Oleg Butovsky - Publications, H-index & Citations

Oleg Butovsky

Harvard University

62H指数

160论文数

3.0W被引数

收录论文 64

发表时间

Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases 溶酶体功能障碍驱动神经退行性疾病中疾病相关小胶质细胞的转录和表观遗传特征

Immunity

IF26.3

2026-08-03

PREAI

Christopher D. Balak; Johannes C.M. Schlachetzki; Addison J. Lana; Elizabeth West; Christine Hong; Jordan DuGal; Yi Zhou; Benjamin Li; Nathanael J. Spann; Payam Saisan; Vishal Sarsani; Kilian L. Kleemann; Xiaoming Zhang; Martina P. Pasillas; Sydney O’Brien; Juliette A. Bokor; Philip L.S.M. Gordts; Oleg Butovsky; Beth Stevens; Fredrik Kamme

A transcriptomic microglia taxonomy across mouse and human pathologies 跨小鼠和人类病理学的转录组小胶质细胞分类学

Nature Immunology

IF27.6

2026-03-25

OAAI

Chintan Chhatbar; Roman Sankowski; Michael Schulz; Takashi Shimizu; Marius Schwabenland; Ori Staszewski; Christian Scheiwe; Stefan Nessler; Katharina Borst; Anaelle Aurelie Dumas; Ella Trost; Daniel Berchtold; Wesley Brandão; Omar Mossad; Adrià Dalmau Gasull; Maximilian Frosch; Daniel Erny; Martin Diebold; Elena Guffart; Katharina Ternka; Mihaela Guranda; Janaki Manoja Vinnakota; Marina Friesen; Koliane Ouk; Inken Waltl; Michael LaMorte; Timothy R. Hammond; Giovanni Di Liberto; Ilena Vincenti; Mario Kreutzfeldt; Ibrahim T. Mughrabi; Yousef Al-Abed; Thomas Blank; Melanie Meyer-Luehmann; Yanick J. Crow; Nellwyn Hagen; Dimitry Ofengeim; Robert Zeiser; Matthias Kettwig; Jutta Gärtner; Andreas Meisel; Martin Schwemmle; Ulrich Kalinke; Jürgen Beck; Bertram Bengsch; Robert Thimme; Oleg Butovsky; Tamara Seredenina; Richard M. Ransohoff; Francisco J. Quintana; Katrin Kierdorf; Doron Merkler; Christine Stadelmann; Josef Priller; Marco Prinz

Immune dysfunction in Alzheimer disease 阿尔茨海默病中的免疫功能失调

Nature Reviews Neuroscience

IF26.7

2025-11-28

PREAI

Oleg Butovsky; Neta Rosenzweig; Kilian L. Kleemann; Mehdi Jorfi; Vijay K. Kuchroo; Rudolph E. Tanzi; Howard L. Weiner

Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity 辐射状胶质细胞整合素avb8调控细胞自主的小胶质细胞TGFβ1信号，该信号对于小胶质细胞表型维持是必需的。

NATURE COMMUNICATIONS

IF15.7

2025-03-22

OAAI

McKinsey, Gabriel L.; Santander, Nicolas; Zhang, Xiaoming; Kleemann, Kilian L.; Tran, Lauren; Katewa, Aditya; Conant, Kaylynn; Barraza, Matthew; Waddell, Kian; Lizama, Carlos O.; La Russa, Marie; Koo, Ji Hyun; Lee, Hyunji; Mukherjee, Dibyanti; Paidassi, Helena; Anton, E. S.; Atabai, Kamran; Sheppard, Dean; Butovsky, Oleg; Arnold, Thomas D.

Microglia in the aged brain develop a hypoactive molecular phenotype after surgery

JOURNAL OF NEUROINFLAMMATION

IF10.1

2024-12-18

OAAI

Yin, Zhuoran; Leonard, Anna K.; Porto, Carl M.; Xie, Zhongcong; Silveira, Sebastian; Culley, Deborah J.; Butovsky, Oleg; Crosby, Gregory

Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner 更正: 寡甘露酸钠改变肠道菌群，以性别特异性方式减少脑淀粉样变性和反应性小胶质细胞

MOLECULAR NEURODEGENERATION

IF17.5

2024-10-10

OAAI

Bosch, Megan E.; Dodiya, Hemraj B.; Michalkiewicz, Julia; Lee, Choonghee; Shaik, Shabana M.; Weigle, Ian Q.; Zhang, Can; Osborn, Jack; Nambiar, Aishwarya; Patel, Priyam; Parhizkar, Samira; Zhang, Xiaoqiong; Laury, Marie L.; Mondal, Prasenjit; Gomm, Ashley; Schipma, Matthew John; Mallah, Dania; Butovsky, Oleg; Chang, Eugene B.; Tanzi, Rudolph E.; Gilbert, Jack A.; Holtzman, David M.; Sisodia, Sangram S.

Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease 性别依赖的APOE4中性粒细胞-小胶质细胞相互作用驱动阿尔茨海默病的认知障碍

NATURE MEDICINE

IF50

2024-07-03

PREAI

Rosenzweig, Neta; Kleemann, Kilian L.; Rust, Thomas; Carpenter, Madison; Grucci, Madeline; Aronchik, Michael; Brouwer, Nieske; Valenbreder, Isabel; Cooper-Hohn, Joya; Iyer, Malvika; Krishnan, Rajesh K.; Sivanathan, Kisha N.; Brandao, Wesley; Yahya, Taha; Durao, Ana; Yin, Zhuoran; Chadarevian, Jean Paul; Properzi, Michael J.; Nowarski, Roni; Davtyan, Hayk; Weiner, Howard L.; Blurton-Jones, Mathew; Yang, Hyun-Sik; Eggen, Bart J. L.; Sperling, Reisa A.; Butovsky, Oleg

Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models 在阿尔茨海默病小鼠模型中，拟杆菌抑制 β-淀粉样蛋白的小胶质细胞清除并促进斑块沉积

NATURE COMMUNICATIONS

IF15.7

2024-05-08

OAAI

Wasen, Caroline; Beauchamp, Leah C.; Vincentini, Julia; Li, Shuqi; Leserve, Danielle S.; Gauthier, Christian; Lopes, Juliana R.; Moreira, Thais G.; Ekwudo, Millicent N.; Yin, Zhuoran; da Silva, Patrick; Krishnan, Rajesh K.; Butovsky, Oleg; Cox, Laura M.; Weiner, Howard L.

Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner 寡甘露酸钠改变肠道菌群，以性别特异性方式减少脑淀粉样变性和反应性小胶质细胞

MOLECULAR NEURODEGENERATION

IF17.5

2024-02-17

OAAI

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints

NATURE IMMUNOLOGY

IF27.6

2023-09-25

OAAI

Yin, Zhuoran; Rosenzweig, Neta; Kleemann, Kilian L.; Zhang, Xiaoming; Brandao, Wesley; Margeta, Milica A.; Schroeder, Caitlin; Sivanathan, Kisha N.; Silveira, Sebastian; Gauthier, Christian; Mallah, Dania; Pitts, Kristen M.; Durao, Ana; Herron, Shawn; Shorey, Hannah; Cheng, Yiran; Barry, Jen-Li; Krishnan, Rajesh K.; Wakelin, Sam; Rhee, Jared; Yung, Anthony; Aronchik, Michael; Wang, Chao; Jain, Nimansha; Bao, Xin; Gerrits, Emma; Brouwer, Nieske; Deik, Amy; Tenen, Daniel G.; Ikezu, Tsuneya; Santander, Nicolas G.; Mckinsey, Gabriel L.; Baufeld, Caroline; Sheppard, Dean; Krasemann, Susanne; Nowarski, Roni; Eggen, Bart J. L.; Clish, Clary; Tanzi, Rudolph E.; Madore, Charlotte; Arnold, Thomas D.; Holtzman, David M.; Butovsky, Oleg

Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-09-05

OAAI

Lopes, Juliana R.; Zhang, Xiaoming; Mayrink, Julia; Tatematsu, Bruna K.; Guo, Lydia; LeServe, Danielle S.; Abou-El-Hassan, Hadi; Rong, Felipe; Dalton, Maria J.; Oliveira, Marilia G.; Lanser, Toby B.; Liu, Lei; Butovsky, Oleg; Rezende, Rafael M.; Weiner, Howard L.

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2023-07-01

OAAI

Guneykaya, Dilansu; Ugursu, Bilge; Logiacco, Francesca; Popp, Oliver; Feiks, Maria Almut; Meyer, Niklas; Wendt, Stefan; Semtner, Marcus; Cherif, Fatma; Gauthier, Christian; Madore, Charlotte; Yin, Zhuoran; Cinar, Ozcan; Arslan, Taner; Gerevich, Zoltan; Mertins, Philipp; Butovsky, Oleg; Kettenmann, Helmut; Wolf, Susanne A.

Microglia states and nomenclature: A field at its crossroads 小胶质细胞状态和命名法: 十字路口的领域

NEURON

IF15

2022-11-01

718

OAAI

Paolicelli, Rosa C.; Sierra, Amanda; Stevens, Beth; Tremblay, Marie-Eve; Aguzzi, Adriano; Ajami, Bahareh; Amit, Ido; Audinat, Etienne; Bechmann, Ingo; Bennett, Mariko; Bennett, Frederick; Bessis, Alain; Biber, Knut; Bilbo, Staci; Blurton-Jones, Mathew; Boddeke, Erik; Brites, Dora; Brone, Bert; Brown, Guy C.; Butovsky, Oleg; Carson, Monica J.; Castellano, Bernardo; Colonna, Marco; Cowley, Sally A.; Cunningham, Colm; Davalos, Dimitrios; De Jager, Philip L.; de Strooper, Bart; Denes, Adam; Eggen, Bart J. L.; Eyo, Ukpong; Galea, Elena; Garel, Sonia; Ginhoux, Florent; Glass, Christopher K.; Gokce, Ozgun; Gomez-Nicola, Diego; Gonzalez, Berta; Gordon, Siamon; Graeber, Manuel B.; Greenhalgh, Andrew D.; Gressens, Pierre; Greter, Melanie; Gutmann, David H.; Haass, Christian; Heneka, Michael T.; Heppner, Frank L.; Hong, Soyon; Hume, David A.; Jung, Steffen; Kettenmann, Helmut; Kipnis, Jonathan; Koyama, Ryuta; Lemke, Greg; Lynch, Marina; Majewska, Ania; Malcangio, Marzia; Malm, Tarja; Mancuso, Renzo; Masuda, Takahiro; Matteoli, Michela; McColl, Barry W.; Miron, Veronique E.; Molofsky, Anna Victoria; Monje, Michelle; Mracsko, Eva; Nadjar, Agnes; Neher, Jonas J.; Neniskyte, Urte; Neumann, Harald; Noda, Mami; Peng, Bo; Peri, Francesca; Perry, V. Hugh; Popovich, Phillip G.; Pridans, Clare; Priller, Josef; Prinz, Marco; Ragozzino, Davide; Ransohoff, Richard M.; Salter, Michael W.; Schaefer, Anne; Schafer, Dorothy P.; Schwartz, Michal; Simons, Mikael; Smith, Cody J.; Streit, Wolfgang J.; Tuan Leng Tay; Tsai, Li-Huei; Verkhratsky, Alexei; von Bernhardi, Rommy; Wake, Hiroaki; Wittamer, Valerie; Wolf, Susanne A.; Wu, Long-Jun; Wyss-Coray, Tony

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia 调节小胶质细胞miR-155转录表型通过限制Clec7a/Galectin-3神经退行性小胶质细胞来缓解阿尔茨海默氏症诱导的视网膜血管病变

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2022-09-08

OAAI

Shi, Haoshen; Yin, Zhuoran; Koronyo, Yosef; Fuchs, Dieu-Trang; Sheyn, Julia; Davis, Miyah R.; Wilson, Jered W.; Margeta, Milica A.; Pitts, Kristen M.; Herron, Shawn; Ikezu, Seiko; Ikezu, Tsuneya; Graham, Stuart L.; Gupta, Vivek K.; Black, Keith L.; Mirzaei, Mehdi; Butovsky, Oleg; Koronyo-Hamaoui, Maya

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

IMMUNITY

IF26.3

2022-09-01

OAAI

Margeta, Milica A.; Yin, Zhuoran; Madore, Charlotte; Pitts, Kristen M.; Letcher, Sophia M.; Tang, Jing; Jiang, Shuhong; Gauthier, Christian D.; Silveira, Sebastian R.; Schroeder, Caitlin M.; Lad, Eleonora M.; Proia, Alan D.; Tanzi, Rudolph E.; Holtzman, David M.; Krasemann, Susanne; Chen, Dong Feng; Butovsky, Oleg

The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes

JOURNAL OF NEUROINFLAMMATION

IF10.1

2022-04-16

OAAI

West, Phillip K.; McCorkindale, Andrew N.; Guennewig, Boris; Ashhurst, Thomas M.; Viengkhou, Barney; Hayashida, Emina; Jung, So Ri; Butovsky, Oleg; Campbell, Iain L.; Hofer, Markus J.

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

MICROBIOME

IF12.7

2022-03-11

OAAI

Cox, Laura M.; Calcagno, Narghes; Gauthier, Christian; Madore, Charlotte; Butovsky, Oleg; Weiner, Howard L.

Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury 脊髓小胶质细胞在周围神经损伤引起的神经病理性疼痛中的性别特异性转录组

GLIA

IF5.1

2022-01-20

OAAI

Fiore, Nathan T.; Yin, Zhuoran; Guneykaya, Dilansu; Gauthier, Christian D.; Hayes, Jessica; D'Hary, Aaron; Butovsky, Oleg; Moalem-Taylor, Gila

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

NATURE COMMUNICATIONS

IF15.7

2021-08-13

OAAI

Moreira, Thais G.; Mangani, Davide; Cox, Laura M.; Leibowitz, Jeffrey; Lobo, Eduardo. L. C.; Oliveira, Mariana A.; Gauthier, Christian D.; Nakagaki, Brenda N.; Willocq, Valerie; Song, Anya; Guo, Lydia; Lima, David C. A.; Murugaiyan, Gopal; Butovsky, Oleg; Gabriely, Galina; Anderson, Ana C.; Rezende, Rafael M.; Faria, Ana Maria C.; Weiner, Howard L.

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

NEURON

IF15

2021-05-01

181

OAAI

Wang, Chao; Xiong, Monica; Gratuze, Maud; Bao, Xin; Shi, Yang; Andhey, Prabhakar Sairam; Manis, Melissa; Schroeder, Caitlin; Yin, Zhuoran; Madore, Charlotte; Butovsky, Oleg; Artyomov, Maxim; Ulrich, Jason D.; Holtzman, David M.

研究方向