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Potent Activity of Duocarmyin- and Mmaf-Conjugated FLT3-Directed Antibody-Drug Conjugates Towards Acute Myeloid Leukemia Stem Cells in Vitro and In Vivo 杜卡米恩和MMAF偶联的FLT3靶向抗体药物偶联物对急性髓系白血病干细胞在体外的强效活性及在体内的活性 Able, Marina; Kasper, Marc-Andre; Vick, Binje; Schwach, Jonathan; Gao, Xiang; Schmitt, Saskia; Tizazu, Belay; Fischer, Amrei; Kuenzl, Sarah; Leilich, Marit; Mai, Isabelle; Ochtrop, Philipp; Stengl, Andreas; de Geus, Mark A. R.; von Bergwelt-Baildon, Michael; Schumacher, Dominik; Helma, Jonas; Goetze, Katharina S. S.; Jeremias, Irmela; Feuring, Michaela; Spiekermann, Karsten 分享 收藏
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Rational combinatorial targeting by adapter CAR-T-cells (AdCAR-T) prevents antigen escape in acute myeloid leukemia Atar, Daniel; Ruoff, Lara; Mast, Anna-Sophia; Krost, Simon; Moustafa-Oglou, Moustafa; Scheuermann, Sophia; Kristmann, Beate; Feige, Maximilian; Canak, Ayseguel; Wolsing, Kathrin; Schlager, Lennart; Schilbach, Karin; Zekri, Latifa; Ebinger, Martin; Nixdorf, Daniel; Subklewe, Marion; Schulte, Johannes; Lengerke, Claudia; Jeremias, Irmela; Werchau, Niels; Mittelstaet, Joerg; Lang, Peter; Handgretinger, Rupert; Schlegel, Patrick; Seitz, Christian M. 分享 收藏
FBXL6 is a vulnerability in AML and unmasks proteolytic cleavage as a major experimental pitfall in myeloid cells Sperk, Anna; Gabriel, Antje; Koch, Daniela; Augsburger, Abirami; Sanchez, Victoria; Brockelt, David; Oellinger, Rupert; Engleitner, Thomas; Giansanti, Piero; Ludwig, Romina; Der Maur, Priska Auf; Walter, Wencke; Haferlach, Torsten; Jeremias, Irmela; Rad, Roland; Steigenberger, Barbara; Kuster, Bernhard; Eichner, Ruth; Bassermann, Florian 分享 收藏
Editorial Expression of Concern: Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells ( Jul, 10.1038/sj.onc.1210666, 2024) Ehrhardt, H.; Haecker, S.; Wittmann, S.; Maurer, M.; Borkhardt, A.; Toloczko, A.; Debatin, K-m; Fulda, S.; Jeremias, I. 分享 收藏
SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMA Blobner, J.; Dengler, L.; Blobner, S.; Eberle, C.; Weller, J.; Teske, N.; Karschnia, P.; Ruehlmann, K.; Heinrich, K.; Ziemann, F.; Greif, P. A.; Jeremias, I.; Wuerstlein, R.; Hasselmann, K.; Dorostkar, M.; Harter, P. N.; Quach, S.; Stoecklein, V.; Albert, N. L.; Niyazi, M.; Tonn, J.; Thon, N.; Westphalen, B. C.; Baumgarten, L. 分享 收藏
Combined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo Bahrami, Ehsan; Schmid, Jan Philipp; Jurinovic, Vindi; Becker, Martin; Wirth, Anna-Katharina; Ludwig, Romina; Kreissig, Sophie; Duque Angel, Tania Vanessa; Amend, Diana; Hunt, Katharina; Oellinger, Rupert; Rad, Roland; Frenz, Joris Maximilian; Solovey, Maria; Ziemann, Frank; Mann, Matthias; Vick, Binje; Wichmann, Christian; Herold, Tobias; Jayavelu, Ashok Kumar; Jeremias, Irmela 分享 收藏
Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma Blobner, Jens; Dengler, Laura; Blobner, Sven; Eberle, Constantin; Weller, Jonathan; Teske, Nico; Karschnia, Philipp; Ruehlmann, Katharina; Heinrich, Kathrin; Ziemann, Frank; Greif, Philipp A.; Jeremias, Irmela; Wuerstlein, Rachel; Hasselmann, Korbinian; Dorostkar, Mario; Harter, Patrick N.; Quach, Stefanie; Stoecklein, Veit; Albert, Nathalie L.; Niyazi, Maximilian; Tonn, Joerg-Christian; Thon, Niklas; Westphalen, Benedikt Christoph; von Baumgarten, Louisa 分享 收藏
ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing Gopisetty, Apurva; Federico, Aniello; Surdez, Didier; Iddir, Yasmine; Zaidi, Sakina; Saint-Charles, Alexandra; Waterfall, Joshua; Saberi-Ansari, Elnaz; Wierzbinska, Justyna; Schlicker, Andreas; Mack, Norman; Schwalm, Benjamin; Previti, Christopher; Weiser, Lena; Buchhalter, Ivo; Bottcher, Anna-Lisa; Sill, Martin; Autry, Robert; Estermann, Frank; Jones, David; Volckmann, Richard; Zwijnenburg, Danny; Eggert, Angelika; Heidenreich, Olaf; Iradier, Fatima; Jeremias, Irmela; Kovar, Heinrich; Klusmann, Jan-Henning; Debatin, Klaus-Michael; Bomken, Simon; Hamerlik, Petra; Hattersley, Maureen; Witt, Olaf; Chesler, Louis; Mackay, Alan; Gojo, Johannes; Cairo, Stefano; Schueler, Julia; Schulte, Johannes; Geoerger, Birgit; Molenaar, Jan J.; Shields, David J.; Caron, Hubert N.; Vassal, Gilles; Stancato, Louis F.; Pfister, Stefan M.; Jaeger, Natalie; Koster, Jan; Kool, Marcel; Schleiermacher, Gudrun 分享 收藏
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia 单细胞转录图谱指导car-t细胞治疗急性髓系白血病的开发 Gottschlich, Adrian; Thomas, Moritz; Gruenmeier, Ruth; Lesch, Stefanie; Rohrbacher, Lisa; Igl, Veronika; Briukhovetska, Daria; Benmebarek, Mohamed-Reda; Vick, Binje; Dede, Sertac; Mueller, Katharina; Xu, Tao; Dhoqina, Dario; Maerkl, Florian; Robinson, Sophie; Sendelhofert, Andrea; Schulz, Heiko; Umut, Oeykue; Kavaka, Vladyslav; Tsiverioti, Christina Angeliki; Carlini, Emanuele; Nandi, Sayantan; Strzalkowski, Thaddaeus; Lorenzini, Theo; Stock, Sophia; Mueller, Philipp Jie; Doerr, Janina; Seifert, Matthias; Cadilha, Bruno L.; Brabenec, Ruben; Roeder, Natalie; Rataj, Felicitas; Nueesch, Manuel; Modemann, Franziska; Wellbrock, Jasmin; Fiedler, Walter; Kellner, Christian; Beltran, Eduardo; Herold, Tobias; Paquet, Dominik; Jeremias, Irmela; von Baumgarten, Louisa; Endres, Stefan; Subklewe, Marion; Marr, Carsten; Kobold, Sebastian 分享 收藏
X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL X连锁凋亡蛋白抑制剂代表了复发/难治性ALL的有希望的治疗靶点 Carlet, Michela; Schmelz, Karin; Vergalli, Jenny; Herold, Tobias; Senft, Daniela; Jurinovic, Vindi; Hoffmann, Thomas; Proba, Jutta; Weichert, Nina; Junghanss, Christian; Roth, Mareike; Eschenburg, Georg; Barz, Malwine; Henze, Guenter; Eckert, Cornelia; Eggert, Angelika; Zuber, Johannes; Hundsdoerfer, Patrick; Jeremias, Irmela 分享 收藏
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia (vol 36, pg 2396, 2022) Koschade, Sebastian E.; Klann, Kevin; Shaid, Shabnam; Vick, Binje; Stratmann, Jan A.; Tholken, Marlyn; Meyer, Laura M.; Nguyen, The Duy; Campe, Julia; Moser, Laura M.; Hock, Susanna; Baker, Fatima; Meyer, Christian T.; Wempe, Frank; Serve, Hubert; Ullrich, Evelyn; Jeremias, Irmela; Muench, Christian; Brandts, Christian H. 分享 收藏
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance Wirth, Anna-Katharina; Wange, Lucas; Vosberg, Sebastian; Henrich, Kai-Oliver; Rausch, Christian; Oezdemir, Erbey; Zeller, Christina M.; Richter, Daniel; Feuchtinger, Tobias; Kaller, Markus; Hermeking, Heiko; Greif, Philipp A.; Senft, Daniela; Jurinovic, Vindi; Bahrami, Ehsan; Jayavelu, Ashok Kumar; Westermann, Frank; Mann, Matthias; Enard, Wolfgang; Herold, Tobias; Jeremias, Irmela 分享 收藏
A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia Zhou, Fengbiao; Aroua, Nesrine; Liu, Yi; Rohde, Christian; Cheng, Jingdong; Wirth, Anna-Katharina; Fijalkowska, Daria; Goellner, Stefanie; Lotze, Michelle; Yun, Haiyang; Yu, Xiaobing; Pabst, Caroline; Sauer, Tim; Oellerich, Thomas; Serve, Hubert; Roellig, Christoph; Bornhaeuser, Martin; Thiede, Christian; Baldus, Claudia; Frye, Michaela; Raffel, Simon; Krijgsveld, Jeroen; Jeremias, Irmela; Beckmann, Roland; Trumpp, Andreas; Mueller-Tidow, Carsten 分享 收藏
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia Koschade, Sebastian E.; Klann, Kevin; Shaid, Shabnam; Vick, Binje; Stratmann, Jan A.; Thoelken, Marlyn; Meyer, Laura M.; The Duy Nguyen; Campe, Julia; Moser, Laura M.; Hock, Susanna; Baker, Fatima; Meyer, Christian T.; Wempe, Frank; Serve, Hubert; Ullrich, Evelyn; Jeremias, Irmela; Muench, Christian; Brandts, Christian H. 分享 收藏
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Prime-seq, efficient and powerful bulk RNA sequencing Janjic, Aleksandar; Wange, Lucas E.; Bagnoli, Johannes W.; Geuder, Johanna; Nguyen, Phong; Richter, Daniel; Vieth, Beate; Vick, Binje; Jeremias, Irmela; Ziegenhain, Christoph; Hellmann, Ines; Enard, Wolfgang 分享 收藏
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