Matthew A. Marx

mirati therapeutics, inc.

H指数:24

被引数:4,677

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Zirconium Hydride Catalysis Initiated by Tetrabutylammonium Fluoride

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-07-290

PRE

The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

SOS1抑制剂MRTX0902阻断KRAS激活并在依赖KRAS核苷酸负载的癌症中显示抗肿瘤活性

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-04-194

OAAI

Sudhakar, Niranjan; Yan, Larry; Qiryaqos, Fadia; Engstrom, Lars D.; Laguer, Jade; Calinisan, Andrew; Hebbert, Allan; Waters, Laura; Moya, Krystal; Bowcut, Vickie; Vegar, Laura; Ketcham, John M.; Ivetac, Anthony; Smith, Christopher R.; Lawson, J. David; Rahbaek, Lisa; Clarine, Jeffrey; Nguyen, Natalie; Saechao, Barbara; Parker, Cody; Elliott, Adam J.; Vanderpool, Darin; He, Leo; Hover, Laura D.; Fernandez-Banet, Julio; Coma, Silvia; Pachter, Jonathan A.; Hallin, Jill; Marx, Matthew A.; Briere, David M.; Christensen, James G.; Olson, Peter; Haling, Jacob; Khare, Shilpi

Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer

CANCER RESEARCH

IF16.6

2024-04-050

PRE

Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.

ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-03-133

OAAI

Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M.; Briere, David M.; Burns, Aaron C.; Haatveit, Kersti Caddell; Calinisan, Andrew; Clarine, Jeffery; Elliott, Adam; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jones, Benjamin; Kuehler, Jon; Lawson, J. David; Nguyen, Natalie; Parker, Cody; Pearson, Kelly E.; Rahbaek, Lisa; Saechao, Barbara; Wang, Xiaolun; Waters, Anna; Waters, Laura; Watkins, Ashlee H.; Olson, Peter; Smith, Christopher R.; Christensen, James G.; Marx, Matthew A.

Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-02-292

OAAI

Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography

通过SOS2 x射线共晶法确定的结合模式发现了五个SOS2片段命中

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-12-291

OAAI

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2023-10-251

OAAI

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

一种有效的选择性非共价KRASG12D抑制剂的抗肿瘤功效

NATURE MEDICINE

IF50

2022-10-10207

Hallin, Jill; Bowcut, Vickie; Calinisan, Andrew; Briere, David M.; Hargis, Lauren; Engstrom, Lars D.; Laguer, Jade; Medwid, James; Vanderpool, Darin; Lifset, Ella; Trinh, David; Hoffman, Natalie; Wang, Xiaolun; Lawson, J. David; Gunn, Robin J.; Smith, Christopher R.; Thomas, Nicole C.; Martinson, Matthew; Bergstrom, Alex; Sullivan, Francis; Bouhana, Karyn; Winski, Shannon; He, Leo; Fernandez-Banet, Julio; Pavlicek, Adam; Haling, Jacob R.; Rahbaek, Lisa; Marx, Matthew A.; Olson, Peter; Christensen, James G.

Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy

ACS OMEGA

IF4.3

2022-08-314

OAAI

Design and Discovery of MRTX0902, a Potent, Selective, Brain- Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction

MRTX0902的设计和发现，SOS1:KRAS蛋白-蛋白相互作用的有效，选择性，脑渗透性和口服生物利用度抑制剂

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-07-1450

OAAI

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-01-1876

Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits

RSC MEDICINAL CHEMISTRY

IF3.6

2022-01-014

OAAI

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

鉴定非共价，有效和选择性的KRASG12D抑制剂MRTX1133

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-10354

MRTX1719: A first-in-class MTA-cooperative PRMT5 inhibitor that selectively elicits antitumor activity in MTAP/CDKN2A deleted cancer models

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-12-012

PRE

The anti-tumor activity of the KRAS G12C inhibitor MRTX849 is augmented by cetuximab in CRC tumor models

CANCER RESEARCH

IF16.6

2020-08-151

PRE

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

鉴定临床开发候选药物MRTX849，一种用于治疗癌症的共价KRASG12C抑制剂

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-04-06370

OAAI

Fell, Jay B.; Fischer, John P.; Baer, Brian R.; Blake, James F.; Bouhana, Karyn; Briere, David M.; Brown, Karin D.; Burgess, Laurence E.; Burns, Aaron C.; Burkard, Michael R.; Chiang, Harrah; Chicarelli, Mark J.; Cook, Adam W.; Gaudino, John J.; Hallin, Jill; Hanson, Lauren; Hartley, Dylan P.; Hicken, Erik J.; Hingorani, Gary P.; Hinklin, Ronald J.; Mejia, Macedonio J.; Olson, Peter; Otten, Jennifer N.; Rhodes, Susan P.; Rodriguez, Martha E.; Savechenkov, Pavel; Smith, Darin J.; Sudhakar, Niranjan; Sullivan, Francis X.; Tang, Tony P.; Vigers, Guy P.; Wollenberg, Lance; Christensen, James G.; Marx, Matthew A.

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

KRASG12C抑制剂MRTX849为小鼠模型和患者中KRAS突变癌症的治疗易感性提供了见解

CANCER DISCOVERY

IF33.3

2020-01-09702

OAAI

Hallin, Jill; Engstrom, Lars D.; Hargis, Lauren; Calinisan, Andrew; Aranda, Ruth; Briere, David M.; Sudhakar, Niranjan; Bowcut, Vickie; Baer, Brian R.; Ballard, Joshua A.; Burkard, Michael R.; Fell, Jay B.; Fischer, John P.; Vigers, Guy P.; Xue, Yaohua; Gatto, Sole; Fernandez-Banet, Julio; Pavlicek, Adam; Velastagui, Karen; Chao, Richard C.; Barton, Jeremy; Pierobon, Mariaelena; Baldelli, Elisa; Patricoin, Emanuel F., III; Cassidy, Douglas P.; Marx, Matthew A.; Rybkin, Igor I.; Johnson, Melissa L.; Ou, Sai-Hong Ignatius; Lito, Piro; Papadopoulos, Kyriakos P.; Janne, Pasi A.; Olson, Peter; Christensen, James G.

Insight towards therapeutic susceptibility of KRAS mutant cancers from MRTX1257, a novel KRAS G12C mutant selective small molecule inhibitor

CANCER RESEARCH

IF16.6

2019-07-017

PRE

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

发现四氢吡啶并嘧啶作为具有体内活性的KRAS-G12C的不可逆共价抑制剂

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-11-0799

OAAI

Fell, Jay B.; Fischer, John P.; Baer, Brian R.; Ballard, Joshua; Blake, James F.; Bouhana, Karyn; Brandhuber, Barbara J.; Briere, David M.; Burgess, Laurence E.; Burkard, Michael R.; Chiang, Harrah; Chicarelli, Mark J.; Davidson, Kevin; Gaudino, John J.; Hallin, Jill; Hanson, Lauren; Hee, Kenneth; Hicken, Erik J.; Hinklin, Ronald J.; Marx, Matthew A.; Mejia, Macedonio J.; Olson, Peter; Savechenkov, Pavel; Sudhakar, Niranjan; Tang, Tony P.; Vigers, Guy P.; Zecca, Henry; Christensen, James G.

Matthew A. Marx

个人简介

教育背景

工作经历

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