Ohta, Atsushi; Tanada, Mikimasa; Shinohara, Shojiro; Morita, Yuya; Nakano, Kazuhiko; Yamagishi, Yusuke; Takano, Ryusuke; Kariyuki, Shiori; Iida, Takeo; Matsuo, Atsushi; Ozeki, Kazuhisa; Emura, Takashi; Sakurai, Yuuji; Takano, Koji; Higashida, Atsuko; Kojima, Miki; Muraoka, Terushige; Takeyama, Ryuuichi; Kato, Tatsuya; Kimura, Kaori; Ogawa, Kotaro; Ohara, Kazuhiro; Tanaka, Shota; Kikuchi, Yasufumi; Hisada, Nozomi; Hayashi, Ryuji; Nishimura, Yoshikazu; Nomura, Kenichi; Tachibana, Tatsuhiko; Irie, Machiko; Kawada, Hatsuo; Torizawa, Takuya; Murao, Naoaki; Kotake, Tomoya; Tanaka, Masahiko; Ishikawa, Shiho; Miyake, Taiji; Tamiya, Minoru; Arai, Masako; Chiyoda, Aya; Akai, Sho; Sase, Hitoshi; Kuramoto, Shino; Ito, Toshiya; Shiraishi, Takuya; Kojima, Tetsuo; Iikura, Hitoshi

Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations

BIODRUGS

IF6.9

2022-11-308

OAAI

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

结合pH依赖性抗原结合和新型Fc工程消除食蟹猴血浆可溶性抗原

MABS

IF7.3

2022-04-287

OAAI

Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation

PHARMACEUTICALS

IF4.8

2022-04-2213

OAAI

Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2021-09-066

OAAI

Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment

PHARMACEUTICAL RESEARCH

IF4.3

2021-05-190

PREAI

A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target (vol 23, 21, 2021)

AAPS JOURNAL

IF3.7

2021-01-200

A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target

AAPS JOURNAL

IF3.7

2021-01-073

PRE

Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation

由细胞外三磷酸腺苷激活的CD137抗体具有肿瘤选择性，在体内广泛有效，无需全身免疫激活

CANCER DISCOVERY

IF33.3

2021-01-0662

OAAI

Kamata-Sakurai, Mika; Narita, Yoshinori; Hori, Yuji; Nemoto, Takayuki; Uchikawa, Ryo; Honda, Masaki; Hironiwa, Naoka; Taniguchi, Kenji; Shida-Kawazoe, Meiri; Metsugi, Shoichi; Miyazaki, Taro; Wada, Naoko A.; Ohte, Yuki; Shimizu, Shun; Mikami, Hirofumi; Tachibana, Tatsuhiko; Ono, Natsuki; Adachi, Kenji; Sakiyama, Tetsushi; Matsushita, Tomochika; Kadono, Shojiro; Komatsu, Shun-ichiro; Sakamoto, Akihisa; Horikawa, Sayuri; Hirako, Ayano; Hamada, Koki; Naoi, Sotaro; Savory, Nasa; Satoh, Yasuko; Sato, Motohiko; Noguchi, Yuki; Shinozuka, Junko; Kuroi, Haruka; Ito, Ami; Wakabayashi, Tetsuya; Kamimura, Masaki; Isomura, Fumihisa; Tomii, Yasushi; Sawada, Noriaki; Kato, Atsuhiko; Ueda, Otoya; Nakanishi, Yoshito; Endo, Mika; Jishage, Kou-ichi; Kawabe, Yoshikii; Kitazawa, Takehisa; Igawa, Tomoyuki

Factor Villa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

THROMBOSIS AND HAEMOSTASIS

IF4.3

2017-11-28162

OAAI

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

SCIENTIFIC REPORTS

IF3.9

2017-04-24118

OAAI

Fukuzawa, Taku; Sampei, Zenjiro; Haraya, Kenta; Ruike, Yoshinao; Shida-Kawazoe, Meiri; Shimizu, Yuichiro; Gan, Siok Wan; Irie, Machiko; Tsuboi, Yoshinori; Tai, Hitoshi; Sakiyama, Tetsushi; Sakamoto, Akihisa; Ishii, Shinya; Maeda, Atsuhiko; Iwayanagi, Yuki; Shibahara, Norihito; Shibuya, Mitsuko; Nakamura, Genki; Nambu, Takeru; Hayasaka, Akira; Mimoto, Futa; Okura, Yuu; Hori, Yuji; Habu, Kiyoshi; Wada, Manabu; Miura, Takaaki; Tachibana, Tatsuhiko; Honda, Kiyofumi; Tsunoda, Hiroyuki; Kitazawa, Takehisa; Kawabe, Yoshiki; Igawa, Tomoyuki; Hattori, Kunihiro; Nezu, Junichi

Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

MABS

IF7.3

2017-04-0727

OAAI

Tatsuhiko Tachibana

个人简介

教育背景

工作经历

荣誉奖项

研究方向