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D

David Xu

indiana university bloomington

H指数:16

被引数:1,324

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Structure-aware dual-target drug design through collaborative learning of pharmacophore combination and molecular simulation

CHEMICAL SCIENCE

IF7.4

2024-01-010

OAAI

Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation

共价片段筛选鉴定Rgl2 RalGEF半胱氨酸用于靶向共价抑制Ral gtp酶激活

IF3.4

2022-02-097

OA

Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR•uPA Interaction

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-12-105

OA

Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection

IF3.4

2020-12-0310

PREAI

Biomarker Development for Metastatic Renal Cell Carcinoma: Omics, Antigens, T-cells, and Beyond

JOURNAL OF PERSONALIZED MEDICINE

IF3

2020-11-137

OAAI

Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

ACS CHEMICAL BIOLOGY

IF3.8

2020-04-034

OAAI

Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-03-1637

OAAI

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD•Yap Protein-Protein Interaction

CELL CHEMICAL BIOLOGY

IF7.2

2019-03-01152

OAAI

Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries

IF3.4

2018-12-206

OAAI

Small molecules inhibit ex vivo tumor growth in bone

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-12-013

OAAI

Small-molecule CaVα1•CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-10-2423

OAAI

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition (vol 24, pg 968, 2018)

NATURE MEDICINE

IF50

2018-08-093

OAAI

Wong, Gabrielle S.; Zhou, Jin; Liu, Jie Bin; Wu, Zhong; Xu, Xinsen; Li, Tianxia; Xu, David; Schumacher, Steven E.; Puschhof, Jens; McFarland, James; Zou, Charles; Dulak, Austin; Henderson, Les; Xu, Peng; O'Day, Emily; Rendak, Rachel; Liao, Wei-li; Cecchi, Fabiola; Hembrough, Todd; Schwartz, Sarit; Szeto, Christopher; Rustgi, Anil K.; Wong, Kwok-Kin; Diehl, J. Alan; Jensen, Karin; Graziano, Francesco; Ruzzo, Annamaria; Fereshetian, Shaunt; Mertins, Philipp; Carr, Steven A.; Beroukhim, Rameen; Nakamura, Kenichi; Oki, Eiji; Watanabe, Masayuki; Baba, Hideo; Imamura, Yu; Catenacci, Daniel; Bass, Adam J.

Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma

CANCER DISCOVERY

IF33.3

2018-05-3196

OAAI

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

NATURE MEDICINE

IF50

2018-05-28219

OAAI

Wong, Gabrielle S.; Zhou, Jin; Liu, Jie Bin; Wu, Zhong; Xu, Xinsen; Li, Tianxia; Xu, David; Schumacher, Steven E.; Puschhof, Jens; McFarland, James; Zou, Charles; Dulak, Austin; Henderson, Les; Xu, Peng; O'Day, Emily; Rendak, Rachel; Liao, Wei-li; Cecchi, Fabiola; Hembrough, Todd; Schwartz, Sarit; Szeto, Christopher; Rustgi, Anil K.; Wong, Kwok-Kin; Diehl, J. Alan; Jensen, Karin; Graziano, Francesco; Ruzzo, Annamaria; Fereshetian, Shaunt; Mertins, Philipp; Carr, Steven A.; Beroukhim, Rameen; Nakamura, Kenichi; Oki, Eiji; Watanabe, Masayuki; Baba, Hideo; Imamura, Yu; Catenacci, Daniel; Bass, Adam J.

Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists

模拟小分子拮抗剂紧密蛋白-蛋白复合物的分子间相互作用

IF3.4

2017-10-2314

OAAI

A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2017-08-2917

OAAI

Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2017-06-0112

OAAI

Structure-Based Target-Specific Screening Leads to Small-Molecule CaMKII Inhibitors

IF3.4

2017-04-1810

OAAI

Effect of Binding Pose and Modeled Structures on SVMGen and GlideScore Enrichment of Chemical Libraries

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2016-05-2416

OAAI

RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-01-1381

OA