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收藏分享 收藏 An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
Khalil, Bassem D.; Sanchez, Roberto; Rahman, Tasrina; Rodriguez-Tirado, Carolina; Moritsch, Stefan; Martinez, Alba Rodriguez; Miles, Brett; Farias, Eduardo; Mezei, Mihaly; Nobre, Ana Rita; Singh, Deepak; Kale, Nupura; Sproll, Karl Christoph; Sosa, Maria Soledad; Aguirre-Ghiso, Julio A. 分享 收藏 A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discoveryCrouchet, Emilie; Bandiera, Simonetta; Fujiwara, Naoto; Li, Shen; El Saghire, Hussein; Fernandez-Vaquero, Mirian; Riedl, Tobias; Sun, Xiaochen; Hirschfield, Hadassa; Juhling, Frank; Zhu, Shijia; Roehlen, Natascha; Ponsolles, Clara; Heydmann, Laura; Saviano, Antonio; Qian, Tongqi; Venkatesh, Anu; Lupberger, Joachim; Verrier, Eloi R.; Sojoodi, Mozhdeh; Oudot, Marine A.; Duong, Francois H. T.; Masia, Ricard; Wei, Lan; Thumann, Christine; Durand, Sarah C.; Gonzalez-Motos, Victor; Heide, Danijela; Hetzer, Jenny; Nakagawa, Shigeki; Ono, Atsushi; Song, Won-Min; Higashi, Takaaki; Sanchez, Roberto; Kim, Rosa S.; Bian, C. Billie; Kiani, Karun; Croonenborghs, Tom; Subramanian, Aravind; Chung, Raymond T.; Straub, Beate K.; Schuppan, Detlef; Ankavay, Maliki; Cocquerel, Laurence; Schaeffer, Evelyne; Goossens, Nicolas; Koh, Anna P.; Mahajan, Milind; Nair, Venugopalan D.; Gunasekaran, Ganesh; Schwartz, Myron E.; Bardeesy, Nabeel; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Felli, Emanuele; Pessaux, Patrick; Tanabe, Kenneth K.; Heikenwaelder, Mathias; Schuster, Catherine; Pochet, Nathalie; Zeisel, Mirjam B.; Fuchs, Bryan C.; Hoshida, Yujin; Baumert, Thomas F. 分享 收藏 Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential具有抗肿瘤潜力的cullin环E3泛素连接酶4的抑制剂Wu, Kenneth; Huynh, Khoi Q.; Lu, Iris; Moustakim, Moses; Miao, Haibin; Yu, Clinton; Haeusgen, Matthew J.; Hopkins, Benjamin D.; Huang, Lan; Zheng, Ning; Sanchez, Roberto; DeVita, Robert J.; Pan, Zhen-Qiang 分享 收藏 分享 收藏 Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate ComplexLeandro, Joao; Khamrui, Susmita; Wang, Hui; Suebsuwong, Chalada; Nemeria, Natalia S.; Huynh, Khoi; Moustakim, Moses; Secor, Cody; Wang, May; Dodatko, Tetyana; Stauffer, Brandon; Wilson, Christopher G.; Yu, Chunli; Arkin, Michelle R.; Jordan, Frank; Sanchez, Roberto; DeVita, Robert J.; Lazarus, Michael B.; Houten, Sander M. 分享 收藏 分享 收藏 DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivoLeandro, Joao; Dodatko, Tetyana; Aten, Jan; Nemeria, Natalia S.; Zhang, Xu; Jordan, Frank; Hendrickson, Ronald C.; Sanchez, Roberto; Yu, Chunli; DeVita, Robert J.; Houten, Sander M. 分享 收藏 GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regenerationAckeifi, Courtney; Wang, Peng; Karakose, Esra; Fox, Jocelyn E. Manning; Gonzalez, Bryan J.; Liu, Hongtao; Wilson, Jessica; Swartz, Ethan; Berrouet, Cecilia; Li, Yansui; Kumar, Kunal; MacDonald, Patrick E.; Sanchez, Roberto; Thorens, Bernard; DeVita, Robert; Homann, Dirk; Egli, Dieter; Scott, Donald K.; Garcia-Ocana, Adolfo; Stewart, Andrew F. 分享 收藏 Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) InhibitorKumar, Kunal; Wang, Peng; Wilson, Jessica; Zlatanic, Viktor; Berrouet, Cecilia; Khamrui, Susmita; Secor, Cody; Swartz, Ethan A.; Lazarus, Michael; Sanchez, Roberto; Stewart, Andrew F.; Garcia-Ocana, Adolfo; DeVita, Robert J. 分享 收藏 Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitorsAckeifi, Courtney; Swartz, Ethan; Kumar, Kunal; Liu, Hongtao; Chalada, Suebsuwong; Karakose, Esra; Scott, Donald K.; Garcia-Ocana, Adolfo; Sanchez, Roberto; DeVita, Robert J.; Stewart, Andrew F.; Wang, Peng 分享 收藏 分享 收藏 Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCsChang, Chan-Jung; Kotini, Andriana G.; Olszewska, Malgorzata; Georgomanoli, Maria; Teruya-Feldstein, Julie; Sperber, Henrik; Sanchez, Roberto; DeVita, Robert; Martins, Timothy J.; Abdel-Wahab, Omar; Bradley, Robert K.; Papapetrou, Eirini P. 分享 收藏 分享 收藏 In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated TauopathyZhao, Wei; Ho, Lap; Wang, Jun; Bi, Weina; Yemul, Shrishailam; Ward, Libby; Freire, Daniel; Mazzola, Paolo; Brathwaite, Justin; Mezei, Mihaly; Sanchez, Roberto; Elder, Gregory A.; Pasinetti, Giulio Maria 分享 收藏 Suramin inhibits cullin-RING E3 ubiquitin ligases苏拉明抑制cullin-ring E3泛素连接酶Wu, Kenneth; Chong, Robert A.; Yu, Qing; Bai, Jin; Spratt, Donald E.; Ching, Kevin; Lee, Chan; Miao, Haibin; Tappin, Inger; Hurwitz, Jerard; Zheng, Ning; Shaw, Gary S.; Sun, Yi; Felsenfeld, Dan P.; Sanchez, Roberto; Zheng, Jun-nian; Pan, Zhen-Qiang 分享 收藏 Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failureKho, Changwon; Lee, Ahyoung; Jeong, Dongtak; Oh, Jae Gyun; Gorski, Przemek A.; Fish, Kenneth; Sanchez, Roberto; DeVita, Robert J.; Christensen, Geir; Dahl, Russell; Hajjar, Roger J. 分享 收藏 A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication高通量化学筛选显示，harmine介导的DYRK1A抑制增加人胰腺 β 细胞复制Wang, Peng; Alvarez-Perez, Juan-Carlos; Felsenfeld, Dan P.; Liu, Hongtao; Sivendran, Sharmila; Bender, Aaron; Kumar, Anil; Sanchez, Roberto; Scott, Donald K.; Garcia-Ocana, Adolfo; Stewart, Andrew F. 分享 收藏 Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination泛素Y59-E51环在赖氨酸48聚泛素化中的关键作用Chong, Robert A.; Wu, Kenneth; Spratt, Donald E.; Yang, Yingying; Lee, Chan; Nayak, Jaladhi; Xu, Ming; Elkholi, Rana; Tappin, Inger; Li, Jessica; Hurwitz, Jerard; Brown, Brian D.; Chipuk, Jerry Edward; Chen, Zhijian J.; Sanchez, Roberto; Shaw, Gary S.; Huang, Lan; Pan, Zhen-Qiang 分享 收藏 
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