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J

Joshiawa Paulk

novartis biomedical research
H指数:23
被引数:6,922

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A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

cereblon基 glue降解剂通过NEK7以依赖背景的方式调控NLRP3炎症小体

Cell Chemical Biology
IF7.2
2025-07-090
PRE
Aude Sylvain; Natacha Stoehr; Fupeng Ma; Artiom Cernijenko; Martin Schröder; Maryam Khoshouei; Melanie Vogelsanger; Michel Schoenboerner; Ashley Burke; Pasupuleti Rao; Jonathan M. Solomon; Joshiawa Paulk; Lei Xu; Janet Dawson; Damien Begue; Peggy Lefeuvre; Erik Ahrne; Andreas Hofmann; Callum J. Dickson; Philip Arabin; Alfred Zimmerlin; Michael Kiffe; Mirjam Froehlicher; Theresa Boersig; Azeddine Elhajouji; Murielle Brichet; Suchithra Menon; Shanming Liu; Matthias Mueller; Charles A. Wartchow; James Lin; Yamel Cardona Gloria; Sabine Dickhöfer; Alexander N.R. Weber; Tatjana Welzel; Jasmin Kuemmerle-Deschner; Christopher J. Farady; Robert Pulz; Frederic Bornancin; Dennis L. Buckley; Zuni I. Bassi
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction

用于胎儿血红蛋白诱导的WIZ转录因子的分子胶降解剂

Science
IF45.8
2024-01-010
PRE
Pamela Y. Ting; Sneha Borikar; John Ryan Kerrigan; Noel M. Thomsen; Eamon Aghania; Amelia E. Hinman; Alejandro Reyes; Nicolas Pizzato; Barna D. Fodor; Fabian Wu; Muluken S. Belew; Xiaohong Mao; Jian Wang; Shripad D. Chitnis; Wei Niu; Amanda Hachey; Jennifer S. Cobb; Nikolas A. Savage; Ashley A. Burke; Joshiawa Paulk; Dustin Dovala; James Anthony Lin; Matthew C. Clifton; Elizabeth Ornelas; Xiaolei Ma; Nathaniel F. Ware; Carina C. Sanchez; John A. Taraszka; Rémi Terranova; Judith Knehr; Marc Altorfer; S. Whitney Barnes; Rohan E. J. Beckwith; Jonathan M. Solomon; Natalie A. Dales; Andrew W. Patterson; J. Wagner; Tewis Bouwmeester; Glenn Dranoff; Susan C. Stevenson; James E. Bradner
Targeting oncoproteins with a positive selection assay for protein degraders

用蛋白质降解物的阳性选择试验靶向癌蛋白

SCIENCE ADVANCES
IF12.5
2021-02-0529
OAAI
Koduri, Vidyasagar; Duplaquet, Leslie; Lampson, Benjamin L.; Wang, Adam C.; Sabet, Amin H.; Ishoey, Mette; Paulk, Joshiawa; Teng, Mingxing; Harris, Isaac S.; Endress, Jennifer E.; Liu, Xiaoxi; Dasilva, Ethan; Paulo, Joao A.; Briggs, Kimberly J.; Doench, John G.; Ott, Christopher J.; Zhang, Tinghu; Donovan, Katherine A.; Fischer, Eric S.; Gygi, Steven P.; Gray, Nathanael S.; Bradner, James; Medin, Jeffrey A.; Buhrlage, Sara J.; Oser, Matthew G.; Kaelin, William G., Jr.
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex (vol 85, pg 231, 2019)
NATURE CHEMICAL BIOLOGY
IF13.7
2020-01-150
OAAI
Bussiere, Dirksen E.; Xie, Lili; Srinivas, Honnappa; Shu, Wei; Burke, Ashley; Be, Celine; Zhao, Junping; Godbole, Adarsh; King, Dan; Karki, Rajeshri G.; Hornak, Viktor; Xu, Fangmin; Cobb, Jennifer; Carte, Nathalie; Frank, Andreas O.; Frommlet, Alexandra; Graff, Patrick; Knapp, Mark; Fazal, Aleem; Okram, Barun; Jiang, Songchun; Michellys, Pierre-Yves; Beckwith, Rohan; Voshol, Hans; Wiesmann, Christian; Solomon, Jonathan M.; Paulk, Joshiawa
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
NATURE CHEMICAL BIOLOGY
IF13.7
2019-12-09165
PREAI
Bussiere, Dirksen E.; Xie, Lili; Srinivas, Honnappa; Shu, Wei; Burke, Ashley; Be, Celine; Zhao, Junping; Godbole, Adarsh; King, Dan; Karki, Rajeshri G.; Hornak, Viktor; Xu, Fangmin; Cobb, Jennifer; Carte, Nathalie; Frank, Andreas O.; Frommlet, Alexandra; Graff, Patrick; Knapp, Mark; Fazal, Aleem; Okram, Barun; Jiang, Songchun; Michellys, Pierre-Yves; Beckwith, Rohan; Voshol, Hans; Wiesmann, Christian; Solomon, Jonathan M.; Paulk, Joshiawa
The dTAG system for immediate and target-specific protein degradation

用于即时和靶标特异性蛋白质降解的dTAG系统

NATURE CHEMICAL BIOLOGY
IF13.7
2018-03-26675
OAAI
Nabet, Behnam; Roberts, Justin M.; Buckley, Dennis L.; Paulk, Joshiawa; Dastjerdi, Shiva; Yang, Annan; Leggett, Alan L.; Erb, Michael A.; Lawlor, Matthew A.; Souza, Amanda; Scott, Thomas G.; Vittori, Sarah; Perry, Jennifer A.; Qi, Jun; Winter, Georg E.; Wong, Kwok-Kin; Gray, Nathanael S.; Bradner, James E.
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

使用多激酶降解剂查询可降解Kinome的化学蛋白质组学方法

CELL CHEMICAL BIOLOGY
IF7.2
2018-01-01357
OAAI
Huang, Hai-Tsang; Dobrovolsky, Dennis; Paulk, Joshiawa; Yang, Guang; Weisberg, Ellen L.; Doctor, Zainab M.; Buckley, Dennis L.; Cho, Joong-Heui; Ko, Eunhwa; Jang, Jaebong; Shi, Kun; Choi, Hwan Geun; Griffin, James D.; Li, Ying; Treon, Steven P.; Fischer, Eric S.; Bradner, James E.; Tan, Li; Gray, Nathanael S.
MELK is not necessary for the proliferation of basal-like breast cancer cells
ELIFE
IF0
2017-09-1990
OAAI
Huang, Hai-Tsang; Seo, Hyuk-Soo; Zhang, Tinghu; Wang, Yubao; Jiang, Baishan; Li, Qing; Buckley, Dennis L.; Nabet, Behnam; Roberts, Justin M.; Paulk, Joshiawa; Dastjerdi, Shiva; Winter, Georg E.; McLauchlan, Hilary; Moran, Jennifer; Bradner, James E.; Eck, Michael J.; Dhe-Paganon, Sirano; Zhao, Jean J.; Gray, Nathanael S.
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

BET溴结构域蛋白作为独立于CDK9募集的主转录延伸因子发挥作用

MOLECULAR CELL
IF16.6
2017-07-01345
OAAI
Winter, Georg E.; Mayer, Andreas; Buckley, Dennis L.; Erb, Michael A.; Roderick, Justine E.; Vittori, Sarah; Reyes, Jaime M.; di Iulio, Julia; Souza, Amanda; Ott, Christopher J.; Roberts, Justin M.; Zeid, Rhamy; Scott, Thomas G.; Paulk, Joshiawa; Lachance, Kate; Olson, Calla M.; Dastjerdi, Shiva; Bauer, Sophie; Lin, Charles Y.; Gray, Nathanael S.; Kelliher, Michelle A.; Churchman, L. Stirling; Bradner, James E.
Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer
CANCER DISCOVERY
IF33.3
2016-08-31105
OAAI
Zhang, Haikuo; Qi, Jun; Reyes, Jaime M.; Li, Lewyn; Rao, Prakash K.; Li, Fugen; Lin, Charles Y.; Perry, Jennifer A.; Lawlor, Matthew A.; Federation, Alexander; De Raedt, Thomas; Li, Yvonne Y.; Liu, Yan; Duarte, Melissa A.; Zhang, Yanxi; Herter-Sprie, Grit S.; Kikuchi, Eiki; Carretero, Julian; Perou, Charles M.; Reibel, Jacob B.; Paulk, Joshiawa; Bronson, Roderick T.; Watanabe, Hideo; Brainson, Christine Fillmore; Kim, Carla F.; Hammerman, Peter S.; Brown, Myles; Cichowski, Karen; Long, Henry; Bradner, James E.; Wong, Kwok-Kin

研究方向

暂未获取到该数据
J
James E. Bradner
H 指数:114论文数:746被引数:5.4万
D
Dennis L. Buckley
H 指数:29论文数:67被引数:1.1万
N
Nathanael S. Gray
H 指数:145论文数:1,469被引数:8.5万
J
Jun Qi
H 指数:67论文数:852被引数:2.6万
S
Sirano Dhe‐Paganon
H 指数:61论文数:330被引数:1.4万
T
Thomas G. Scott
H 指数:16论文数:57被引数:3,326
M
Michael A. Erb
H 指数:29论文数:79被引数:4,997
G
Georg Winter
H 指数:18论文数:88被引数:3,874
H
Hyuk‐Soo Seo
H 指数:37论文数:158被引数:4,697
M
Matthew A. Lawlor
H 指数:18论文数:80被引数:3,153