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C

Christopher R. Smith

mirati therapeutics, inc.
H指数:30
被引数:4,312

个人简介

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教育背景

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工作经历

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荣誉奖项

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The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

SOS1抑制剂MRTX0902阻断KRAS激活并在依赖KRAS核苷酸负载的癌症中显示抗肿瘤活性

MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-04-194
OAAI
Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; Engstrom, Lars D.; Laguer, Jade; Calinisan, Andrew; Hebbert, Allan; Waters, Laura; Moya, Krystal; Bowcut, Vickie; Vegar, Laura; Ketcham, John M.; Ivetac, Anthony; Smith, Christopher R.; Lawson, J. David; Rahbaek, Lisa; Clarine, Jeffrey; Nguyen, Natalie; Saechao, Barbara; Parker, Cody; Elliott, Adam J.; Vanderpool, Darin; He, Leo; Hover, Laura D.; Fernandez-Banet, Julio; Coma, Silvia; Pachter, Jonathan A.; Hallin, Jill; Marx, Matthew A.; Briere, David M.; Christensen, James G.; Olson, Peter; Haling, Jacob; Khare, Shilpi
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography

通过SOS2 x射线共晶法确定的结合模式发现了五个SOS2片段命中

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-12-291
OAAI
Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, Rene; Fethiere, James; Gunn, Robin J.; Hollander, Johan; Jones, Benjamin; Ketcham, John M.; Khare, Shilpi; Kuehler, Jon; Lawson, J. David; Marx, Matthew A.; Olson, Peter; Pearson, Kelly E.; Ren, Cynthia; Tsagris, Denise; Ulaganathan, Thirumalaiselvi; Van't Veer, Inge; Wang, Xiaolun; Ivetac, Anthony
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial
NEURO-ONCOLOGY
IF13.4
2023-09-1611
OAAI
Johnson, Theodore S.; MacDonald, Tobey J.; Pacholczyk, Rafal; Aguilera, Dolly; Al-Basheer, Ahmad; Bajaj, Manish; Bandopadhayay, Pratiti; Berrong, Zuzana; Bouffet, Eric; Castellino, Robert C.; Dorris, Kathleen; Eaton, Bree R.; Esiashvili, Natia; Fangusaro, Jason R.; Foreman, Nicholas; Fridlyand, Diana; Giller, Cole; Heger, Ian M.; Huang, Chenbin; Kadom, Nadja; Kennedy, Eugene P.; Manoharan, Neevika; Martin, William; McDonough, Colleen; Parker, Rebecca S.; Ramaswamy, Vijay; Ring, Eric; Rojiani, Amyn; Sadek, Ramses F.; Satpathy, Sarthak; Schniederjan, Matthew; Smith, Amy; Smith, Christopher; Thomas, Beena E.; Vaizer, Rachel; Yeo, Kee Kiat; Bhasin, Manoj K.; Munn, David H.
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

一种有效的选择性非共价KRASG12D抑制剂的抗肿瘤功效

NATURE MEDICINE
IF50
2022-10-10207
OA
Hallin, Jill; Bowcut, Vickie; Calinisan, Andrew; Briere, David M.; Hargis, Lauren; Engstrom, Lars D.; Laguer, Jade; Medwid, James; Vanderpool, Darin; Lifset, Ella; Trinh, David; Hoffman, Natalie; Wang, Xiaolun; Lawson, J. David; Gunn, Robin J.; Smith, Christopher R.; Thomas, Nicole C.; Martinson, Matthew; Bergstrom, Alex; Sullivan, Francis; Bouhana, Karyn; Winski, Shannon; He, Leo; Fernandez-Banet, Julio; Pavlicek, Adam; Haling, Jacob R.; Rahbaek, Lisa; Marx, Matthew A.; Olson, Peter; Christensen, James G.
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-01-1876
OA
Smith, Christopher R.; Aranda, Ruth; Bobinski, Thomas P.; Briere, David M.; Burns, Aaron C.; Christensen, James G.; Clarine, Jeffery; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jean-Baptiste, Ronald; Ketcham, John M.; Kobayashi, Masakazu; Kuehler, Jon; Kulyk, Svitlana; Lawson, J. David; Moya, Krystal; Olson, Peter; Rahbaek, Lisa; Thomas, Nicole C.; Wang, Xiaolun; Waters, Laura M.; Marx, Matthew A.
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

鉴定非共价，有效和选择性的KRASG12D抑制剂MRTX1133

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-12-10354
OA
Wang, Xiaolun; Allen, Shelley; Blake, James F.; Bowcut, Vickie; Briere, David M.; Calinisan, Andrew; Dahlke, Joshua R.; Fell, Jay B.; Fischer, John P.; Gunn, Robin J.; Hallin, Jill; Laguer, Jade; Lawson, J. David; Medwid, James; Newhouse, Brad; Phong Nguyen; O'Leary, Jacob M.; Olson, Peter; Pajk, Spencer; Rahbaek, Lisa; Rodriguez, Mareli; Smith, Christopher R.; Tang, Tony P.; Thomas, Nicole C.; Vanderpool, Darin; Vigers, Guy P.; Christensen, James G.; Marx, Matthew A.
Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-2712
PREAI
Sabat, Mark; Dougan, Douglas R.; Knight, Beverly; Lawson, J. David; Scorah, Nicholas; Smith, Christopher R.; Taylor, Ewan R.; Phong Vu; Wyrick, Corey; Wang, Haixia; Balakrishna, Deepika; Hixon, Mark; Madakamutil, Loui; McConn, Donavon
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2009-12-09138
OAAI
Buchanan, Sean G.; Hendle, Jorg; Lee, Patrick S.; Smith, Christopher R.; Bounaud, Pierre-Yves; Jessen, Katti A.; Tang, Crystal M.; Huser, Nanni H.; Felce, Jeremy D.; Froning, Karen J.; Peterman, Marshall C.; Aubol, Brandon E.; Gessert, Steve F.; Sauder, Michael; Schwinn, Kenneth D.; Russell, Marijane; Rooney, Isabelle A.; Adams, Jason; Leon, Barbara C.; Do, Tuan H.; Blaney, Jeff M.; Sprengeler, Paul A.; Thompson, Devon A.; Smyth, Lydia; Pelletier, Laura A.; Atwell, Shane; Holme, Kevin; Wasserman, Stephen R.; Emtage, Spencer; Burley, Stephen K.; Reich, Siegfried H.

研究方向

暂未获取到该数据
M
Matthew A. Marx
H 指数:24论文数:159被引数:4,715
J
James G. Christensen
H 指数:86论文数:984被引数:4.6万
R
Robin J. Gunn
H 指数:12论文数:28被引数:1,763
J
J. David Lawson
H 指数:22论文数:133被引数:8,301
X
Xiaolun Wang
H 指数:16论文数:46被引数:2,049
J
John M. Ketcham
H 指数:14论文数:56被引数:1,067
P
Peter Olson
H 指数:45论文数:289被引数:1.5万
D
David M. Briere
H 指数:17论文数:193被引数:4,487
A
Anthony Ivetac
H 指数:22论文数:56被引数:2,650
L
Lars D. Engstrom
H 指数:17论文数:169被引数:4,314