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H

Hyuk-Soo Seo

Dana-Farber Cancer Institute
H指数:37
被引数:4,699

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AI-enhanced adaptive virtual screening of large libraries for ligand discovery

用于配体发现的大型文库的AI增强自适应虚拟筛选

Nature Biotechnology
IF41.7
2026-09-010
OA
Domiziana Cecchini; AkshatKumar Nigam; Ming Tang; Joana Reis; Matt Koop; Andrea Gottinger; Callum Robert Nicoll; Yao Wang; Abhilash Jayaraj; Süleyman Selim Çınaroglu˘; Ricarda Törner; Yehor Malets; Minko Gehev; Krishna M. Padmanabha Das; Kelly Churion; Jongwan Kim; Nidhin Thomas; Yong Li; Hyuk-Soo Seo; Sirano Dhe-Paganon; Christopher Secker; Mohammad Haddadnia; Alexander Hasson; Minkai Li; Abhishek Kumar; Roni Levin-Konigsberg; Eun-Bee Choi; Geoffrey I. Shapiro; Huel Cox; Luke Sebastian; Chelsea Braithwaite; Puspalata Bashyal; Dmytro S. Radchenko; Aditya Kumar; Lei Yang; Pierre-Yves Aquilanti; Henry Gabb; Amr Alhossary; Eric O’Neill; Gerhard Wagner; Alán Aspuru-Guzik; Yurii S. Moroz; Charalampos G. Kalodimos; Konstantin Fackeldey; John D. Schuetz; Andrea Mattevi; Haribabu Arthanari; Christoph Gorgulla
Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma

IRF4的药理学靶向作为多发性骨髓瘤的治疗策略

Nature Chemical Biology
IF13.7
2026-05-280
PRE
Michael P. Agius; Chen Song; Qi Liu; Tomoki Iemura; Laura Hevenor; N. Connor Payne; Romanos Sklavenitis Pistofidis; Lorena Pantano; Hongfang Zhao; Hyuk-Soo Seo; Daniel Heilpern-Mallory; Caleb Heaslip; Zhen-Yu J. Sun; Puspalata Bashyal; Michelle P. Aranha; Elizabeth Lightbody; Ralph Mazitschek; Sirano Dhe-Paganon; Constantine S. Mitsiades; Irene M. Ghobrial; Jun Qi
A druggable redox switch on SHP1 controls macrophage inflammation

一种可药物调控的SHP1氧化还原开关控制巨噬细胞炎症

Nature Chemical Biology
IF13.7
2026-03-120
PRE
Mei Ying Ng; Meredith N. Nix; Guangyan Du; Ivan Davidek; Nils Burger; Sanghee Shin; Sean Toenjes; Haruna Takeda; Megan Cheah Xin Yan; Bingsen Zhang; Haopeng Xiao; Shelley M. Wei; Hyuk-Soo Seo; Sirano Dhe-Paganon; Thomas E. Wales; John R. Engen; Evanna L. Mills; Jianwei Che; Tinghu Zhang; Nathanael S. Gray; Edward T. Chouchani
Discovery of a small molecule TLR3 agonist adjuvant

小分子TLR3激动剂佐剂的发现

Nature Communications
IF15.7
2025-12-040
OAAI
Branden Lee; Danica Dong; Etsuro Nanishi; John Mark Awad; Kimia Z. Abedi; Yoshine Saito; Francesco Borriello; Soumik Barman; Byron Brook; Aisling Kelly; Manisha Menon; Constance Marques-Mourlet; Maansi V. Gupta; Ida Lister; Chiwoo Oh; Kevin Lyskawa; Morgan Goetz; Kristina Walker; Wing Ki Cheng; Spencer E. Brightman; Pankaj Sharma; Timothy R. O’Meara; Katherine Chew; Daniel Vieira; Kevin Ryff; Cali Sweitzer; Sanya Thomas; Simon D. van Haren; Matthew Pettengill; Hyuk-Soo Seo; Sirano Dhe-Paganon; Wei Zhang; Ofer Levy; David J. Dowling
Pharmacologic interrogation of USP28 cellular function in p53 signaling

USP28细胞功能在p53信号通路中的药理学研究

Cell Chemical Biology
IF7.2
2025-09-020
PRE
Ariana S. Bratt; Susan Kilgas; Maria I. Tarazona Guzman; Robert S. Magin; Isabella Jaen Maisonet; Cara A. Starnbach; Wei Pin Teh; Anthony C. Varca; Bin Hu; Esteban Tarazona Guzman; Hyuk-Soo Seo; Sirano Dhe-Paganon; Nicholas M. Girardi; Guillaume Adelmant; Jarrod A. Marto; Dipanjan Chowdhury; Sara J. Buhrlage
Targeting transcription factors through an IMiD independent zinc finger domain

通过IMiD非依赖性锌指域靶向转录因子

EMBO MOLECULAR MEDICINE
IF8.3
2025-05-140
OA
Liu, Bee Hui; Liu, Miao; Radhakrishnan, Sridhar; Dai, Meng-Yuan; Jaladanki, Chaitanya Kumar; Gao, Chong; Tang, Jing Ping; Kumari, Kalpana; Go, Mei Lin; Vu, Kim Anh L.; Kwon, Junsu; Seo, Hyuk-Soo; Song, Kijun; Tian, Xi; Feng, Li; Tan, Justin L.; Melkonian, Arek, V; Liu, Zhaoji; Wulf, Gerburg; Arthanari, Haribabu; Qi, Jun; Dhe-Paganon, Sirano; Clohessy, John G.; Choong, Yeu Khai; Sivaraman, J.; Fan, Hao; Tenen, Daniel G.; Chai, Li
Leveraging relaxation-optimized 1H-13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins

利用弛豫优化的1H-13C相关信号在4-19F-苯丙氨酸中的原子探针作用，探究大蛋白的结构与动态特性

NATURE CHEMISTRY
IF20.2
2025-05-050
PRE
Boeszoermenyi, Andras; Radeva, Denitsa L.; Schindler, Sebastian; Valadares, Veronica; Padmanabha Das, Krishna M.; Dubey, Abhinav; Viennet, Thibault; Schmitt, Max; Kast, Peter; Gelev, Vladimir M.; Stoyanov, Nikolay; Burdzhiev, Nikola; Petrov, Ognyan; Ficarro, Scott; Marto, Jarred; Geffken, Ezekiel A.; Dhe-Paganon, Sirano; Seo, Hyuk-Soo; Alexander, Nathan D.; Cooley, Richard B.; Mehl, Ryan A.; Kovacs, Helena; Anklin, Clemens; Bermel, Wolfgang; Kuprov, Ilya; Takeuchi, Koh; Arthanari, Haribabu
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

谷胱甘肽硫转移酶通过直接激活MPST来调控线粒体功能和运动表现。

CELL METABOLISM
IF30.9
2025-02-010
PRE
Sprenger, Hans-Georg; Mittenbuhler, Melanie J.; Sun, Yizhi; Van Vranken, Jonathan G.; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A.; Smythers, Amanda L.; Vargas-Castillo, Ariana; Puszynska, Anna M.; Spinelli, Jessica B.; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L.; Gygi, Steven P.; Paulo, Joao A.; Arthanari, Haribabu; Chouchani, Edward T.; Sabatini, David M.; Spiegelman, Bruce M.
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors

开源亲电性片段筛选平台，用于识别UCHL1共价抑制剂的化学起始点

SLAS DISCOVERY
IF2.7
2024-12-010
OAAI
Ficarro, Scott B.; Marto, Zachary H.; Girardi, Nicholas M.; Deng, Dingyu; Maisonet, Isabella Jaen; Adelmant, Guillaume; Fleming, Laura E.; Sharafi, Mona; Tavares, Isidoro; Zhao, Andrew; Kim, Hyojeon; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Buhrlage, Sara J.
BAD BH3 Helices BCL-2 Mutants That Cause Venetoclax Resistance

BAD BH3螺旋BCL-2突变体导致Venetoclax耐药性

BLOOD
IF23.1
2024-11-050
PRE
Deangelo, Thomas M.; Adhikary, Utsarga; Korshavn, Kyle J.; Brotzen-Smith, Clara R.; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; Dhe-Paganon, Sirano; Wales, Thomas E.; Bird, Gregory H.; Walensky, Loren D.
BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA

BAF复杂扰动作为H3K27M小儿神经胶质瘤的新治疗机会

NEURO-ONCOLOGY
IF13.4
2023-06-120
OAAI
Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh; Hoffman, Samantha; Kugener, Guillaume; Shaw, McKenzie; Hack, Olivia; Dempster, Joshua; Lareau, Caleb; Quezada, Michael; Stanton, Ann-Catherine; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John; Root, David; Anastas, Jamie; Jones, Kristen; Conway, Amy; Stopka, Sylwia; Regan, Michael; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Mathewson, Nathan; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Nguyen, Quang-De; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G.
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a

Irisin通过其整合素受体在涉及细胞外Hsp90a的两步过程中发挥作用

MOLECULAR CELL
IF16.6
2023-06-0119
OAAI
Mu, A.; Wales, Thomas E.; Zhou, Haixia; Draga-Coleta, Sorin-Valeriu; Gorgulla, Christoph; Blackmore, Katherine A.; Mittenbuhler, Melanie J.; Kim, Caroline R.; Bogoslavski, Dina; Zhang, Qiuyang; Wang, Zi-Fu; Jedrychowski, Mark P.; Seo, Hyuk-Soo; Song, Kijun; Xu, Andrew Z.; Sebastian, Luke; Gygi, Steven P.; Arthanari, Haribabu; Dhe-Paganon, Sirano; Griffin, Patrick R.; Engen, John R.; Spiegelman, Bruce M.
Lactate regulates cell cycle by remodelling the anaphase promoting complex

乳酸通过重塑后期促进复合物来调节细胞周期

Nature
IF48.5
2023-03-150
PRE
Weihai Liu; Yun Wang; Luiz H. M. Bozi; Patrick D. Fischer; Mark P. Jedrychowski; Haopeng Xiao; Tao Wu; Narek Darabedian; Xiadi He; Evanna L. Mills; Nils Burger; Sanghee Shin; Anita Reddy; Hans-Georg Sprenger; Nhien Tran; Sally Winther; Stephen M. Hinshaw; Jingnan Shen; Hyuk-Soo Seo; Kijun Song; Andrew Z. Xu; Luke Sebastian; Jean J. Zhao; Sirano Dhe-Paganon; Jianwei Che; Steven P. Gygi; Haribabu Arthanari; Edward T. Chouchani
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice (vol 8, 18, 2023)
NPJ VACCINES
IF6.5
2023-03-030
OAAI
Nanishi, Etsuro; Borriello, Francesco; Seo, Hyuk-Soo; O'Meara, Timothy R.; McGrath, Marisa E.; Saito, Yoshine; Chen, Jing; Diray-Arce, Joann; Song, Kijun; Xu, Andrew Z.; Barman, Soumik; Menon, Manisha; Dong, Danica; Caradonna, Timothy M.; Feldman, Jared; Hauser, Blake M.; Schmidt, Aaron G.; Baden, Lindsey R.; Ernst, Robert K.; Dillen, Carly; Yu, Jingyou; Chang, Aiquan; Hilgers, Luuk; Platenburg, Peter Paul; Dhe-Paganon, Sirano; Barouch, Dan H.; Ozonoff, Al; Zanoni, Ivan; Frieman, Matthew B.; Dowling, David J.; Levy, Ofer
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

肠道微生物代谢5-ASA降低其在炎症性肠病中的临床疗效

NATURE MEDICINE
IF50
2023-02-2360
OA
Mehta, Raaj S.; Mayers, Jared R.; Zhang, Yancong; Bhosle, Amrisha; Glasser, Nathaniel R.; Nguyen, Long H.; Ma, Wenjie; Bae, Sena; Branck, Tobyn; Song, Kijun; Sebastian, Luke; Pacheco, Julian Avila; Seo, Hyuk-Soo; Clish, Clary; Dhe-Paganon, Sirano; Ananthakrishnan, Ashwin N.; Franzosa, Eric A.; Balskus, Emily P.; Chan, Andrew T.; Huttenhower, Curtis
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

用共价肌酸激酶抑制剂消耗肌酸磷酸原能量

NATURE CHEMICAL BIOLOGY
IF13.7
2023-02-2320
OA
Darabedian, Narek; Ji, Wenzhi; Fan, Mengyang; Lin, Shan; Seo, Hyuk-Soo; Vinogradova, Ekaterina V. V.; Yaron, Tomer M. M.; Mills, Evanna L. L.; Xiao, Haopeng; Senkane, Kristine; Huntsman, Emily M. M.; Johnson, Jared L. L.; Che, Jianwei; Cantley, Lewis C. C.; Cravatt, Benjamin F. F.; Dhe-Paganon, Sirano; Stegmaier, Kimberly; Zhang, Tinghu; Gray, Nathanael S. S.; Chouchani, Edward T. T.

研究方向

暂未获取到该数据
S
Sirano Dhe‐Paganon
H 指数:61论文数:330被引数:1.4万
K
Kijun Song
H 指数:12论文数:44被引数:827
N
Nathanael S. Gray
H 指数:145论文数:1,469被引数:8.5万
J
Jarrod A. Marto
H 指数:80论文数:327被引数:1.9万
S
Scott B. Ficarro
H 指数:68论文数:238被引数:1.6万
Tinghu Zhang 封面图
Tinghu Zhang
H 指数:55论文数:238被引数:1.8万
E
Ezekiel A. Geffken
H 指数:8论文数:24被引数:625
G
Günter Blobel
H 指数:128论文数:329被引数:5.5万
O
Ofer Levy
H 指数:71论文数:435被引数:2.0万
L
Luke Sebastian
H 指数:6论文数:12被引数:462