Khuchtumur Bum-Erdene

Department of Veterans Affairs

H指数:15

被引数:904

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Degradation of the TEAD·YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules That Bind to the TEAD Allosteric Lipid Pocket

TEAD·YAP/TAZ转录因子复合物的降解：靶向TEAD别构脂质口袋的异双功能小分子

ACS Chemical Biology

IF3.8

2026-04-080

PRE

Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

通过酪氨酸共价键形成的小分子KRAS抑制剂

CHEMMEDCHEM

IF3.4

2025-05-260

PRE

Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation

CHEMMEDCHEM

IF3.4

2023-07-061

Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD•YAP1 interaction

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-013

PRE

Small-Molecule Cyanamide Pan-TEADmiddotYAP1 Covalent Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-2312

PRE

Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia

新型选择性Galectin-3拮抗剂对急性淋巴细胞白血病具有细胞毒性

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-04-1510

PRE

Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation

共价片段筛选鉴定Rgl2 RalGEF半胱氨酸用于靶向共价抑制Ral gtp酶激活

CHEMMEDCHEM

IF3.4

2022-02-097

Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR•uPA Interaction

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-12-105

Small-Molecule Inhibition of the uPAR uPA Interaction by Conformational Selection

CHEMMEDCHEM

IF3.4

2020-12-0310

PREAI

Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

ACS CHEMICAL BIOLOGY

IF3.8

2020-04-034

OAAI

Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-03-1637

OAAI

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD•Yap Protein-Protein Interaction

CELL CHEMICAL BIOLOGY

IF7.2

2019-03-01152

OAAI

Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries

CHEMMEDCHEM

IF3.4

2018-12-206

OAAI

Small molecules inhibit ex vivo tumor growth in bone

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-12-013

OAAI

Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists

模拟小分子拮抗剂紧密蛋白-蛋白复合物的分子间相互作用

CHEMMEDCHEM

IF3.4

2017-10-2314

OAAI

Galectin-1 inhibitors and their potential therapeutic applications: a patent review

EXPERT OPINION ON THERAPEUTIC PATENTS

IF4.6

2016-03-2573

PREAI

Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3′-sulfo-lactose, and 2′-fucosyllactose

SCIENTIFIC REPORTS

IF3.9

2016-02-0137

OAAI

Structural characterization of human galectin-4 C-terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens

FEBS JOURNAL

IF4.2

2015-07-1439

OAAI

Galectin-3 inhibitors: a patent review (2008-present)

EXPERT OPINION ON THERAPEUTIC PATENTS

IF4.6

2014-08-09103

PREAI

Targeting Multiple Conformations Leads to Small Molecule Inhibitors of the uPAR.uPA Protein-Protein Interaction That Block Cancer Cell Invasion

ACS CHEMICAL BIOLOGY

IF3.8

2011-09-2955

OAAI

Khuchtumur Bum-Erdene

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