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R

Regina M. Young

University of Pennsylvania
H指数:39
被引数:1.3万

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荣誉奖项

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TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
SCIENCE ADVANCES
IF12.5
2024-11-150
OAAI
Dimitri, Alexander J.; Baxter, Amy E.; Chen, Gregory M.; Hopkins, Caitlin R.; Rouin, Geoffrey T.; Huang, Hua; Kong, Weimin; Holliday, Christopher H.; Wiebking, Volker; Bartoszek, Robert; Drury, Sydney; Dalton, Katherine; Koucky, Owen M.; Chen, Zeyu; Giles, Josephine R.; Dils, Alexander T.; Jung, In-Young; O'Connor, Roddy; Collins, Sierra; Everett, John K.; Amses, Kevin; Sherrill-Mix, Scott; Chandra, Aditi; Goldman, Naomi; Vahedi, Golnaz; Jadlowsky, Julie K.; Young, Regina M.; Melenhorst, Jan Joseph; Maude, Shannon L.; Levine, Bruce L.; Frey, Noelle V.; Berger, Shelley L.; Grupp, Stephan A.; Porter, David L.; Herbst, Friederike; Porteus, Matthew H.; Carty, Shannon A.; Bushman, Frederic D.; Weber, Evan W.; Wherry, E. John; Jordan, Martha S.; Fraietta, Joseph A.
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells

抑制性共受体CTLA-4的缺失增强和激活嵌合抗原受体T细胞

IMMUNITY
IF26.3
2023-10-0149
OA
Agarwal, Sangya; Aznar, M. Angela; Rech, Andrew J.; Good, Charly R.; Kuramitsu, Shunichiro; Da, Tong; Gohil, Mercy; Chen, Linhui; Hong, Seok-Jae Albert; Ravikumar, Pranali; Rennels, Austin K.; Salas-Mckee, January; Kong, Weimin; Ruella, Marco; Davis, Megan M.; Plesa, Gabriela; Fraietta, Joseph A.; Porter, David L.; Young, Regina M.; June, Carl H.
Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells

高活性间皮素定向CAR T细胞致严重肺毒性2例

MOLECULAR THERAPY
IF12
2023-08-0125
PRE
Haas, Andrew R.; Golden, Ryan J.; Litzky, Leslie A.; Engels, Boris; Zhao, Linlin; Xu, Fangmin; Taraszka, John A.; Ramones, Melissa; Granda, Brian; Chang, Wan-Jung; Jadlowsky, Julie; Shea, Kim-Marie; Runkle, Adam; Chew, Anne; Dowd, Emily; Gonzalez, Vanessa; Chen, Fang; Liu, Xiaojun; Fang, Chongyun; Jiang, Shuguang; Davis, Megan M.; Sheppard, Neil C.; Zhao, Yangbing; Fraietta, Joseph A.; Lacey, Simon F.; Plesa, Gabriela; Melenhorst, J. Joseph; Mansfield, Keith; Brogdon, Jennifer L.; Young, Regina M.; Albelda, Steven M.; June, Carl H.; Tanyi, Janos L.
Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy

抗BCMA/CD19 CAR T细胞与多发性骨髓瘤的早期免疫调节维持对初始或后续治疗有反应

BLOOD CANCER DISCOVERY
IF11.5
2022-11-2144
OAAI
Garfall, Alfred L.; Cohen, Adam D.; Susanibar-Adaniya, Sandra P.; Hwang, Wei-Ting; Vogl, Dan T.; Waxman, Adam J.; Lacey, Simon F.; Gonzalez, Vanessa E.; Fraietta, Joseph A.; Gupta, Minnal; Kulikovskaya, Irina; Tian, Lifeng; Chen, Fang; Koterba, Natalka; Bartoszek, Robert L.; Patchin, Margaret; Xu, Rong; Plesa, Gabriela; Siegel, Don L.; Brennan, Andrea; Nelson, Anne Marie; Ferthio, Regina; Cosey, Angela; Shea, Kim-Marie; Leskowitz, Rachel; Four, Megan; Wilson, Wesley, V; Miao, Fei; Lancaster, Eric; Carreno, Beatriz M.; Linette, Gerald P.; Hexner, Elizabeth O.; Young, Regina M.; Bu, Dexiu; Mansfield, Keith G.; Brogdon, Jennifer L.; June, Carl H.; Milone, Michael C.; Stadtmauer, Edward A.
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
IMMUNITY
IF26.3
2022-03-0161
OA
Giles, Josephine R.; Manne, Sasikanth; Freilich, Elizabeth; Oldridge, Derek A.; Baxter, Amy E.; George, Sangeeth; Chen, Zeyu; Huang, Hua; Chilukuri, Lakshmi; Carberry, Mary; Giles, Lydia; Weng, Nan-Ping P.; Young, Regina M.; June, Carl H.; Schuchter, Lynn M.; Amaravadi, Ravi K.; Xu, Xiaowei; Karakousis, Giorgos C.; Mitchell, Tara C.; Huang, Alexander C.; Shi, Junwei; Wherry, E. John
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2021-08-1658
OA
Kong, Weimin; Dimitri, Alexander; Wang, Wenliang; Jung, In-Young; Ott, Christopher J.; Fasolino, Maria; Wang, Yan; Kulikovskaya, Irina; Gupta, Minnal; Yoder, Todd; DeNizio, Jamie E.; Everett, John K.; Williams, Erik F.; Xu, Jun; Scholler, John; Reich, Tyler J.; Bhoj, Vijay G.; Haines, Kathleen M.; Maus, Marcela, V; Melenhorst, J. Joseph; Young, Regina M.; Jadlowsky, Julie K.; Marcucci, Katherine T.; Bradner, James E.; Levine, Bruce L.; Porter, David L.; Bushman, Frederic D.; Kohli, Rahul M.; June, Carl H.; Davis, Megan M.; Lacey, Simon F.; Vahedi, Golnaz; Fraietta, Joseph A.
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells
NATURE MEDICINE
IF50
2021-04-22112
OA
Singh, Nathan; Frey, Noelle, V; Engels, Boris; Barrett, David M.; Shestova, Olga; Ravikumar, Pranali; Cummins, Katherine D.; Lee, Yong Gu; Pajarillo, Raymone; Chun, Inkook; Shyu, Amy; Highfill, Steven L.; Price, Andrew; Zhao, Linlin; Peng, Liaomin; Granda, Brian; Ramones, Melissa; Lu, Xueqing Maggie; Christian, David A.; Perazzelli, Jessica; Lacey, Simon F.; Roy, Nathan H.; Burkhardt, Janis K.; Colomb, Florent; Damra, Mohammad; Abdel-Mohsen, Mohamed; Liu, Ting; Liu, Dongfang; Standley, Daron M.; Young, Regina M.; Brogdon, Jennifer L.; Grupp, Stephan A.; June, Carl H.; Maude, Shannon L.; Gill, Saar; Ruella, Marco
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia (vol 24, pg 563, 2018)
NATURE MEDICINE
IF50
2021-02-0510
OAAI
Fraietta, Joseph A.; Lacey, Simon F.; Orlando, Elena J.; Pruteanu-Malinici, Iulian; Gohil, Mercy; Lundh, Stefan; Boesteanu, Alina C.; Wang, Yan; O'Connor, Roddy S.; Hwang, Wei-Ting; Pequignot, Edward; Ambrose, David E.; Zhang, Changfeng; Wilcox, Nicholas; Bedoya, Felipe; Dorfmeier, Corin; Chen, Fang; Tian, Lifeng; Parakandi, Harit; Gupta, Minnal; Young, Regina M.; Johnson, F. Brad; Kulikovskaya, Irina; Liu, Li; Xu, Jun; Kassim, Sadik H.; Davis, Megan M.; Levine, Bruce L.; Frey, Noelle V.; Siegel, Donald L.; Huang, Alexander C.; Wherry, E. John; Bitter, Hans; Brogdon, Jennifer L.; Porter, David L.; June, Carl H.; Melenhorst, J. Joseph

研究方向

暂未获取到该数据
C
Carl H. June
H 指数:177论文数:1,428被引数:14.4万
S
Simon F. Lacey
H 指数:75论文数:382被引数:3.8万
J
J. Joseph Melenhorst
H 指数:60论文数:294被引数:2.9万
B
Bruce L. Levine
H 指数:102论文数:550被引数:6.6万
J
Joseph A. Fraietta
H 指数:45论文数:359被引数:1.5万
J
John Scholler
H 指数:42论文数:212被引数:1.3万
M
Megan M. Davis
H 指数:27论文数:88被引数:7,962
I
Irina Kulikovskaya
H 指数:32论文数:124被引数:1.0万
W
Wei‐Ting Hwang
H 指数:72论文数:533被引数:2.6万
J
Jennifer L. Brogdon
H 指数:29论文数:100被引数:1.1万