shaik, Tajith B.; Merz, Annika; Troesch, Edouard; Schmidtkunz, Karin; Goldenberg, Samuel; Pierce, Raymond J.; Mourao, Marina M.; Jung, Manfred; Schultz, Johan; Sippl, Wolfgang; Zanchin, Nilson I. T.; Romier, Christophe 分享 收藏
Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni Pagliazzo, Lucile; Caby, Stephanie; Lancelot, Julien; Salome-Desnoulez, Sophie; Saliou, Jean-Michel; Heimburg, Tino; Chassat, Thierry; Cailliau, Katia; Sippl, Wolfgang; Vicogne, Jerome; Pierce, Raymond J. 分享 收藏
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis de Souza, Luciana Angelo; e Bastos, Matheus Silva; Agripino, Joice de Melo; Onofre, Thiago Souza; Apaza Calla, Lourdes Fanny; Heimburg, Tino; Ghazy, Ehab; Bayer, Theresa; Ferraz da Silva, Victor Hugo; Ribeiro, Paula Dutra; de Oliveira, Leandro Licursi; Bressan, Gustavo Costa; de Almeida Lamego, Marcia Rogeria; Silva-Junior, Abelardo; Vasconcellos, Raphael de Souza; Suarez-Fontes, Ana Marcia; Almeida-Silva, Juliana; Vannier-Santos, Marcos Andre; Pierce, Raymond; Sippl, Wolfgang; Rangel Fietto, Juliana Lopes 分享 收藏
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni Carneiro, Vitor Coutinho; de Abreu Silva, Isabel Caetano; Amaral, Murilo Sena; Pereira, Adriana S. A.; Silveira, Gilbert Oliveira; Pires, David da Silva; Verjovski-Almeida, Sergio; Dekker, Frank J.; Rotili, Dante; Mai, Antonello; Lopes-Torres, Eduardo Jose; Robaa, Dina; Sippl, Wolfgang; Pierce, Raymond J.; Borrello, M. Teresa; Ganesan, A.; Lancelot, Julien; Thiengo, Silvana; Fernandez, Monica Ammon; Revoredo Vicentino, Amanda Roberta; Mourao, Marina Moraes; Coelho, Fernanda Sales; Fantappie, Marcelo Rosado 分享 收藏
Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors Kalinin, Dmitrii, V; Jana, Sunit K.; Pfafenrot, Maxim; Chakrabarti, Alokta; Melesina, Jelena; Shaik, Tajith B.; Lancelot, Julien; Pierce, Raymond J.; Sippl, Wolfgang; Romier, Christophe; Jung, Manfred; Holl, Ralph 分享 收藏
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2) Monaldi, Dania; Rotili, Dante; Lancelot, Julien; Marek, Martin; Woessner, Nathalie; Lucidi, Alessia; Tomaselli, Daniela; Ramos-Morales, Elizabeth; Romier, Christophe; Pierce, Raymond J.; Mai, Antonello; Jung, Manfred 分享 收藏
Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism Pereira, Adriana S. A.; Amaral, Murilo S.; Vasconcelos, Elton J. R.; Pires, David S.; Asif, Huma; dasilva, Lucas F.; Morales-Vicente, David A.; Carneiro, Vitor C.; Angeli, Claudia B.; Palmisano, Giuseppe; Fantappie, Marcelo R.; Pierce, Raymond J.; Setubal, Joao C.; Verjovski-Almeida, Sergio 分享 收藏
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants Marek, Martin; Shaik, Tajith B.; Heimburg, Tino; Chakrabarti, Alokta; Lancelot, Julien; Ramos-Morales, Elizabeth; Da Veiga, Cyrielle; Kalinin, Dmitrii; Melesina, Jelena; Robaa, Dina; Schmidtkunz, Karin; Suzuki, Takayoshi; Holl, Ralph; Ennifar, Eric; Pierce, Raymond J.; Jung, Manfred; Sippl, Wolfgang; Romier, Christophe 分享 收藏
Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis Bayer, Theresa; Chakrabarti, Alokta; Lancelot, Julien; Shaik, Tajith B.; Hausmann, Kristin; Melesina, Jelena; Schmidtkunz, Karin; Marek, Martin; Erdmann, Frank; Schmidt, Matthias; Robaa, Dina; Romier, Christophe; Pierce, Raymond J.; Jung, Manfred; Sippl, Wolfgang 分享 收藏
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing Simoben, Conrad V.; Robaa, Dina; Chakrabarti, Alokta; Schmidtkunz, Karin; Marek, Martin; Lancelot, Julien; Kannan, Srinivasaraghavan; Melesina, Jelena; Shaik, Tajith B.; Pierce, Raymond J.; Romier, Christophe; Jung, Manfred; Sippl, Wolfgang 分享 收藏
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Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth Chua, Ming Jang; Arnold, Megan S. J.; Xu, Weijun; Lancelot, Julien; Lamotte, Suzanne; Spaeth, Gerald F.; Prina, Eric; Pierce, Raymond J.; Fairlie, David P.; Skinner-Adams, Tina S.; Andrews, Katherine T. 分享 收藏
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