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R

Roddy S. O'Connor

University of Pennsylvania
H指数:33
被引数:1.1万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics

卵巢癌腹水中的脂质通过破坏TCR动力学来抑制T细胞活化

Nature Metabolism
IF20.8
2026-07-220
PRE
Erica G. Brown; Ewoud B. Compeer; Zhiyang Gan; Andre R. Kelly; Alexander A. Shestov; Laura Córdoba-Espejo; Mitchell T. Evans; Alan Y. Liu; Noelle H. Naughton; Tanay S. Parnaik; Jemma H. Larson; Bruce R. Blazar; Caroline R. Bartman; Joshua D. Rabinowitz; Michael L. Dustin; Daniel J. Powell; Roddy S. O’Connor
Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor costimulatory domains

通过不对称T细胞分裂诱导的命运受到嵌合抗原受体共刺激域的调节

Nature Immunology
IF27.6
2026-06-220
OAAI
Caitlin S. Frazee; Sisi Chen; Corbett T. Berry; Casey S. Lee; Reid A. Banciella; Lucianna Ngo; David Shon; Patrick J. Herman; Jake S. Fischman; Chloe L. Leff; Anna Chen; Yvonne Kuo; Alexander A. Shestov; Andre R. Kelly; Bakir Valentic; Michael C. Milone; Roddy S. O’Connor; Christoph T. Ellebrecht
Single-day non-activated IL-18-armed CAR T-cells establish a durable, stem-like state with enhanced persistence

单日未激活的IL-18武装CAR T细胞建立一种持久的、干细胞样状态并增强持久性

Blood
IF23.1
2026-04-200
PRE
Joseph S. Durgin; Shin Seo; Shadab Kazmi; Bakir Valentic; Chloe Leff; Martina Markovska; Xiaoling Jin; Feng Shen; Abdulla Berjis; Nandana Mukherjee; Ashwin Sannecy; Gabriela Plesa; Khatuna Gabunia; John Scholler; Saar I. Gill; Roddy S. O’Connor; Carl H. June; Saba Ghassemi
Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion

McDonald-Hyman C，Aguilar EG，Compeer EB，Zaiken MC，Rhee SY，Mohamed FA，等。乙酰辅酶A羧化酶1抑制通过线粒体融合增加Treg代谢并提高移植物抗宿主病治疗效率。临床研究杂志。(2025) 135:e182480。doi: 10.1172/JCI182480。

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-12-011
OA
McDonald-Hyman, Cameron; Aguilar, Ethan G.; Compeer, Ewoud B.; Zaiken, Michael C.; Rhee, Stephanie Y.; Mohamed, Fathima A.; Larson, Jemma H.; Loschi, Michael L.; Lees, Christopher; Thangavelu, Govindarajan; Sleeth, Margaret L.; Smith, Kyle D.; Whangbo, Jennifer S.; Ritz, Jerome; Sparwasser, Tim D.; O'Connor, Roddy S.; Crawford, Peter A.; Rathmell, Jeffrey C.; Kean, Leslie S.; Zeiser, Robert; Hippen, Keli L.; Dustin, Michael L.; Blazar, Bruce R.
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
SCIENCE ADVANCES
IF12.5
2024-11-150
OAAI
Dimitri, Alexander J.; Baxter, Amy E.; Chen, Gregory M.; Hopkins, Caitlin R.; Rouin, Geoffrey T.; Huang, Hua; Kong, Weimin; Holliday, Christopher H.; Wiebking, Volker; Bartoszek, Robert; Drury, Sydney; Dalton, Katherine; Koucky, Owen M.; Chen, Zeyu; Giles, Josephine R.; Dils, Alexander T.; Jung, In-Young; O'Connor, Roddy; Collins, Sierra; Everett, John K.; Amses, Kevin; Sherrill-Mix, Scott; Chandra, Aditi; Goldman, Naomi; Vahedi, Golnaz; Jadlowsky, Julie K.; Young, Regina M.; Melenhorst, Jan Joseph; Maude, Shannon L.; Levine, Bruce L.; Frey, Noelle V.; Berger, Shelley L.; Grupp, Stephan A.; Porter, David L.; Herbst, Friederike; Porteus, Matthew H.; Carty, Shannon A.; Bushman, Frederic D.; Weber, Evan W.; Wherry, E. John; Jordan, Martha S.; Fraietta, Joseph A.
Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-07-1915
PRE
Cichocki, Frank; Bin Zhang; Wu, Cheng-Ying; Chiu, Emily; Day, Abderrahman; O'Connor, Roddy S.; Yackoubov, Dima; Simantov, Ronit; McKenna, David H.; Cao, Qing; Defor, Todd E.; Janakiram, Murali; Wangen, Rose; Cayci, Zuzan; Snyder, Nathaniel; Kumar, Akhilesh; Grzywacz, Bartosz; Hwang, Justin; Geffen, Yona; Miller, Jeffrey S.; Maakaron, Joseph; Bachanova, Veronika
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors
NATURE CANCER
IF28.5
2022-05-3034
OA
Zhang, Hongru; Yu, Pengfei; Tomar, Vivek S.; Chen, Xiangjie; Atherton, Matthew J.; Lu, Zhen; Zhang, Hong-Guang; Li, Shifeng; Ortiz, Angelica; Gui, Jun; Leu, N. Adrian; Yan, Fangxue; Blanco, Andres; Meyer-Ficca, Mirella L.; Meyer, Ralph G.; Beiting, Daniel P.; Li, Jinyang; Nunez-Cruz, Selene; O'Connor, Roddy S.; Johnson, Lexus R.; Minn, Andy J.; George, Subin S.; Koumenis, Constantinos; Diehl, J. Alan; Milone, Michael C.; Zheng, Hui; Fuchs, Serge Y.

研究方向

暂未获取到该数据
M
Michael C. Milone
H 指数:57论文数:328被引数:2.3万
C
Carl H. June
H 指数:177论文数:1,428被引数:14.4万
N
Nathaniel W. Snyder
H 指数:53论文数:343被引数:1.2万
S
Saba Ghassemi
H 指数:19论文数:69被引数:5,468
M
Michael L. Dustin
H 指数:129论文数:833被引数:6.8万
J
Joseph A. Fraietta
H 指数:45论文数:359被引数:1.5万
J
John Scholler
H 指数:42论文数:212被引数:1.3万
J
Joseph S. Durgin
H 指数:11论文数:36被引数:636
B
Bruce R. Blazar
H 指数:148论文数:1,548被引数:9.0万
S
Saar Gill
H 指数:59论文数:398被引数:1.7万