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Addressing the role of PKD3 in the T cell compartment with knockout mice Koutnik, Jiri; Neururer, Verena; Gruber, Thomas; Peer, Sebastian; Hermann-Kleiter, Natascha; Olson, William J.; Labi, Verena; Leitges, Michael; Baier, Gottfried; Siegmund, Kerstin 分享 收藏
Protein kinase CI, and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities Kenchappa, Rajappa S.; Liu, Yi; Argenziano, Michael G.; Banu, Matei A.; Mladek, Ann C.; West, Rita; Luu, Amanda; Quinones-Hinojosa, Alfredo; Hambardzumyan, Dolores; Justilien, Verline; Leitges, Michael; Sarkaria, Jann N.; Sims, Peter A.; Canoll, Peter; Murray, Nicole R.; Fields, Alan P.; Rosenfeld, Steven S. 分享 收藏
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis Brandenburg, Julius; Marwitz, Sebastian; Tazoll, Simone C.; Waldow, Franziska; Kalsdorf, Barbara; Vierbuchen, Tim; Scholzen, Thomas; Gross, Annette; Goldenbaum, Svenja; Hoelscher, Alexandra; Hein, Martina; Linnemann, Lara; Reimann, Maja; Kispert, Andreas; Leitges, Michael; Rupp, Jan; Lange, Christoph; Niemann, Stefan; Behrends, Jochen; Goldmann, Torsten; Heine, Holger; Schaible, Ulrich E.; Hoelscher, Christoph; Schwudke, Dominik; Reiling, Norbert 分享 收藏
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Protein kinase C-β-dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia 慢性淋巴细胞白血病骨髓基质细胞糖代谢蛋白激酶c-β 依赖性变化 von Heydebrand, Franziska; Fuchs, Maximilian; Kunz, Meik; Voelkl, Simon; Kremer, Anita N.; Oostendorp, Robert A. J.; Wilke, Jochen; Leitges, Michael; Egle, Alexander; Mackensen, Andreas; Lutzny-Geier, Gloria 分享 收藏
Atypical PKC controls β-secretase expression and thereby regulates production of Alzheimer plaque precursor Aβ in brain and insulin receptor degradation in liver 非典型PKC控制 β-分泌酶的表达，从而调节大脑中阿尔茨海默氏斑块前体a β 的产生和肝脏中胰岛素受体的降解 Sajan, Mini P.; Braun, Ursula; Leitges, Michael; Park, Colin; Diamond, David M.; Wu, Jin; Hansen, Barbara C.; Duncan, Mildred Acevedo; Apostolatos, Christopher A.; Apostolatos, Andre H.; Kindy, Mark; Farese, Robert V. 分享 收藏
Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance 抑制基质细胞蛋白激酶c-β 可增强b细胞恶性肿瘤的化学敏感性并克服耐药性 Park, Eugene; Chen, Jingyu; Moore, Andrew; Mangolini, Maurizio; Santoro, Antonella; Boyd, Joseph R.; Schjerven, Hilde; Ecker, Veronika; Buchner, Maike; Williamson, James C.; Lehner, Paul J.; Gasparoli, Luca; Williams, Owen; Bloehdorn, Johannes; Stilgenbauer, Stephan; Leitges, Michael; Egle, Alexander; Schmidt-Supprian, Marc; Frietze, Seth; Ringshausen, Ingo 分享 收藏
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The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling 激酶PKD3通过抑制胰岛素信号传导对胆固醇和甘油三酯合成提供负反馈 Mayer, Alexander E.; Loeffler, Mona C.; Valdes, Angel E. Loza; Schmitz, Werner; El-Merahbi, Rabih; Viera, Jonathan Trujillo; Erk, Manuela; Zhang, Thianzhou; Braun, Ursula; Heikenwalder, Mathias; Leitges, Michael; Schulze, Almut; Sumara, Grzegorz 分享 收藏
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Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis 蛋白激酶c-β 通过调节线粒体重塑，代谢重编程和血红素生物合成来决定b细胞的命运 Tsui, Carlson; Martinez-Martin, Nuria; Gaya, Mauro; Maldonado, Paula; Llorian, Miriam; Legrave, Nathalie M.; Rossi, Merja; MacRae, James I.; Cameron, Angus J.; Parker, Peter J.; Leitges, Michael; Bruckbauer, Andreas; Batista, Facundo D. 分享 收藏
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Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice (vol 11, pg 496, 2018) Parihar, S. P.; Ozturk, M.; Marakalala, M. J.; Loots, D. T.; Hurdayal, R.; Beukes, D.; Van Reenen, M.; Zak, D. E.; Mbandi, S. K.; Darboe, F.; Penn-Nicholson, A.; Hanekom, W. A.; Leitges, M.; Scriba, T. J.; Guler, R.; Brombacher, F. 分享 收藏
Atypical PKC, PKC λ/t, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease 非典型PKC，PKC λ/t，激活 β-分泌酶并增加小鼠大脑和分离的神经元细胞中的Aβ1-40/42和磷酸化tau，并且可能将高胰岛素血症和其他aPKC激活剂与阿尔茨海默氏病的病理和记忆异常的发展联系起来病 Sajan, Mini P.; Hansen, Barbara C.; Higgs, Margaret G.; Kahn, C. Ron; Braun, Ursula; Leitges, Michael; Park, Collin R.; Diamond, David M.; Farese, Robert V. 分享 收藏
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