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D

Debattama R. Sen

Harvard University
H指数:21
被引数:7,132

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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

体内CRISPR筛选鉴定多发性骨髓瘤中CAR T细胞功能修饰因子

Nature
IF48.5
2025-09-240
PRE
Nelson H. Knudsen; Giulia Escobar; Felix Korell; Tamina Kienka; Celeste Nobrega; Seth Anderson; Andrew Y. Cheng; Maria Zschummel; Alexander Armstrong; Amanda Bouffard; Michael C. Kann; Sadie Goncalves; Hans W. Pope; Mitra Pezeshki; Alexander Rojas; Juliette S. M. T. Suermondt; Merle Phillips; Trisha R. Berger; Sangwoo Park; Diego Salas-Benito; Elijah P. Darnell; Filippo Birocchi; Mark B. Leick; Rebecca C. Larson; John G. Doench; Debattama Sen; Kathleen B. Yates; Robert T. Manguso; Marcela V. Maus
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

通过靶向CD38克服人类肿瘤移植组织对免疫治疗的抵抗

Cell Reports Medicine
IF10.6
2025-06-270
OAAI
Or-Yam Revach; Angelina M. Cicerchia; Ofir Shorer; Claire A. Palin; Boryana Petrova; Seth Anderson; Baolin Liu; Joshua Park; Lee Chen; Arnav Mehta; Samuel J. Wright; Niamh McNamee; Aya Tal-Mason; Giulia Cattaneo; Payal Tiwari; Hongyan Xie; Johanna M. Sweere; Li-Chun Cheng; Natalia Sigal; Elizabeth Enrico; Marisa Miljkovic; Shane A. Evans; Ngan Nguyen; Mark E. Whidden; Ramji Srinivasan; Matthew H. Spitzer; Yi Sun; Tatyana Sharova; Aleigha R. Lawless; William A. Michaud; Martin Q. Rasmussen; Jacy Fang; Jeannette R. Brook; Feng Chen; Xinhui Wang; Cristina R. Ferrone; Donald P. Lawrence; Ryan J. Sullivan; David Liu; Uma M. Sachdeva; Debattama R. Sen; Keith T. Flaherty; Robert T. Manguso; Lloyd Bod; Manolis Kellis; Genevieve M. Boland; Keren Yizhak; Jiekun Yang; Naama Kanarek; Moshe Sade-Feldman; Nir Hacohen; Russell W. Jenkins
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
NATURE IMMUNOLOGY
IF27.6
2024-09-170
PRE
Weiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.
The aged tumor microenvironment limits T cell control of cancer

老年肿瘤微环境限制了T细胞对癌症的控制

NATURE IMMUNOLOGY
IF27.6
2024-05-145
OA
Chen, Alex C. Y.; Jaiswal, Sneha; Martinez, Daniela; Yerinde, Cansu; Ji, Keely; Miranda, Velita; Fung, Megan E.; Weiss, Sarah A.; Zschummel, Maria; Taguchi, Kazuhiro; Garris, Christopher S.; Mempel, Thorsten R.; Hacohen, Nir; Sen, Debattama R.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

PTPN2/PTPN1抑制剂ABBV-CLS-484释放有效的抗肿瘤免疫力

Nature
IF48.5
2023-10-040
OAAI
Christina K. Baumgartner; Hakimeh Ebrahimi-Nik; Arvin Iracheta-Vellve; Keith M. Hamel; Kira E. Olander; Thomas G. R. Davis; Kathleen A. McGuire; Geoff T. Halvorsen; Omar I. Avila; Chirag H. Patel; Sarah Y. Kim; Ashwin V. Kammula; Audrey J. Muscato; Kyle Halliwill; Prasanthi Geda; Kelly L. Klinge; Zhaoming Xiong; Ryan Duggan; Liang Mu; Mitchell D. Yeary; James C. Patti; Tyler M. Balon; Rebecca Mathew; Carey Backus; Domenick E. Kennedy; Angeline Chen; Kenton Longenecker; Joseph T. Klahn; Cara L. Hrusch; Navasona Krishnan; Charles W. Hutchins; Jax P. Dunning; Marinka Bulic; Payal Tiwari; Kayla J. Colvin; Cun Lan Chuong; Ian C. Kohnle; Matthew G. Rees; Andrew Boghossian; Melissa Ronan; Jennifer A. Roth; Meng-Ju Wu; Juliette S. M. T. Suermondt; Nelson H. Knudsen; Collins K. Cheruiyot; Debattama R. Sen; Gabriel K. Griffin; Todd R. Golub; Nabeel El-Bardeesy; Joshua H. Decker; Yi Yang; Magali Guffroy; Stacey Fossey; Patricia Trusk; Im-Meng Sun; Yue Liu; Wei Qiu; Qi Sun; Marcia N. Paddock; Elliot P. Farney; Mark A. Matulenko; Clay Beauregard; Jennifer M. Frost; Kathleen B. Yates; Philip R. Kym; Robert T. Manguso
Targeting TBK1 to overcome resistance to cancer immunotherapy

靶向TBK1以克服对癌症免疫疗法的耐药性

Nature
IF48.5
2023-01-120
PRE
Yi Sun; Or-yam Revach; Seth Anderson; Emily A. Kessler; Clara H. Wolfe; Anne Jenney; Caitlin E. Mills; Emily J. Robitschek; Thomas G. R. Davis; Sarah Kim; Amina Fu; Xiang Ma; Jia Gwee; Payal Tiwari; Peter P. Du; Princy Sindurakar; Jun Tian; Arnav Mehta; Alexis M. Schneider; Keren Yizhak; Moshe Sade-Feldman; Thomas LaSalle; Tatyana Sharova; Hongyan Xie; Shuming Liu; William A. Michaud; Rodrigo Saad-Beretta; Kathleen B. Yates; Arvin Iracheta-Vellve; Johan K. E. Spetz; Xingping Qin; Kristopher A. Sarosiek; Gao Zhang; Jong Wook Kim; Mack Y. Su; Angelina M. Cicerchia; Martin Q. Rasmussen; Samuel J. Klempner; Dejan Juric; Sara I. Pai; David M. Miller; Anita Giobbie-Hurder; Jonathan H. Chen; Karin Pelka; Dennie T. Frederick; Susanna Stinson; Elena Ivanova; Amir R. Aref; Cloud P. Paweletz; David A. Barbie; Debattama R. Sen; David E. Fisher; Ryan B. Corcoran; Nir Hacohen; Peter K. Sorger; Keith T. Flaherty; Genevieve M. Boland; Robert T. Manguso; Russell W. Jenkins
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
NATURE IMMUNOLOGY
IF27.6
2021-07-2667
OAAI
Tonnerre, Pierre; Wolski, David; Subudhi, Sonu; Al-Jabban, Jihad; Hoogeveen, Ruben C.; Damasio, Marcos; Drescher, Hannah K.; Bartsch, Lea M.; Tully, Damien C.; Sen, Debattama R.; Bean, David J.; Brown, Joelle; Torres-Cornejo, Almudena; Robidoux, Maxwell; Kvistad, Daniel; Alatrakchi, Nadia; Cui, Ang; Lieb, David; Cheney, James A.; Gustafson, Jenna; Lewis-Ximenez, Lia L.; Massenet-Regad, Lucile; Eisenhaure, Thomas; Aneja, Jasneet; Haining, W. Nicholas; Chung, Raymond T.; Hacohen, Nir; Allen, Todd M.; Kim, Arthur Y.; Lauer, Georg M.
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade

双侧肿瘤模型确定与患者对免疫检查点阻断反应相关的转录程序

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-09-0931
OAAI
Chen, Ivy X.; Newcomer, Kathleen; Pauken, Kristen E.; Juneja, Vikram R.; Naxerova, Kamila; Wu, Michelle W.; Pinter, Matthias; Sen, Debattama R.; Singer, Meromit; Sharpe, Arlene H.; Jain, Rakesh K.
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

成纤维细胞网状细胞通过表观遗传重塑增强T细胞代谢和存活

NATURE IMMUNOLOGY
IF27.6
2019-10-2161
OAAI
Brown, Flavian D.; Sen, Debattama R.; LaFleur, Martin W.; Godec, Jernej; Lukacs-Kornek, Veronika; Schildberg, Frank A.; Kim, Hye-Jung; Yates, Kathleen B.; Ricoult, Stephane J. H.; Bi, Kevin; Trombley, Justin D.; Kapoor, Varun N.; Stanley, Illana A.; Cremasco, Viviana; Danial, Nika N.; Manning, Brendan D.; Sharpe, Arlene H.; Haining, W. Nicholas; Turley, Shannon J.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade (vol 20, pg 326, 2019)
NATURE IMMUNOLOGY
IF27.6
2019-10-0313
OAAI
Miller, Brian C.; Sen, Debattama R.; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V.; LaFleur, Martin W.; Yates, Kathleen B.; Lako, Ana; Felt, Kristen; Naik, Girish S.; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R.; Ishizuka, Jeffrey J.; Collier, Jenna L.; Griffin, Gabriel K.; Maleri, Seth; Comstock, Dawn E.; Weiss, Sarah A.; Brown, Flavian D.; Panda, Arpit; Zimmer, Margaret D.; Manguso, Robert T.; Hodi, F. Stephen; Rodig, Scott J.; Sharpe, Arlene H.; Haining, W. Nicholas

研究方向

暂未获取到该数据
A
Arlene H. Sharpe
H 指数:154论文数:744被引数:10.9万
K
Kathleen B. Yates
H 指数:26论文数:81被引数:8,082
W
W. Nicholas Haining
H 指数:54论文数:193被引数:2.6万
R
Robert T. Manguso
H 指数:23论文数:105被引数:6,859
B
Brian C. Miller
H 指数:22论文数:100被引数:8,125
R
Rose Al Abosy
H 指数:6论文数:16被引数:2,677
M
Martin W. LaFleur
H 指数:22论文数:104被引数:8,518
S
Sarah A. Weiss
H 指数:17论文数:82被引数:4,723
S
Scott J. Rodig
H 指数:129论文数:1,502被引数:7.7万
N
Nir Hacohen
H 指数:123论文数:626被引数:10.0万