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D

David S. Shames

Genentech Inc
H指数:65
被引数:1.9万

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Non-small cell lung cancer molecular subtypes and vulnerability to immunotherapy treatment combinations

非小细胞肺癌分子亚型和免疫治疗组合的脆弱性

Nature Communications
IF15.7
2025-12-030
OAAI
Tianshi Lu; Habib Hamidi; Mark A. Socinski; Martin Reck; Federico Cappuzzo; Fabrice Barlesi; Robert M. Jotte; Sören Müller; Aditi Qamra; Assaf Amitai; Xiangnan Guan; Eloisa Fuentes; Hartmut Koeppen; Jennifer M. Giltnane; David S. Shames; Marcus Ballinger; Meng Xiao He; Yulei Wang; Minu K. Srivastava; Barzin Y. Nabet
NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING

NOTCH1通过重新激活STING逆转小细胞肺癌中的免疫抑制

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-09-162
OA
Kim, Yoo Sun; Nabet, Barzin Y.; Cortez, Briana N.; Sun, Nai-Yun; Sebastian, Robin; Redon, Christophe E.; Ray, Anagh; Liu, Liang; Ishola, Afeez A.; Loew, Sarah; Dhall, Anjali; Sindiri, Sivasish; Gayevskiy, Velimir; Lee, Min-Jung; Rastogi, Shraddha; Sato, Nahoko; Kedei, Noemi; Andresson, Thorkell; Das, Sudipto; Kumar, Suresh; Bers, Alan E.; Zhang, Hongliang; Chiappori, Alberto; Gopal, Priyanka; Abazeed, Mohamed E.; Chen, Haobin; Aladjem, Mirit I.; Pommier, Yves; Velez, Moises J.; Shames, David S.; Roper, Nitin
Digital Versus Manual PD-L1 Scoring in Advanced Non-Small Cell Lung Cancer From the IMpower110 and IMpower150 Trials

数字与人工PD-L1评分在晚期非小细胞肺癌中的应用比较：基于IMpower110和IMpower150试验

Journal of Thoracic Oncology
IF20.8
2025-08-050
PRE
Roy S. Herbst; Hen Prizant; Daniel Ruderman; Jake Conway; John Shamshoian; Hartmut Koeppen; Wei Zou; Filippo de Marinis; Giuseppe Giaccone; Jacek Jassem; David R. Spigel; Mark A. Socinski; Martin Reck; Luciana Molinero; Marcus Ballinger; David Shames; Michael Griffin; Limin Yu; Nishant Agrawal; Andrew Beck; Ilan Wapinski; Stephanie Hennek; Jennifer Giltnane; Minu K. Srivastava
Development and validation of a serum proteomic test for predicting patient outcomes in advanced non-small cell lung cancer treated with atezolizumab or docetaxel

开发并验证一种用于预测接受阿特珠单抗或多西他赛治疗的晚期非小细胞肺癌患者预后的血清蛋白质组学检测方法

JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2025-05-210
OA
Srivastava, Minu K.; Zou, Wei; McCleland, Mark; Roder, Joanna; Asmellash, Senait; Norman, Patrick; Net, Lelia; Maguire, Laura; Roder, Heinrich; Georgantas, Robert; Shames, David S.
DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

DNA损伤应答特征与广泛期小细胞肺癌的一线化疗反应及肿瘤进化途径相关。

MOLECULAR CANCER
IF33.9
2025-03-200
OA
Morris, Benjamin B.; Heeke, Simon; Xi, Yuanxin; Diao, Lixia; Wang, Qi; Rocha, Pedro; Arriola, Edurne; Lee, Myung Chang; Tyson, Darren R.; Concannon, Kyle; Ramkumar, Kavya; Stewart, C. Allison; Cardnell, Robert J.; Wang, Runsheng; Quaranta, Vito; Wang, Jing; Heymach, John V.; Nabet, Barzin Y.; Shames, David S.; Gay, Carl M.; Byers, Lauren A.
RNA-seq molecular subtypes and gene expression signatures in the phase 3 IMpower151 study of 1L bevacizumab plus pemetrexed/paclitaxel ± atezolizumab in metastatic NSCLC
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Zhou, Caicun; Sun, Charlie; Huang, Stacey; Dong, Xiaorong; Chen, Gongyan; Wang, Zhehai; Wu, Xianghua; Yao, Yu; Zhang, Yiping; Cheng, Ying; Pan, Hongming; Zhang, Xiaodong; Cui, Jiuwei; Wang, Lifeng; Chen, Xi; Li, Xiaoling; Wang, Ziping; Wang, Qiming; He, Jianxing; Wang, Mengzhao; Qian, Li; Hamidi, Habib; Li, Shanshan; Ballinger, Marcus; Shames, David S.; Srivastava, Minu
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells
Nature
IF48.5
2024-02-280
OAAI
Xiangnan Guan; Ruozhen Hu; Yoonha Choi; Shyam Srivats; Barzin Y. Nabet; John Silva; Lisa McGinnis; Robert Hendricks; Katherine Nutsch; Karl L. Banta; Ellen Duong; Alexis Dunkle; Patrick S. Chang; Chia-Jung Han; Stephanie Mittman; Nandini Molden; Pallavi Daggumati; Wendy Connolly; Melissa Johnson; Delvys Rodriguez Abreu; Byoung Chul Cho; Antoine Italiano; Ignacio Gil-Bazo; Enriqueta Felip; Ira Mellman; Sanjeev Mariathasan; David S. Shames; Raymond Meng; Eugene Y. Chiang; Robert J. Johnston; Namrata S. Patil
Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial (vol 28, 2155, 2022)
NATURE MEDICINE
IF50
2023-10-100
OAAI
Chaft, Jamie E.; Oezkan, Filiz; Kris, Mark G.; Bunn, Paul A.; Wistuba, Ignacio I.; Kwiatkowski, David J.; Owen, Dwight H.; Tang, Yan; Johnson, Bruce E.; Lee, Jay M.; Lozanski, Gerard; Pietrzak, Maciej; Seweryn, Michal; Byun, Woo Yul; Schulze, Katja; Nicholas, Alan; Johnson, Ann; Grindheim, Jessica; Hilz, Stephanie; Shames, David S.; Rivard, Chris; Toloza, Eric; Haura, Eric B.; Mcnamee, Ciaran J.; Patterson, G. Alexander; Waqar, Saiama N.; Rusch, Valerie W.; Carbone, David P.
Digital pathology based prognostic & predictive biomarkers in metastatic non-small cell lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Qamra, Aditi; Srivastava, Minu K.; Fuentes, Eloisa; Ben Trotter; Biju, Raymond; Chhor, Guillaume; Cowan, James; Gendreau, Steven; Lincoln, Webster; McGinnis, Lisa; Molinero, Luciana; Patil, Namrata S.; Schedlbauer, Amber; Schulze, Katja; Stanford-Moore, Adam; Chambre, Laura; Wapinski, Ilan; Shames, David S.; Koeppen, Hartmut; Hennek, Stephanie; Fridlyand, Jane; Giltnane, Jennifer M.; Amitai, Assaf
Anti-TIGIT antibody tiragolumab leverages myeloid cells and regulatory T cells to improve PD-L1 checkpoint blockade
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Patil, Namrata S.; Srivats, Shyam; Choi, Yoonha; Guan, Xiangnan; Nabet, Barzin; McGinnis, Lisa; Chiang, Eugene; Dunkle, Alexis; O'Gorman, Bill; Chang, Patrick S.; Hu, Ruozhen; Silva, John; Han, Joy; Au-Yeung, Amelia; Takahashi, Chikara; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Meng, Raymond; Mariathasan, Sanjeev; Johnston, Robert; Shames, David S.
A longitudinal circulating tumor DNA-based model associated with survival in metastatic non-small-cell lung cancer

基于循环肿瘤DNA的纵向模型与转移性非小细胞肺癌的生存相关

NATURE MEDICINE
IF50
2023-03-1648
OAAI
Assaf, Zoe June F.; Zou, Wei; Fine, Alexander D.; Socinski, Mark A.; Young, Amanda; Lipson, Doron; Freidin, Jonathan F.; Kennedy, Mark; Polisecki, Eliana; Nishio, Makoto; Fabrizio, David; Oxnard, Geoffrey R.; Cummings, Craig; Rode, Anja; Reck, Martin; Patil, Namrata S.; Lee, Mark; Shames, David S.; Schulze, Katja
Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial
NATURE MEDICINE
IF50
2022-09-12133
OAAI
Chaft, Jamie E.; Oezkan, Filiz; Kris, Mark G.; Bunn, Paul A.; Wistuba, Ignacio I.; Kwiatkowski, David J.; Owen, Dwight H.; Tang, Yan; Johnson, Bruce E.; Lee, Jay M.; Lozanski, Gerard; Pietrzak, Maciej; Seweryn, Michal; Byun, Woo Yul; Schulze, Katja; Nicholas, Alan; Johnson, Ann; Grindheim, Jessica; Hilz, Stephanie; Shames, David S.; Rivard, Chris; Toloza, Eric; Haura, Eric B.; McNamee, Ciaran J.; Patterson, G. Alexander; Waqar, Saiama N.; Rusch, Valerie W.; Carbone, David P.
Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial

阿特珠单抗与化疗治疗高血液肿瘤突变负荷的晚期或转移性NSCLC: BFAST队列C随机3期试验的初步分析

NATURE MEDICINE
IF50
2022-08-2263
OAAI
Peters, Solange; Dziadziuszko, Rafal; Morabito, Alessandro; Felip, Enriqueta; Gadgeel, Shirish M.; Cheema, Parneet; Cobo, Manuel; Andric, Zoran; Barrios, Carlos H.; Yamaguchi, Masafumi; Dansin, Eric; Danchaivijitr, Pongwut; Johnson, Melissa; Novello, Silvia; Mathisen, Michael S.; Shagan, Sarah M.; Schleifman, Erica; Wang, Jin; Yan, Mark; Mocci, Simonetta; Voong, David; Fabrizio, David A.; Shames, David S.; Riehl, Todd; Gandara, David R.; Mok, Tony
Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2021-08-10170
OAAI
Negrao, Marcelo, V; Skoulidis, Ferdinandos; Montesion, Meagan; Schulze, Katja; Bara, Ilze; Shen, Vincent; Xu, Hao; Hu, Sylvia; Sui, Dawen; Elamin, Yasir Y.; Le, Xiuning; Goldberg, Michael E.; Murugesan, Karthikeyan; Wu, Chang-Jiun; Zhang, Jianhua; Barreto, David S.; Robichaux, Jacqulyne P.; Reuben, Alexandre; Cascone, Tina; Gay, Carl M.; Mitchell, Kyle G.; Hong, Lingzhi; Rinsurongkawong, Waree; Roth, Jack A.; Swisher, Stephen G.; Lee, Jack; Tsao, Anne; Papadimitrakopoulou, Vassiliki; Gibbons, Don L.; Glisson, Bonnie S.; Singal, Gaurav; Miller, Vincent A.; Alexander, Brian; Frampton, Garrett; Albacker, Lee A.; Shames, David; Zhang, Jianjun; Heymach, John, V

研究方向

暂未获取到该数据
J
John D. Minna
H 指数:174论文数:2,276被引数:11.4万
A
Adi F. Gazdar
H 指数:161论文数:1,239被引数:11.5万
L
Lukas C. Amler
H 指数:53论文数:360被引数:1.3万
L
Luc Girard
H 指数:80论文数:860被引数:2.4万
I
Ignacio I. Wistuba
H 指数:153论文数:2,834被引数:10.4万
M
Mitsuo Sato
H 指数:48论文数:527被引数:1.1万
W
Wei Zou
H 指数:25论文数:100被引数:8,934
G
Garret M. Hampton
H 指数:52论文数:282被引数:1.1万
T
Tony Mok
H 指数:131论文数:1,091被引数:10.7万
N
Noriaki Sunaga
H 指数:42论文数:224被引数:5,917