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李

李大力 (Dali Li)

east china normal university

60H指数
273论文数
1.1W被引数
收录论文 147
发表时间
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Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2利用Tracking-seq2对CRISPR-Cas脱靶效应进行超灵敏分析
errNature Communications
IF15.7
err2026-08-11
err0
errOAAI
errTingting Cong; Runda Xu; Xuancheng Chen; Junsong Yuan; Zuomiao Lin; Wenqin Yang; Anji Ju; Liren Wang; Qingcan Wang; Jiqin Zhang; Yinqing Li; Dali Li; Ming Zhu
err分享
err收藏
High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing通过同时编辑腺嘌呤、胞嘧啶和鸟嘌呤实现高多样性碱基诱变
errNature Communications
IF15.7
err2026-07-27
err0
errOAAI
errMengjia Hong; Changming Luan; Meng Yuan; Hao Huang; Xinyuan Guo; Dihao Meng; Molin Huang; Ye Xu; Shanghui Zhao; Ke Chen; Jiao Chen; Dali Li; Liang Chen
err分享
err收藏
Precise DNA base editing using AlphaFold3-based contact modelling基于AlphaFold3接触建模的精确DNA碱基编辑
errNature
IF48.5
err2026-07-22
err0
PREAI
errHaowei Meng; Zhixin Lei; Yongchang Yan; Liren Wang; Sihan Zhang; Xichen Rao; Chuyun Shao; Xiaoting Zhang; Ke Chen; Lei Yang; Rongrong Liu; Gaohui Yang; Ruoyu Shen; Ruichu Gu; Xinyan Wang; Yiya Wang; Suiru Lu; Zhicong Lv; Bo He; Han Wen; Dali Li; Chengqi Yi
err分享
err收藏
Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain作者更正：通过融合单链DNA结合蛋白结构域提高胞嘧啶碱基编辑器的效率和靶向范围
errNature Cell Biology
IF19.1
err2026-06-17
err0
PREAI
errXiaohui Zhang; Liang Chen; Biyun Zhu; Liren Wang; Caiyu Chen; Mengjia Hong; Yifan Huang; Huiying Li; Honghui Han; Bailian Cai; Weishi Yu; Shuming Yin; Lei Yang; Zuozhen Yang; Meizhen Liu; Ying Zhang; Zhiyong Mao; Yuxuan Wu; Mingyao Liu; Dali Li
err分享
err收藏
Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid母体肥胖通过20-羟基花生四烯酸驱动的通路诱导雄性后代肾脏中巨噬细胞向肌成纤维细胞的转化
errNature Communications
IF15.7
err2026-05-14
err0
errOAAI
errFengbo Zhong; Xingyu Huang; Huiru Sun; Mengxuan Wang; Qi Qi; Xinlin Song; Kai Lin; Zhuozhuo Li; Jiayun Shen; Qiuyu Lu; Miaomiao Li; Jiaqi Zhang; Ling Yuan; Jia Lv; Xin Wang; Yiyun Cheng; Qihui Wu; Shaohua Fan; Shougang Zhuang; Jia Rao; Dali Li; Yuting Guan
err分享
err收藏
Chidamide synergizes with cisplatin-etoposide to trigger pyroptosis and anti-tumor immunity in diffuse large B-cell lymphomaChidamide与顺铂-依托泊苷协同作用，在弥漫性大B细胞淋巴瘤中触发焦亡和抗肿瘤免疫
errCommunications Medicine
IF6.3
err2026-04-21
err0
errOAAI
errJianbo Wu; Yingying Ye; Danyang Ran; Xing Wang; Hanwen Zhu; Hanmei Zhang; Fuqing Meng; Yalong Song; Zhiwei Li; Lan Mi; Xiaoyuan Zhang; Yixin Qian; Hanrong Li; Xiaowei Tong; Peihuang Wu; Bowen Sun; Xinya Li; Weimin Zhang; Dali Li; Huajun Wu; Yingjie Yu; Yunkun Dang; Fan Lai; Lijuan Deng; Yuqin Song; Jun Zhu; Yan Xie; Mi Deng
err分享
err收藏
Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope工程化改造的Un1Cas12f1用于具有增强活性和靶向范围的多元基因组编辑
errNature Communications
IF15.7
err2026-02-19
err0
errOAAI
errYanan Huo; Jiale Mei; Dan Zhang; Bing Yan; Dexin Zhang; Chao Dong; Shuming Yin; Meizhen Liu; Xinyan Wang; Dan Chen; Yuting Guan; Gaojie Song; Bing Du; Yongming Wang; Zongli Zheng; Hong Liu; Dali Li; Lei Yang; Liren Wang
err分享
err收藏
A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers一种泛KRAS抑制剂及其衍生的降解剂在KRAS驱动的癌症中表现出多方面的抗肿瘤效果
errCancer Cell
IF44.5
err2025-08-07
err0
errOAAI
errJuanjuan Feng; Xuanzheng Xiao; Xinting Xia; Jian Min; Weiying Tang; Xinyi Shi; Ke Xu; Guizhen Zhou; Kangkang Li; Panpan Shen; Rujuan Bao; Shuyao Wu; Mengjia Lin; Kun Yuan; Zhengke Lian; Longmiao Hu; Na Li; Zhengzhen Wu; Xiaotong Zhai; Xiaogu Liu; Kewen Hu; Jun Wu; Chunyong Ding; Huixin Zhao; Xinqi Gong; Sulin Zhang; Jianping Jin; Dali Li; Mingyao Liu; Youqiong Ye; Buyong Ma; Rey-Ting Guo; Ao Zhang; Xiufeng Pang
err分享
err收藏
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseasesPPDPF通过调节NMNAT活性在慢性肾脏疾病中维持近端小管的完整性。
errSCIENCE ADVANCES
IF12.5
err2025-03-21
err0
errOAAI
errFang, Xiaoliang; Zhong, Yi; Zheng, Rui; Wu, Qihui; Liu, Yu; Zhang, Dexin; Wang, Yuwei; Ding, Wubing; Wang, Kaiyuan; Zhong, Fengbo; Lin, Kai; Yao, Xiaohui; Hu, Qingxun; Li, Xiaofei; Xu, Guofeng; Liu, Na; Nie, Jing; Li, Dali
err分享
err收藏
BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exerciseBMAL1/PGC1a4-FNDC5/irisin轴影响不同时间点抗阻运动的结果。
errJOURNAL OF SPORT AND HEALTH SCIENCE
IF10.3
err2025-02-28
err2
errOAAI
errMingwei Guo; Fei Shen; Xiaozhen Guo; Jun Zhang; Ying Ma; Xia Wu; Hui Zuo; Jing Yao; Yepeng Hu; Dongmei Wang; Yu Li; Jin Li; Jin Qiu; Jian Yu; Meiyao Meng; Ying Zheng; Xin Chen; Mingkai Gong; Kailin Liu; Ling Jin; Xiangyu Ren; Qiang Zhang; Yu Zhao; Xuejiang Gu; Feixia Shen; Dali Li; Liangcai Gao; Chang Liu; Fei Zhou; Mian Li; Jiqiu Wang; Shuzhe Ding; Xinran Ma; Jian Lu; Cen Xie; Junjie Xiao; Lingyan Xu
err分享
err收藏
Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model通过碱基编辑改善苯丙酮尿症PahR408W小鼠模型的代谢和行为缺陷
errMOLECULAR THERAPY
IF12
err2025-01-01
err1
PREAI
errYin, Shuming; Gao, Liangcai; Sun, Xiaoyue; Zhang, Mei; Gao, Hongyi; Chen, Xiaoqing; Zhang, Dan; Ming, Xinyu; Yang, Lei; Hu, Yaqiang; Chen, Xi; Liu, Meizhen; Zhan, Xia; Guan, Yuting; Wang, Liren; Han, Lianshu; Zhu, Ping; Li, Dali
err分享
err收藏
Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9
errINTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
IF3.9
err2024-08-16
err0
errOAAI
errZhang, Chen; Nie, Yongqiang; Xu, Bufang; Mu, Chunlan; Tian, Geng G.; Li, Xiaoyong; Cheng, Weiwei; Zhang, Aijun; Li, Dali; Wu, Ji
err分享
err收藏
Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos
errMOLECULAR CELL
IF16.6
err2024-08-01
err2
PREAI
errXue, Niannian; Hong, Dishan; Zhang, Dan; Wang, Qian; Zhang, Shun; Yang, Lei; Chen, Xi; Li, Yongmei; Han, Honghui; Hu, Chunyi; Liu, Mingyao; Song, Gaojie; Guan, Yuting; Wang, Liren; Zhu, Yifan; Li, Dali
err分享
err收藏
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases用于治疗遗传性肝病的患者来源的肝细胞的有效扩增和CRISPR-Cas9-mediated基因校正
errCELL STEM CELL
IF20.4
err2024-08-01
err2
errOAAI
errZhang, Kun; Wan, Ping; Wang, Liren; Wang, Zhen; Tan, Fangzhi; Li, Jie; Ma, Xiaolong; Cen, Jin; Yuan, Xiang; Liu, Yang; Sun, Zhen; Cheng, Xi; Liu, Yuanhua; Liu, Xuhao; Hu, Jiazhi; Zhong, Guisheng; Li, Dali; Xia, Qiang; Hui, Lijian
err分享
err收藏
Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy
errCIRCULATION
IF38.6
err2024-07-23
err2
errOAAI
errYang, Ping; Lou, Yingmei; Geng, Zilong; Guo, Zhizhao; Wu, Shuo; Li, Yige; Song, Kaiyuan; Shi, Ting; Zhang, Shasha; Xiong, Junhao; Chen, Alex F.; Li, Dali; Pu, William T.; Da, Lintai; Zhang, Yan; Sun, Kun; Zhang, Bing
err分享
err收藏
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing (vol 41, pg 663, 2023)
errNATURE BIOTECHNOLOGY
IF41.7
err2024-04-24
err0
PREAI
errChen, Liang; Zhu, Biyun; Ru, Gaomeng; Meng, Haowei; Yan, Yongchang; Hong, Mengjia; Zhang, Dan; Luan, Changming; Zhang, Shun; Wu, Hao; Gao, Hongyi; Bai, Sijia; Li, Changqing; Ding, Ruoyi; Xue, Niannian; Lei, Zhixin; Chen, Yuting; Guan, Yuting; Siwko, Stefan; Cheng, Yiyun; Song, Gaojie; Wang, Liren; Yi, Chengqi; Liu, Mingyao; Li, Dali
err分享
err收藏
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos (vol 42, pg pages638, 2024)
errNATURE BIOTECHNOLOGY
IF41.7
err2024-04-24
err0
PREAI
errChen, Liang; Hong, Mengjia; Luan, Changming; Gao, Hongyi; Ru, Gaomeng; Guo, Xinyuan; Zhang, Dujuan; Zhang, Shun; Li, Changwei; Wu, Jun; Randolph, Peyton B.; Sousa, Alexander A.; Qu, Chao; Zhu, Yifan; Guan, Yuting; Wang, Liren; Liu, Mingyao; Feng, Bo; Song, Gaojie; Liu, David R.; Li, Dali
err分享
err收藏
Author Correction: Engineering a precise adenine base editor with minimal bystander editing(vol 19, pg 101, 2024)
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-04-22
err0
errOAAI
errChen, Liang; Zhang, Shun; Xue, Niannian; Hong, Mengjia; Zhang, Xiaohui; Zhang, Dan; Yang, Jing; Bai, Sijia; Huang, Yifan; Meng, Haowei; Wu, Hao; Luan, Changming; Zhu, Biyun; Ru, Gaomeng; Gao, Hongyi; Zhong, Liping; Liu, Meizhen; Liu, Mingyao; Cheng, Yiyun; Yi, Chengqi; Wang, Liren; Zhao, Yongxiang; Song, Gaojie; Li, Dali
err分享
err收藏
Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders
errSCIENCE ADVANCES
IF12.5
err2024-04-19
err7
errOAAI
errTan, Echuan; Wan, Tao; Pan, Qi; Duan, Jianan; Zhang, Song; Wang, Ruijue; Gao, Peng; Lv, Jia; Wang, Hui; Li, Dali; Ping, Yuan; Cheng, Yiyun
err分享
err收藏
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-03-29
err4
PREAI
errYang, Lei; Huo, Yanan; Wang, Man; Zhang, Dan; Zhang, Tianai; Wu, Hao; Rao, Xichen; Meng, Haowei; Yin, Shuming; Mei, Jiale; Zhang, Dexin; Chen, Xi; Lv, Jia; Liu, Meizhen; Cheng, Yiyun; Guan, Yuting; Feng, Bo; Song, Gaojie; Yi, Chengqi; Liu, Mingyao; Zeng, Fanyi; Wang, Liren; Li, Dali
err分享
err收藏

研究方向

基因治疗整合型载体非整合型载体会随时间而丢失，长期疗效无法保证基因编辑技术遗传疾病动物模型建立农业育种基因编辑技术体系优化与创新基因治疗策略开发与可行性研究微生物产品药物研发遗传改造
合作学者
合作期刊
S
Stanley Nattel
H 指数: 149 · 论文数: 1.0K
D
David R. Liu
H 指数: 124 · 论文数: 379
M
Mary K. Estes
H 指数: 123 · 论文数: 688
张晓红 封面图
张晓红 (Xiaohong Zhang)
H 指数: 119 · 论文数: 1.9K
S
Siew C. Ng
H 指数: 111 · 论文数: 809
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