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Tobías Engel

University of Medicine and Health Sciences

49H指数
206论文数
7.4K被引数
收录论文 73
发表时间
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Purinergic Signaling: A Tribute to Francesco Di Virgilio嘌呤信号传导：致敬Francesco Di Virgilio
errNeuropharmacology
IF4.6
err2026-09-03
err0
PREAI
errPeter Illes; Pablo Pelegrin; Yong Tang; Elena Adinolfi; Tobias Engel
err分享
err收藏
Targeting the purinergic P2X7 receptor in epilepsy: Cell types matter靶向癫痫中的嘌呤能P2X7受体：细胞类型至关重要
errNeuropharmacology
IF4.6
err2026-04-15
err0
errOAAI
errTobias Engel; Valentina Salari; Meng-Juan Sun; Meghma Mitra
err分享
err收藏
Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neuronsHT22、N2A和SH-SY5Y细胞系以及原代小鼠海马神经元之间的共享和独特miRNA表达谱
errPLOS ONE
IF2.6
err2025-12-03
err0
PREAI
errMurphy, Ronan; Villegas-Salmeron, Javier; Sanz-Rodriguez, Amaya; Engel, Tobias; Mooney, Catherine; Henshall, David C.; Jimenez-Mateos, Eva M.
err分享
err收藏
Purinergic modulation of major depressive disorder: experimental findings, pathogenesis and therapeutic opportunities腺苷受体调节在重度抑郁症中的作用：实验发现、发病机制和治疗机遇
errPharmacological Research
IF10.5
err2025-10-08
err0
errOAAI
errXing-Ying Ren; Patrizia Rubini; Tobias Engel; Yong Tang; Peter Illes
err分享
err收藏
P2X7 receptor antagonism suppresses epileptiform-like activity in an inflammation-primed human iPSC-derived neuron model of drug-resistant epilepsyP2X7受体拮抗作用抑制炎症预处理的药物难治性癫痫人诱导多能干细胞来源神经元模型的癫痫样活动
errBritish Journal of Pharmacology
IF7.7
err2025-09-10
err0
errOAAI
errJaideep Kesavan; Yitao Wang; Klaus Dinkel; Michael Hamacher; Jochen H. M. Prehn; David C. Henshall; Tobias Engel
err分享
err收藏
Corrigendum to “Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice” [Brain Behav. Immun. 120 (2024) 121–140]勘误：“雄性小鼠神经元和小胶质细胞中嘌呉能P2X7受体对癫痫的相反作用” [Brain Behav. Immun. 120 (2024) 121–140]
errbrain behavior and immunity
IF0
err2025-07-26
err0
PREAI
errMariana Alves; Beatriz Gil; Javier Villegas-Salmerón; Valentina Salari; Ricardo Martins-Ferreira; Marina Arribas Blázquez; Aida Menéndez Méndez; Rogerio Da Rosa Gerbatin; Jonathon Smith; Laura de Diego-Garcia; Giorgia Conte; Juan Sierra-Marquez; Paula Merino-Serrais; Meghma Mitra; Ana Fernandez Martin; Yitao Wang; Jaideep Kesavan; Ciara Melia; Alberto Parras; Edward Beamer; Béla Zimmer; Mona Heiland; Brenton Cavanagh; Rafael Parcianello Cipolat; James Morgan; Xinchen Teng; Jochen H.M. Prehn; Paolo F. Fabene; Giuseppe Bertini; Antonio R. Artalejo; Esteban Ballestar; Annette Nicke; Luis A. Olivos-Oré; Niamh M.C. Connolly; David C. Henshall; Tobias Engel
err分享
err收藏
Neuropharmacology adenosine A2A receptor and glial glutamate transporter GLT-1 are synergistic targets to reduce brain hyperexcitability after traumatic brain injury in mice神经药理学研究表明，腺苷A2A受体和胶质细胞谷氨酸转运体GLT-1是减少小鼠创伤性脑损伤后脑过度兴奋的协同靶点。
errNeuropharmacology
IF4.6
err2025-07-23
err0
errOAAI
errMariana Alves; Rogério Gerbatin; Rebecca Kalmeijer; Denise Fedele; Tobias Engel; Detlev Boison
err分享
err收藏
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult miceCALHM1阻断剂CGP37157会增强成年小鼠癫痫持续状态期间的癫痫发作严重程度。
errPurinergic Signalling
IF2.4
err2025-07-02
err0
errOAAI
errMeghma Mitra; Amaya Sanz Rodriguez; Norman Delanty; Alan Beausang; Francesca M. Brett; Michael A. Farrell; Jane Cryan; Donncha F. O’Brien; David Henshall; Maria F. Cano-Abad; Tobias Engel
err分享
err收藏
P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in miceP2X7R拮抗作用抑制小鼠创伤性脑损伤后持续性的脑过度兴奋。
errTHERANOSTICS
IF13.3
err2025-01-27
err0
PREAI
errAlves, Mariana; de Diego-Garcia, Laura; Vegliante, Gloria; Moreno, Oscar; Gil, Beatriz; Ramos-Cabrer, Pedro; Mitra, Meghma; Martin, Ana Fernandez; Menendez-Mendez, Aida; Wang, Yitao; Strogulski, Nathan Ryzewski; Sun, Meng-Juan; Melia, Ciara; Conte, Giorgia; Plaza-Garcia, Sandra; Khalin, Igor; Teng, Xinchen; Plesnila, Nikolaus; Klebl, Bert; Dinkel, Klaus; Hamacher, Michael; Bhattachary, Anindya; Ceusters, Marc; Palmer, James; Loane, David J.; Llop, Jordi; Henshall, David C.; Engel, Tobias
err分享
err收藏
Distinct fingerprints of tRNA-derived small non-coding RNA in animal models of neurodegeneration神经变性动物模型中tRNA衍生的小非编码RNA的不同指纹图谱
errDISEASE MODELS & MECHANISMS
IF3.3
err2024-11-18
err0
errOAAI
errBaindoor, Sharada; Gibriel, Hesham A. Y.; Veno, Morten T.; Su, Junyi; Morrissey, Elena Perez; Jirstrom, Elisabeth; Woods, Ina; Kenny, Aidan; Alves, Mariana; Halang, Luise; Fabbrizio, Paola; Bilen, Maria; Engel, Tobias; Hogg, Marion C.; Bendotti, Caterina; Nardo, Giovanni; Slack, Ruth S.; Kjems, Jorgen; Prehn, Jochen H. M.
err分享
err收藏
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
errBRAIN BEHAVIOR AND IMMUNITY
IF7.6
err2024-08-01
err4
errOAAI
errAlves, Mariana; Gil, Beatriz; Villegas-Salmeron, Javier; Salari, Valentina; Martins-Ferreira, Ricardo; Blazquez, Marina Arribas; Mendez, Aida Menendez; Gerbatin, Rogerio Da Rosa; Smith, Jonathon; de Diego-Garcia, Laura; Conte, Giorgia; Sierra-Marquez, Juan; Serrais, Paula Merino; Mitra, Meghma; Martin, Ana Fernandez; Wang, Yitao; Kesavan, Jaideep; Melia, Ciara; Parras, Alberto; Beamer, Edward; Zimmer, Bela; Heiland, Mona; Cavanagh, Brenton; Cipolat, Rafael Parcianello; Morgan, James; Teng, Xinchen; Prehn, Jochen H. M.; Fabene, Paolo F.; Bertini, Giuseppe; Artalejo, Antonio R.; Ballestar, Esteban; Nicke, Annette; Olivos-Ore, Luis A.; Connolly, Niamh M. C.; Henshall, David C.; Engel, Tobias
err分享
err收藏
Immunoproteasome deficiency results in age-dependent development of epilepsy
errBRAIN COMMUNICATIONS
IF4.5
err2024-01-29
err3
errOAAI
errLeister, Hanna; Krause, Felix F.; Gil, Beatriz; Prus, Ruslan; Prus, Inna; Hellhund-Zingel, Anne; Mitra, Meghma; Gerbatin, Rogerio Da Rosa; Delanty, Norman; Beausang, Alan; Brett, Francesca M.; Farrell, Michael A.; Cryan, Jane; O'Brien, Donncha F.; Henshall, David C.; Helmprobst, Frederik; Pagenstecher, Axel; Steinhoff, Ulrich; Visekruna, Alexander; Engel, Tobias
err分享
err收藏
CPEB4-CLOCK crosstalk during temporal lobe epilepsy
errEPILEPSIA
IF6.6
err2023-08-14
err1
errOAAI
errde Diego-Garcia, Laura; Brennan, Gary P.; Auer, Theresa; Menendez-Mendez, Aida; Parras, Alberto; Martin-Gil, Alba; Mitra, Meghma; Olla, Ivana; Villalba-Benito, Leticia; Gil, Beatriz; Alves, Mariana; Lau, Kelvin; Delanty, Norman; Beausang, Alan; Cryan, Jane; Brett, Francesca M.; Farrell, Michael A.; O'Brien, Donncha F.; Mendez, Raul; Carracedo-Rodriguez, Gonzalo; Henshall, David C. C.; Lucas, Jose J.; Engel, Tobias
err分享
err收藏
MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-07-18
err12
errOAAI
errHeiland, Mona; Connolly, Niamh M. C.; Mamad, Omar; Nguyen, Ngoc T.; Kesavan, Jaideep C.; Langa, Elena; Fanning, Kevin; Sanfeliu, Albert; Yan, Yan; Su, Junyi; Veno, Morten T.; Costard, Lara S.; Neubert, Valentin; Engel, Tobias; Hill, Thomas D. M.; Freiman, Thomas M.; Mahesh, Arun; Tiwari, Vijay K.; Rosenow, Felix; Bauer, Sebastian; Kjems, Jorgen; Morris, Gareth; Henshall, David C.
err分享
err收藏
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes
errPURINERGIC SIGNALLING
IF2.4
err2023-07-15
err2
errOAAI
errKesavan, Jaideep; Watters, Orla; de Diego-Garcia, Laura; Mendez, Aida Menendez; Alves, Mariana; Dinkel, Klaus; Hamacher, Michael; Prehn, Jochen H. M.; Henshall, David C. C.; Engel, Tobias
err分享
err收藏
P2X7 receptor inhibition ameliorates ubiquitin-proteasome system dysfunction associated with Alzheimer's disease
errALZHEIMERS RESEARCH & THERAPY
IF7.6
err2023-06-07
err8
errOAAI
errBianchi, Carolina; Alvarez-Castelao, Beatriz; Sebastian-Serrano, Alvaro; Di Lauro, Caterina; Soria-Tobar, Lucia; Nicke, Annette; Engel, Tobias; Diaz-Hernandez, Miguel
err分享
err收藏
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism
errPURINERGIC SIGNALLING
IF2.4
err2023-02-16
err1
PREAI
errSmith, Jonathon; Lopez-Avila, Beatriz Gil; Engel, Tobias; Mateos, Eva M. Jimenez; Alves, Mariana
err分享
err收藏
The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2023-02-14
err15
errOAAI
errSmith, Jonathon; Mendez, Aida Menendez; Alves, Mariana; Parras, Alberto; Conte, Giorgia; Bhattacharya, Anindya; Ceusters, Marc; Nicke, Annette; Henshall, David C.; Jimenez-Mateos, Eva M.; Engel, Tobias
err分享
err收藏
Purinergic Signalling and Inflammation-Related Diseases
errCELLS
IF5.2
err2022-11-24
err5
errOAAI
errEngel, Tobias; Jimenez-Mateos, Eva Maria; Diaz-Hernandez, Miguel
err分享
err收藏
The molecular mechanisms of epilepsy and potential therapeutics
errFRONTIERS IN MOLECULAR NEUROSCIENCE
IF3.8
err2022-11-22
err2
errOAAI
errEngel, Tobias; Brennan, Gary P.; Soreq, Hermona
err分享
err收藏

研究方向

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合作学者
合作期刊
A
Andreas Strasser
H 指数: 135 · 论文数: 815
G
Gary H. Lyman
H 指数: 128 · 论文数: 948
J
Jesús Ávila
H 指数: 108 · 论文数: 854
J
Jørgen Kjems
H 指数: 100 · 论文数: 794
R
Roger P. Simon
H 指数: 88 · 论文数: 354
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