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D

Davide Trotti

Thomas Jefferson University

H指数:46

被引数:8,058

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Increased neuronal activity restores circadian function in Drosophila models of C9orf72-ALS/FTD

增加神经元活动可恢复C9orf72-ALS/FTD果蝇模型中的昼夜节律功能

IF4.1

2026-01-240

OAAI

NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats

COMMUNICATIONS BIOLOGY

IF5.1

2025-01-020

OAAI

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2024-10-012

OAAI

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes

葡萄糖代谢减退提示RAN翻译并加剧C9orf72-related ALS/FTD表型

IF6.2

2024-04-292

OA

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD

COMMUNICATIONS BIOLOGY

IF5.1

2024-03-280

OAAI

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

IF0

2024-01-153

OAAI

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2023-12-045

OAAI

Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia

家族性肌萎缩性侧索硬化症-额颞痴呆的PML核体丢失

CELL DEATH DISCOVERY

IF7

2023-07-154

OAAI

Breakdown of the central synapses in C9orf72-linked ALS/FTD

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2022-09-167

OAAI

Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis

NEUROTHERAPEUTICS

IF6.9

2022-07-0114

OA

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility

NATURE COMMUNICATIONS

IF15.7

2022-06-1327

OAAI

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice

IF5.1

2022-04-267

OA

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes

SCIENTIFIC REPORTS

IF3.9

2022-04-0416

OAAI

Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis

IF8.3

2021-03-3137

OA

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment

EMBO MOLECULAR MEDICINE

IF8.3

2020-04-2939

OAAI

Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress

C9orf72-ALS/FTD中与重复相关的非AUG翻译是由神经元兴奋和压力驱动的

EMBO MOLECULAR MEDICINE

IF8.3

2019-01-07100

OAAI

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

NATURE MEDICINE

IF50

2018-02-05445

OAAI

Shi, Yingxiao; Lin, Shaoyu; Staats, Kim A.; Li, Yichen; Chang, Wen-Hsuan; Hung, Shu-Ting; Hendricks, Eric; Linares, Gabriel R.; Wang, Yaoming; Son, Esther Y.; Wen, Xinmei; Kisler, Kassandra; Wilkinson, Brent; Menendez, Louise; Sugawara, Tohru; Woolwine, Phillip; Huang, Mickey; Cowan, Michael J.; Ge, Brandon; Koutsodendris, Nicole; Sandor, Kaitlin P.; Komberg, Jacob; Vangoor, Vamshidhar R.; Senthilkumar, Ketharini; Hennes, Valerie; Seah, Carina; Nelson, Amy R.; Cheng, Tze-Yuan; Lee, Shih-Jong J.; August, Paul R.; Chen, Jason A.; Wisniewski, Nicholas; Hanson-Smith, Victor; Belgard, T. Grant; Zhang, Alice; Coba, Marcelo; Grunseich, Chris; Ward, Michael E.; van den Berg, Leonard H.; Pasterkamp, R. Jeroen; Trotti, Davide; Zlokovic, Berislav V.; Ichida, Justin K.

Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha

IF5.1

2018-01-3083

OAAI

Muscles secretion of toxic factors regulated by miR126-5P facilitate motor neuron degeneration in ALS

JOURNAL OF THE NEUROLOGICAL SCIENCES

IF3.2

2017-10-010

PREAI

Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies

IF3.7

2017-08-0429

OAAI