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D

Donald K. Scott

diabetes obesity metabolism institute

H指数:45

被引数:6,340

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Harmine selectively enhances human beta cell identity markers and function via protein kinase A pathways

IF10.2

2026-09-210

OAAI

Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene

人胰腺α细胞异质性及轨迹推断分析揭示SMOC1为β细胞去分化基因

Nature Communications

IF15.7

2025-10-070

OAAI

SIRT2 puts the brakes on human β cell proliferation therapeutic opportunities and next challenges

SIRT2 对人类β细胞增殖的抑制作用：治疗机遇与未来挑战

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-10-010

PRE

The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia

鞘氨醇-1-磷酸受体2（S1PR2）介导慢性糖皮质激素暴露诱导的肝脂肪变性和高甘油三酯血症。

Journal of Biological Chemistry

IF3.9

2025-06-070

OA

NRF2 deficiency leads to inadequate beta cell adaptation during pregnancy and gestational diabetes

NRF2缺陷导致妊娠期间β细胞适应性不足，并引发妊娠期糖尿病。

IF11.9

2025-02-011

OAAI

NRF2 Dysregulation in Impairs Beta-Cell Mass Expansion during Pregnancy Leading to Gestational Diabetes

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2024-11-010

PRE

Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

IF7.5

2024-06-140

PRE

NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function

IF10.2

2024-01-113

OA

Transcriptional activation of the Myc gene by glucose in (3-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

MOLECULAR METABOLISM

IF6.6

2024-01-012

OAAI

Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal

IF3.3

2023-12-282

OA

Dual-Label Kinetic Assay to Monitor β-Cell Death and Proliferation

IF7.5

2023-06-200

PRE

NRF2 Regulates Neonatal β-Cell Mass Expansion

IF7.5

2023-06-200

PRE

Stabilizing 14-3-3 and ChREBP Cytoplasmic Interaction to Rescue β-Cells from Glucolipotoxicity

IF7.5

2023-06-200

PRE

Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in β-Cells

IF7.5

2023-06-200

PRE

Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

IF7.5

2023-06-200

PRE

The MODY1 gene for hepatocyte nuclear factor 4α and a feedback loop control COUP-TFII expression in pancreatic beta cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2723

OAAI

T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased (3-cell proliferation

MOLECULAR METABOLISM

IF6.6

2022-12-015

OAAI

Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure (vol 13, 4423, 2022)

NATURE COMMUNICATIONS

IF15.7

2022-09-271

OAAI

Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2022-09-1517

OAAI

Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-08-0116

OAAI