未登录 Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors Kent, Deniz; Ng, Soon Seng; Syanda, Adam M.; Khoshkenar, Payam; Ronzoni, Riccardo; Li, Chao Zheng; Zieger, Marina; Greer, Cindy; Hatch, Stephanie; Segal, Joe; Blackford, Samuel J., I; Im, Yu Ri; Chowdary, Vivek; Ismali, Taylor; Danovi, Davide; Lewis, Patrick A.; Irving, James A.; Sahdeo, Sunil; Lomas, David A.; Ebner, Daniel; Mueller, Christian; Rashid, S. Tamir 分享 收藏
CHK1 inhibition exacerbates replication stress induced by IGF blockade Wu, Xiaoning; Seraia, Elena; Hatch, Stephanie B.; Wan, Xiao; Ebner, Daniel V.; Aroldi, Francesca; Jiang, Yanyan; Ryan, Anderson J.; Bogenrieder, Thomas; Weyer-Czernilofsky, Ulrike; Rieunier, Guillaume; Macaulay, Valentine M. 分享 收藏
Quantitative SARS-CoV-2 anti-spike responses to Pfizer-BioNTech and Oxford-AstraZeneca vaccines by previous infection status 辉瑞-BioNTech和牛津-阿斯利康疫苗对既往感染状况的定量SARS-CoV-2抗尖峰反应 Eyre, David W.; Lumley, Sheila F.; Wei, Jia; Cox, Stuart; James, Tim; Justice, Anita; Jesuthasan, Gerald; O'Donnell, Denise; Howarth, Alison; Hatch, Stephanie B.; Marsden, Brian D.; Jones, E. Yvonne; Stuart, David, I; Ebner, Daniel; Hoosdally, Sarah; Crook, Derrick W.; Peto, Tim E. A.; Walker, Timothy M.; Stoesser, Nicole E.; Matthews, Philippa C.; Pouwels, Koen B.; Walker, A. Sarah; Jeffery, Katie 分享 收藏
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An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status 通过抗体和疫苗接种状况对医护人员新型冠状病毒 (SARS-CoV-2) 感染和B.1.1.7变异感染发生率的观察性队列研究 Lumley, Sheila F.; Rodger, Gillian; Constantinides, Bede; Sanderson, Nicholas; Chau, Kevin K.; Street, Teresa L.; O'Donnell, Denise; Howarth, Alison; Hatch, Stephanie B.; Marsden, Brian D.; Cox, Stuart; James, Tim; Warren, Fiona; Peck, Liam J.; Ritter, Thomas G.; de Toledo, Zoe; Warren, Laura; Axten, David; Cornall, Richard J.; Jones, E. Yvonne; Stuart, David, I; Screaton, Gavin; Ebner, Daniel; Hoosdally, Sarah; Chand, Meera; Crook, Derrick W.; O'donnell, Anne-Marie; Conlon, Christopher P.; Pouwels, Koen B.; Walker, A. Sarah; Peto, Tim E. A.; Hopkins, Susan; Walker, Timothy M.; Stoesser, Nicole E.; Matthews, Philippa C.; Jeffery, Katie; Eyre, David W. 分享 收藏
Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections Eyre, David W.; Lumley, Sheila F.; O'Donnell, Denise; Stoesser, Nicole E.; Matthews, Philippa C.; Howarth, Alison; Hatch, Stephanie B.; Marsden, Brian D.; Cox, Stuart; James, Tim; Cornall, Richard J.; Stuart, David I.; Screaton, Gavin; Ebner, Daniel; Crook, Derrick W.; Conlon, Christopher P.; Jeffery, Katie; Walker, Timothy M.; Peto, Timothy E. A. 分享 收藏
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers Lumley, S. F.; O'Donnell, D.; Stoesser, N. E.; Matthews, P. C.; Howarth, A.; Hatch, S. B.; Marsden, B. D.; Cox, S.; James, T.; Warren, F.; Peck, L. J.; Ritter, T. G.; de Toledo, Z.; Warren, L.; Axten, D.; Cornall, R. J.; Jones, E. Y.; Stuart, D. I.; Screaton, G.; Ebner, D.; Hoosdally, S.; Chand, M.; Crook, D. W.; O'Donnell, A. -M.; Conlon, C. P.; Pouwels, K. B.; Walker, A. S.; Peto, T. E. A.; Hopkins, S.; Walker, T. M.; Jeffery, K.; Eyre, D. W. 分享 收藏
Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction Rieunier, Guillaume; Wu, Xiaoning; Harris, Letitia E.; Mills, Jack, V; Nandakumar, Ashwin; Colling, Laura; Seraia, Elena; Hatch, Stephanie B.; Ebner, Daniel, V; Folkes, Lisa K.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Ryan, Anderson J.; Macaulay, Valentine M. 分享 收藏
The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers 个体医护人员新型冠状病毒 (SARS-CoV-2) 抗体反应的持续时间，动态和决定因素 Lumley, Sheila F.; Wei, Jia; O'Donnell, Denise; Stoesser, Nicole E.; Matthews, Philippa C.; Howarth, Alison; Hatch, Stephanie B.; Marsden, Brian D.; Cox, Stuart; James, Tim; Peck, Liam J.; Ritter, Thomas G.; de Toledo, Zoe; Cornall, Richard J.; Jones, E. Yvonne; Stuart, David, I; Screaton, Gavin; Ebner, Daniel; Hoosdally, Sarah; Crook, Derrick W.; Conlon, Christopher P.; Pouwels, Koen B.; Walker, A. Sarah; Peto, Tim E. A.; Walker, Timothy M.; Jeffery, Katie; Eyre, David W. 分享 收藏
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 Lumley, Sheila F.; Eyre, David W.; McNaughton, Anna L.; Howarth, Alison; Hoosdally, Sarah; Hatch, Stephanie B.; Kavanagh, James; Chau, Kevin K.; Downs, Louise O.; Cox, Stuart; Dunn, Laura; Justice, Anita; Wareing, Susan; Dingle, Kate; Rudkin, Justine; Auckland, Kathryn; Fyfe, Alexander; Bolton, Jai; Paton, Robert; Mentzer, Alexander J.; Jeffery, Katie; Andersson, Monique, I; James, Tim; Peto, Tim E. A.; Marsden, Brian D.; Screaton, Gavin; Cornall, Richard J.; Klenerman, Paul; Ebner, Daniel; Stuart, David, I; Crook, Derrick W.; Stoesser, Nicole; Kennedy, Stephen H.; Thompson, Craig; Gupta, Sunetra; Matthews, Philippa C. 分享 收藏
Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments 患者来源的恶性胸膜间皮瘤细胞培养: 推进生物标志物驱动治疗的工具 Kanellakis, Nikolaos, I; Asciak, Rachelle; Hamid, Megat Abd; Yao, Xuan; McCole, Mark; McGowan, Simon; Seraia, Elena; Hatch, Stephanie; Hallifax, Rob J.; Mercer, Rachel M.; Bedawi, Eihab O.; Jones, Stephanie; Verrill, Clare; Dobson, Melissa; George, Vineeth; Stathopoulos, Georgios T.; Peng, Yanchun; Ebner, Daniel; Dong, Tao; Rahman, Najib M.; Psallidas, Ioannis 分享 收藏
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study Eyre, David W.; Lumley, Sheila F.; O'Donnell, Denise; Campbell, Mark; Sims, Elizabeth; Lawson, Elaine; Warren, Fiona; James, Tim; Cox, Stuart; Howarth, Alison; Doherty, George; Hatch, Stephanie B.; Kavanagh, James; Chau, Kevin K.; Fowler, Philip W.; Swann, Jeremy; Volk, Denis; Yang-Turner, Fan; Stoesser, Nicole; Matthews, Philippa C.; Dudareva, Maria; Davies, Timothy; Shaw, Robert H.; Peto, Leon; Downs, Louise O.; Vogt, Alexander; Amini, Ali; Young, Bernadette C.; Drennan, Philip George; Mentzer, Alexander J.; Skelly, Donal T.; Karpe, Fredrik; Neville, Matt J.; Andersson, Monique; Brent, Andrew J.; Jones, Nicola; Ferreira, Lucas Martins; Christott, Thomas; Marsden, Brian D.; Hoosdally, Sarah; Cornall, Richard; Crook, Derrick W.; Stuart, David, I; Screaton, Gavin; Peto, Timothy E. A.; Holthof, Bruno; O'Donnell, Anne-Marie; Ebner, Daniel; Conlon, Christopher P.; Jeffery, Katie; Walker, Timothy M. 分享 收藏
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition Burdova, Kamila; Yang, Hongbin; Faedda, Roberta; Hume, Samuel; Chauhan, Jagat; Ebner, Daniel; Kessler, Benedikt M.; Vendrell, Iolanda; Drewry, David H.; Wells, Carrow, I; Hatch, Stephanie B.; Dianov, Grigory L.; Buffa, Francesca M.; D'Angiolella, Vincenzo 分享 收藏
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications Ong, John; Serra, Maria Paola; Segal, Joe; Cujba, Ana-Maria; Ng, Soon Seng; Butler, Richard; Millar, Val; Hatch, Stephanie; Zimri, Salman; Koike, Hiroyuki; Chan, Karen; Bonham, Andrew; Walk, Michelle; Voss, Ty; Heaton, Nigel; Mitry, Ragai; Dhawan, Anil; Ebner, Daniel; Danovi, Davide; Nakauchi, Hiromitsu; Rashid, S. Tamir 分享 收藏
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7 组蛋白赖氨酸脱甲基酶KDM2/7的高选择性细胞活性抑制剂的发现 Gerken, Philip A.; Wolstenhulme, Jamie R.; Tumber, Anthony; Hatch, Stephanie B.; Zhang, Yijia; Mueller, Susanne; Chandler, Shane A.; Mair, Barbara; Li, Fengling; Nijman, Sebastian M. B.; Konietzny, Rebecca; Szommer, Tamas; Yapp, Clarence; Fedorov, Oleg; Benesch, Justin L. P.; Vedadi, Masoud; Kessler, Benedikt M.; Kawamura, Akane; Brennan, Paul E.; Smith, Martin D. 分享 收藏
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides Kawamura, Akane; Muenzel, Martin; Kojima, Tatsuya; Yapp, Clarence; Bhushan, Bhaskar; Goto, Yuki; Tumber, Anthony; Katoh, Takayuki; King, Oliver N. F.; Passioura, Toby; Walport, Louise J.; Hatch, Stephanie B.; Madden, Sarah; Mueller, Susanne; Brennan, Paul E.; Chowdhury, Rasheduzzaman; Hopkinson, Richard J.; Suga, Hiroaki; Schofield, Christopher J. 分享 收藏
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells Tumber, Anthony; Nuzzi, Andrea; Hookway, Edward S.; Hatch, Stephanie B.; Velupillai, Srikannathasan; Johansson, Catrine; Kawamura, Akane; Savitsky, Pavel; Yapp, Clarence; Szykowska, Aleksandra; Wu, Na; Bountra, Chas; Strain-Damerell, Claire; Burgess-Brown, Nicola A.; Ruda, Gian Filippo; Fedorov, Oleg; Munro, Shonagh; England, Katherine S.; Nowak, Radoslaw P.; Schofield, Christopher J.; La Thangue, Nicholas B.; Pawlyn, Charlotte; Davies, Faith; Morgan, Gareth; Athanasou, Nick; Mueller, Susanne; Oppermann, Udo; Brennan, Paul E. 分享 收藏
Assessing histone demethylase inhibitors in cells: lessons learned Hatch, Stephanie B.; Yapp, Clarence; Montenegro, Raquel C.; Savitsky, Pavel; Gamble, Vicki; Tumber, Anthony; Ruda, Gian Filippo; Bavetsias, Vassilios; Fedorov, Oleg; Atrash, Butrus; Raynaud, Florence; Lanigan, Rachel; Carmichael, LeAnne; Tomlin, Kathy; Burke, Rosemary; Westaway, Susan M.; Brown, Jack A.; Prinjha, Rab K.; Martinez, Elisabeth D.; Oppermann, Udo; Schofield, Christopher J.; Bountra, Chas; Kawamura, Akane; Blagg, Julian; Brennan, Paul E.; Rossanese, Olivia; Mueller, Susanne 分享 收藏
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors Bavetsias, Vassilios; Lanigan, Rachel M.; Ruda, Gian Filippo; Atrash, Butrus; McLaughlin, Mark G.; Tumber, Anthony; Mok, N. Yi; Le Bihan, Yann-Vai; Dempster, Sally; Boxall, Katherine J.; Jeganathan, Fiona; Hatch, Stephanie B.; Savitsky, Pavel; Velupillai, Srikannathasan; Krojer, Tobias; England, Katherine S.; Sejberg, Jimmy; Thai, Ching; Donovan, Adam; Pal, Akos; Scozzafava, Giuseppe; Bennett, James M.; Kawamura, Akane; Johansson, Catrine; Szykowska, Aleksandra; Gileadi, Carina; Burgess-Brown, Nicola A.; von Delft, Frank; Oppermann, Udo; Walters, Zoe; Shipley, Janet; Raynaud, Florence I.; Westaway, Susan M.; Prinjha, Rab K.; Fedorov, Oleg; Burke, Rosemary; Schofield, Christopher J.; Westwood, Isaac M.; Bountra, Chas; Mueller, Susanne; van Montfort, Rob L. M.; Brennan, Paul E.; Blagg, Julian 分享 收藏
XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: Suitability as a biomarker for patient selection Hatch, Stephanie B.; Swift, Lonnie P.; Caporali, Simona; Carter, Rebecca; Hill, Esme J.; MacGregor, Thomas P.; D'Atri, Stefania; Middleton, Mark R.; McHugh, Peter J.; Sharma, Ricky A. 分享 收藏
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