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B

Brian C. Miller

broad institute of mit and harvard
H指数:22
被引数:8,169

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CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

CRISPR筛选识别恢复癌症中年龄相关T细胞功能障碍的靶点

Cell
IF42.5
2026-07-290
PRE
Alex C.Y. Chen; Keely Y. Ji; Cansu Yerinde; Nelson H. Knudsen; Kevin Bi; Shumeng Hao; Vasyl Zhabotynsky; Daniela Martinez; Thomas J. Carmona-LaSalle; Kazuhiro Taguchi; Katherine H. Xu; Elizabeth M. Seider; Marc A. Schwartz; Maria Zschummel; Linda T. Nieman; Kathleen B. Yates; Francesca S. Gazzaniga; Brian C. Miller; Thorsten R. Mempel; Robert T. Manguso
Structure-guided design and engineering of a biparatopic antibody targeting CCR2 in triple negative breast cancer

基于结构的C型化学趋化因子受体2（CCR2）靶向双旁特异抗体在 triple negative breast cancer 中的设计与工程化

Journal of Controlled Release
IF11.5
2025-10-150
OAAI
Timothy S. Little; Yuyan Wang; Ameya P. Chaudhari; Omar M. Budayr; Jessica G. Tetterton-Kellner; Alex Bastian; Adam D. Brown; Natalie E. Jasiewicz; Amelia McCue; Henry S. Earp; Brian C. Miller; Juliane Nguyen
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4

肿瘤内缺氧通过慢性激活整合应激反应转录因子ATF4促进CD8+ T细胞功能障碍

Immunity
IF26.3
2025-09-250
OAAI
Coral del Mar Alicea Pauneto; Brian P. Riesenberg; Evelyn J. Gandy; Andrew S. Kennedy; Genevieve T. Clutton; Jessica W. Hem; Katie E. Hurst; Elizabeth G. Hunt; Jarred M. Green; Brian C. Miller; Steven P. Angus; Gary L. Johnson; Robert J. Esther; Jennifer L. Guerriero; Peng Gao; David R. Soto-Pantoja; Robert L. Ferris; Jennifer L. Modliszewski; Michael F. Coleman; H. Kay Chung; J. Justin Milner; Stergios J. Moschos; R. Luke Wiseman; Jessica E. Thaxton
Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201)

给予雄激素受体途径抑制剂的转移性去势抵抗性前列腺癌患者的克隆造血和临床结局 (联盟A031201)

CLINICAL CANCER RESEARCH
IF10.2
2024-09-180
PRE
Jensen, Jeffrey L.; Bobek, Olivia; Chan, Irenaeus C. C.; Miller, Brian C.; Hillman, David W.; Heller, Glenn; Druley, Todd; Armstrong, Andrew J.; Morris, Michael J.; Milowsky, Matthew I.; Beltran, Himisha; Bolton, Kelly L.; Coombs, Catherine C.
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
NATURE IMMUNOLOGY
IF27.6
2024-09-170
PRE
Weiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.
Deciphering the effects of age on T cell immunity and immunotherapy
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Han, SeongJun; Georgiev, Peter; Schneider, Jaime; Huang, Amy; Nugmanova, Zhanel; Nguyen, Thao H.; Yao, Conghui; Johnson, Sheila; Joshi, Shakchhi; Dhiman, Ishita; Drijvers, Jefte M.; Fung, Megan; Rowe, Jared H.; Miller, Brian C.; Freeman, Gordon J.; Ringel, Alison E.; Haigis, Marcia C.; Sharpe, Arlene H.
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

神经母细胞瘤中的间充质和肾上腺素能细胞谱系状态具有不同的免疫原性表型

NATURE CANCER
IF28.5
2022-09-2233
OA
Sengupta, Satyaki; Das, Sanjukta; Crespo, Angela C.; Cornel, Annelisa M.; Patel, Anand G.; Mahadevan, Navin R.; Campisi, Marco; Ali, Alaa K.; Sharma, Bandana; Rowe, Jared H.; Huang, Hao; Debruyne, David N.; Cerda, Esther D.; Krajewska, Malgorzata; Dries, Ruben; Chen, Minyue; Zhang, Shupei; Soriano, Luigi; Cohen, Malkiel A.; Versteeg, Rogier; Jaenisch, Rudolf; Spranger, Stefani; Romee, Rizwan; Miller, Brian C.; Barbie, David A.; Nierkens, Stefan; Dyer, Michael A.; Lieberman, Judy; George, Rani E.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

SETDB1的表观遗传沉默抑制肿瘤内在免疫原性

Nature
IF48.5
2021-05-050
PREAI
Gabriel K. Griffin; Jingyi Wu; Arvin Iracheta-Vellve; James C. Patti; Jeffrey Hsu; Thomas Davis; Deborah Dele-Oni; Peter P. Du; Aya G. Halawi; Jeffrey J. Ishizuka; Sarah Y. Kim; Susan Klaeger; Nelson H. Knudsen; Brian C. Miller; Tung H. Nguyen; Kira E. Olander; Malvina Papanastasiou; Suzanna Rachimi; Emily J. Robitschek; Emily M. Schneider; Mitchell D. Yeary; Margaret D. Zimmer; Jacob D. Jaffe; Steven A. Carr; John G. Doench; W. Nicholas Haining; Kathleen B. Yates; Robert T. Manguso; Bradley E. Bernstein
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade (vol 20, pg 326, 2019)
NATURE IMMUNOLOGY
IF27.6
2019-10-0313
OAAI
Miller, Brian C.; Sen, Debattama R.; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V.; LaFleur, Martin W.; Yates, Kathleen B.; Lako, Ana; Felt, Kristen; Naik, Girish S.; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R.; Ishizuka, Jeffrey J.; Collier, Jenna L.; Griffin, Gabriel K.; Maleri, Seth; Comstock, Dawn E.; Weiss, Sarah A.; Brown, Flavian D.; Panda, Arpit; Zimmer, Margaret D.; Manguso, Robert T.; Hodi, F. Stephen; Rodig, Scott J.; Sharpe, Arlene H.; Haining, W. Nicholas
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

耗竭的CD8 T细胞亚群差异介导肿瘤控制并响应检查点阻断

NATURE IMMUNOLOGY
IF27.6
2019-02-181.3K
OAAI
Miller, Brian C.; Sen, Debattama R.; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V.; LaFleur, Martin W.; Yates, Kathleen B.; Lako, Ana; Felt, Kristen; Naik, Girish S.; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R.; Ishizuka, Jeffrey J.; Collier, Jenna L.; Griffin, Gabriel K.; Maleri, Seth; Comstock, Dawn E.; Weiss, Sarah A.; Brown, Flavian D.; Panda, Arpit; Zimmer, Margaret D.; Manguso, Robert T.; Hodi, F. Stephen; Rodig, Scott J.; Sharpe, Arlene H.; Haining, W. Nicholas

研究方向

暂未获取到该数据
A
Arlene H. Sharpe
H 指数:154论文数:744被引数:11.0万
K
Kevin Bi
H 指数:20论文数:78被引数:7,391
W
W. Nicholas Haining
H 指数:54论文数:193被引数:2.6万
K
Kathleen B. Yates
H 指数:26论文数:81被引数:8,122
D
Debattama R. Sen
H 指数:21论文数:56被引数:7,181
R
Rose Al Abosy
H 指数:6论文数:16被引数:2,708
R
Robert T. Manguso
H 指数:23论文数:105被引数:6,899
M
Martin W. LaFleur
H 指数:22论文数:104被引数:8,555
J
John G. Doench
H 指数:80论文数:737被引数:4.4万
H
Herbert W. Virgin
H 指数:132论文数:398被引数:7.8万