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Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy Lutz, Raphael; Gruenschlaeger, Florian; Simon, Malte; Awwad, Mohamed H. S.; Bauer, Marcus; Yousefian, Schayan; Beumer, Niklas; Jopp-Saile, Lea; Sedlmeier, Anastasia; Solee-Boldo, Llorenc; Avanesyan, Bogdan; Vonficht, Dominik; Stelmach, Patrick; Steinbuss, Georg; Boch, Tobias; Steiger, Simon; Baertsch, Marc-Andrea; Prokoph, Nina; Rippe, Karsten; Durie, Brian G. M.; Wickenhauser, Claudia; Trumpp, Andreas; Mueller-Tidow, Carsten; Huebschmann, Daniel; Weinhold, Niels; Raab, Marc S.; Brors, Benedikt; Goldschmidt, Hartmut; Imbusch, Charles D.; Hundemer, Michael; Haas, Simon 分享 收藏
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype 单细胞多组学分析揭示具有复杂核型的急性髓系白血病的动态克隆进化和可靶向表型 Leppae, Aino-Maija; Grimes, Karen; Jeong, Hyobin; Huang, Frank Y.; Andrades, Alvaro; Waclawiczek, Alexander; Boch, Tobias; Jauch, Anna; Renders, Simon; Stelmach, Patrick; Mueller-Tidow, Carsten; Karpova, Darja; Sohn, Markus; Gruenschlaeger, Florian; Hasenfeld, Patrick; Benito Garagorri, Eva; Thiel, Vera; Dolnik, Anna; Rodriguez-Martin, Bernardo; Bullinger, Lars; Mrozek, Krzysztof; Eisfeld, Ann-Kathrin; Kraemer, Alwin; Sanders, Ashley D.; Korbel, Jan O.; Trumpp, Andreas 分享 收藏
Proteomic signatures improve risk prediction for common and rare diseases 蛋白质组学特征改善了常见和罕见疾病的风险预测 Carrasco-Zanini, Julia; Pietzner, Maik; Davitte, Jonathan; Surendran, Praveen; Croteau-Chonka, Damien C.; Robins, Chloe; Torralbo, Ana; Tomlinson, Christopher; Gruenschlaeger, Florian; Fitzpatrick, Natalie; Ytsma, Cai; Kanno, Tokuwa; Gade, Stephan; Freitag, Daniel; Ziebell, Frederik; Haas, Simon; Denaxas, Spiros; Betts, Joanna C.; Wareham, Nicholas J.; Hemingway, Harry; Scott, Robert A.; Langenberg, Claudia 分享 收藏
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities Ramberger, Evelyn; Sapozhnikova, Valeriia; Ng, Yuen Lam Dora; Dolnik, Anna; Ziehm, Matthias; Popp, Oliver; Straeng, Eric; Kull, Miriam; Gruenschlaeger, Florian; Krueger, Josefine; Benary, Manuela; Mueller, Sina; Gao, Xiang; Murgai, Arunima; Haji, Mohamed; Schmidt, Annika; Lutz, Raphael; Nogai, Axel; Braune, Jan; Laue, Dominik; Langer, Christian; Khandanpour, Cyrus; Bassermann, Florian; Doehner, Hartmut; Engelhardt, Monika; Straka, Christian; Hundemer, Michael; Beule, Dieter; Haas, Simon; Keller, Ulrich; Einsele, Hermann; Bullinger, Lars; Knop, Stefan; Mertins, Philipp; Kroenke, Jan 分享 收藏
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation Bouman, Brigitte J.; Demerdash, Yasmin; Sood, Shubhankar; Gruenschlaeger, Florian; Pilz, Franziska; Itani, Abdul R.; Kuck, Andrea; Marot-Lassauzaie, Valerie; Haas, Simon; Haghverdi, Laleh; Essers, Marieke A. G. 分享 收藏
A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo Demel, Uta Margareta; Lutz, Raphael; Sujer, Stefanie; Demerdash, Yasmin; Sood, Shubhankar; Gruenschlaeger, Florian; Kuck, Andrea; Werner, Paula; Blaszkiewicz, Sandra; Uckelmann, Hannah Julia; Haas, Simon; Essers, Marieke Alida Gertruda 分享 收藏
Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer Demel, Uta M.; Boeger, Marlitt; Yousefian, Schayan; Grunert, Corinna; Zhang, Le; Hotz, Paul W.; Gottschlich, Adrian; Koese, Hazal; Isaakidis, Konstandina; Vonficht, Dominik; Gruenschlaeger, Florian; Rohleder, Elena; Wagner, Kristina; Doenig, Judith; Igl, Veronika; Brzezicha, Bernadette; Baumgartner, Francis; Habringer, Stefan; Loeber, Jens; Chapuy, Bjoern; Weidinger, Carl; Kobold, Sebastian; Haas, Simon; Busse, Antonia B.; Mueller, Stefan; Wirth, Matthias; Schick, Markus; Keller, Ulrich 分享 收藏
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool 抗原呈递保护造血干细胞池的完整性 Hernandez-Malmierca, Pablo; Vonficht, Dominik; Schnell, Alexandra; Uckelmann, Hannah J.; Bollhagen, Alina; Mahmoud, Mohamed A. A.; Landua, Sophie-Luise; van der Salm, Elise; Trautmann, Christine L.; Raffel, Simon; Gruenschlaeger, Florian; Lutz, Raphael; Ghosh, Michael; Renders, Simon; Correia, Nadia; Donato, Elisa; Dixon, Karin O.; Hirche, Christoph; Andresen, Carolin; Robens, Claudia; Werner, Paula S.; Boch, Tobias; Eisel, David; Osen, Wolfram; Pilz, Franziska; Przybylla, Adriana; Klein, Corinna; Buchholz, Frank; Milsom, Michael D.; Essers, Marieke A. G.; Eichmueller, Stefan B.; Hofmann, Wolf-Karsten; Nowak, Daniel; Huebschmann, Daniel; Hundemer, Michael; Thiede, Christian; Bullinger, Lars; Mueller-Tidow, Carsten; Armstrong, Scott A.; Trumpp, Andreas; Kuchroo, Vijay K.; Haas, Simon 分享 收藏
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone Lutsik, Pavlo; Baude, Annika; Mancarella, Daniela; Oz, Simin; Kuhn, Alexander; Toth, Reka; Hey, Joschka; Toprak, Umut H.; Lim, Jinyeong; Viet Ha Nguyen; Jiang, Chao; Mayakonda, Anand; Hartmann, Mark; Rosemann, Felix; Breuer, Kersten; Vonficht, Dominik; Gruenschlaeger, Florian; Lee, Suman; Schuhmacher, Maren Kirstin; Kusevic, Denis; Jauch, Anna; Weichenhan, Dieter; Zustin, Jozef; Schlesner, Matthias; Haas, Simon; Park, Joo Hyun; Park, Yoon Jung; Oppermann, Udo; Jeltsch, Albert; Haller, Florian; Fellenberg, Joerg; Lindroth, Anders M.; Plass, Christoph 分享 收藏
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization 结合单细胞和空间转录组学揭示了分子，细胞和空间骨髓生态位组织 Baccin, Chiara; Al-Sabah, Jude; Velten, Lars; Helbling, Patrick M.; Gruenschlaeger, Florian; Hernandez-Malmierca, Pablo; Nombela-Arrieta, Cesar; Steinmetz, Lars M.; Trumpp, Andreas; Haas, Simon 分享 收藏
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness Wu, Jingxia; Ma, Sicong; Sandhoff, Roger; Ming, Yanan; Hotz-Wagenblatt, Agnes; Timmerman, Vincent; Bonello-Palot, Nathalie; Schlotter-Weigel, Beate; Auer-Grumbach, Michaela; Seeman, Pavel; Loescher, Wolfgang N.; Reindl, Markus; Weiss, Florian; Mah, Eric; Weisshaar, Nina; Madi, Alaa; Mohr, Kerstin; Schlimbach, Tilo; Cardenas, Rubi M. -H. Velasco; Koeppel, Jonas; Gruenschlaeger, Florian; Mueller, Lisann; Baumeister, Maren; Bruegger, Britta; Schmitt, Michael; Wabnitz, Guido; Samstag, Yvonne; Cui, Guoliang 分享 收藏
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