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R

Robin J. Gunn

mirati therapeutics, inc.
H指数:12
被引数:1,760

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer
CANCER RESEARCH
IF16.6
2024-04-050
PRE
Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-133
OAAI
Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M.; Briere, David M.; Burns, Aaron C.; Haatveit, Kersti Caddell; Calinisan, Andrew; Clarine, Jeffery; Elliott, Adam; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jones, Benjamin; Kuehler, Jon; Lawson, J. David; Nguyen, Natalie; Parker, Cody; Pearson, Kelly E.; Rahbaek, Lisa; Saechao, Barbara; Wang, Xiaolun; Waters, Anna; Waters, Laura; Watkins, Ashlee H.; Olson, Peter; Smith, Christopher R.; Christensen, James G.; Marx, Matthew A.
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography

通过SOS2 x射线共晶法确定的结合模式发现了五个SOS2片段命中

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-12-291
OAAI
Smith, Christopher R.; Chen, Dan; Christensen, James G.; Coulombe, Rene; Fethiere, James; Gunn, Robin J.; Hollander, Johan; Jones, Benjamin; Ketcham, John M.; Khare, Shilpi; Kuehler, Jon; Lawson, J. David; Marx, Matthew A.; Olson, Peter; Pearson, Kelly E.; Ren, Cynthia; Tsagris, Denise; Ulaganathan, Thirumalaiselvi; Van't Veer, Inge; Wang, Xiaolun; Ivetac, Anthony
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

一种有效的选择性非共价KRASG12D抑制剂的抗肿瘤功效

NATURE MEDICINE
IF50
2022-10-10207
OA
Hallin, Jill; Bowcut, Vickie; Calinisan, Andrew; Briere, David M.; Hargis, Lauren; Engstrom, Lars D.; Laguer, Jade; Medwid, James; Vanderpool, Darin; Lifset, Ella; Trinh, David; Hoffman, Natalie; Wang, Xiaolun; Lawson, J. David; Gunn, Robin J.; Smith, Christopher R.; Thomas, Nicole C.; Martinson, Matthew; Bergstrom, Alex; Sullivan, Francis; Bouhana, Karyn; Winski, Shannon; He, Leo; Fernandez-Banet, Julio; Pavlicek, Adam; Haling, Jacob R.; Rahbaek, Lisa; Marx, Matthew A.; Olson, Peter; Christensen, James G.
Design and Discovery of MRTX0902, a Potent, Selective, Brain- Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction

MRTX0902的设计和发现，SOS1:KRAS蛋白-蛋白相互作用的有效，选择性，脑渗透性和口服生物利用度抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-07-1450
OAAI
Ketcham, John M.; Haling, Jacob; Khare, Shilpi; Bowcut, Vickie; Briere, David M.; Burns, Aaron C.; Gunn, Robin J.; Ivetac, Anthony; Kuehler, Jon; Kulyk, Svitlana; Laguer, Jade; Lawson, J. David; Moya, Krystal; Nguyen, Natalie; Rahbaek, Lisa; Saechao, Barbara; Smith, Christopher R.; Sudhakar, Niranjan; Thomas, Nicole C.; Vegar, Laura; Vanderpool, Darin; Wang, Xiaolun; Yan, Larry; Olson, Peter; Christensen, James G.; Marx, Matthew A.
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-01-1876
OA
Smith, Christopher R.; Aranda, Ruth; Bobinski, Thomas P.; Briere, David M.; Burns, Aaron C.; Christensen, James G.; Clarine, Jeffery; Engstrom, Lars D.; Gunn, Robin J.; Ivetac, Anthony; Jean-Baptiste, Ronald; Ketcham, John M.; Kobayashi, Masakazu; Kuehler, Jon; Kulyk, Svitlana; Lawson, J. David; Moya, Krystal; Olson, Peter; Rahbaek, Lisa; Thomas, Nicole C.; Wang, Xiaolun; Waters, Laura M.; Marx, Matthew A.
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

鉴定非共价，有效和选择性的KRASG12D抑制剂MRTX1133

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-12-10354
OA
Wang, Xiaolun; Allen, Shelley; Blake, James F.; Bowcut, Vickie; Briere, David M.; Calinisan, Andrew; Dahlke, Joshua R.; Fell, Jay B.; Fischer, John P.; Gunn, Robin J.; Hallin, Jill; Laguer, Jade; Lawson, J. David; Medwid, James; Newhouse, Brad; Phong Nguyen; O'Leary, Jacob M.; Olson, Peter; Pajk, Spencer; Rahbaek, Lisa; Rodriguez, Mareli; Smith, Christopher R.; Tang, Tony P.; Thomas, Nicole C.; Vanderpool, Darin; Vigers, Guy P.; Christensen, James G.; Marx, Matthew A.

研究方向

暂未获取到该数据
J
James G. Christensen
H 指数:86论文数:984被引数:4.6万
X
Xiaolun Wang
H 指数:16论文数:46被引数:2,046
M
Matthew A. Marx
H 指数:24论文数:159被引数:4,712
C
Christopher R. Smith
H 指数:30论文数:182被引数:4,309
J
John M. Ketcham
H 指数:14论文数:56被引数:1,066
J
J. David Lawson
H 指数:22论文数:133被引数:8,298
D
David M. Briere
H 指数:17论文数:193被引数:4,484
A
Anthony Ivetac
H 指数:22论文数:56被引数:2,649
P
Peter Olson
H 指数:45论文数:289被引数:1.5万
J
Jon Kuehler
H 指数:8论文数:19被引数:408