未登录 A ROLE FOR BRAF FUSION PARTNERS IN ONCOGENIC SIGNALING Misek, Sean; Borgenvik, Anna; Fekade, Ruth; Zhang, Alexander; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung Hyun; Goodale, Amy; Condurat, Alexandra-Larisa; Cordero, Carolina; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadhayay, Pratiti 分享 收藏
BEYOND MAPK SIGNALING - GENOME-SCALE CRISPR/CAS9 SCREENS REVEAL NEW TARGETS FOR TREATMENT OF KIAA1549::BRAF-DRIVEN PEDIATRIC LOW-GRADE GLIOMA Borgenvik, Anna; Misek, Sean; Zhang, Alexander; Fekade, Ruth; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung (Riley) H.; Goodale, Amy; Condurat, Alexandra L.; Cordero, Carolina Ortiz; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadahayay, Pratiti (Mimi) 分享 收藏
NQO1 AS A RESISTANCE DRIVER AND THERAPEUTIC TARGET IN DMG Lupien, Leslie E.; Morin, Eric; Zhang, Daren F.; Novikov, Dana R.; Chacon, Madison S.; Khuu, Nicholas; Keshishian, Hasmik; Seidel, Olivia; Carr, Steven A.; Goodale, Amy; Persky, Nicole S.; Root, David E.; Cusick, Margaret; Ligon, Keith L.; Beroukhim, Rameen; Phoenix, Timothy M.; Rendo, Veronica; Bandopadhayay, Pratiti 分享 收藏
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants (Vol 15, 2742, 2024) EGFR的综合突变扫描揭示了细胞外结构域突变体的TKI敏感性 (第15卷，2742，2024) Hayes, Tikvah K.; Aquilanti, Elisa; Persky, Nicole S.; Yang, Xiaoping; Kim, Erica E.; Brenan, Lisa; Goodale, Amy B.; Alan, Douglas; Sharpe, Ted; Shue, Robert E.; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R.; Morris, Myshal D.; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y.; Cherniack, Andrew D.; Piccioni, Federica; Hicks, J. Kevin; Chi, Andrew S.; Cahill, Daniel P.; Dietrich, Jorg; Batchelor, Tracy T.; Root, David E.; Johannessen, Cory M.; Meyerson, Matthew 分享 收藏
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations 用匹配的化学和遗传扰动处理的细胞的300万张图像和形态特征 Chandrasekaran, Srinivas Niranj; Cimini, Beth A.; Goodale, Amy; Miller, Lisa; Kost-Alimova, Maria; Jamali, Nasim; Doench, John G.; Fritchman, Briana; Skepner, Adam; Melanson, Michelle; Kalinin, Alexandr A.; Arevalo, John; Haghighi, Marzieh; Caicedo, Juan C.; Kuhn, Daniel; Hernandez, Desiree; Berstler, James; Shafqat-Abbasi, Hamdah; Root, David E.; Swalley, Susanne E.; Garg, Sakshi; Singh, Shantanu; Carpenter, Anne E. 分享 收藏
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants EGFR的综合突变扫描揭示了细胞外结构域突变体的TKI敏感性 Hayes, Tikvah K.; Aquilanti, Elisa; Persky, Nicole S.; Yang, Xiaoping; Kim, Erica E.; Brenan, Lisa; Goodale, Amy B.; Alan, Douglas; Sharpe, Ted; Shue, Robert E.; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R.; Morris, Myshal D.; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y.; Cherniack, Andrew D.; Piccioni, Federica; Hicks, J. Kevin; Chi, Andrew S.; Cahill, Daniel P.; Dietrich, Jorg; Batchelor, Tracy T.; Root, David E.; Johannessen, Cory M.; Meyerson, Matthew 分享 收藏
Deep mutational scanning of EGFR reveals potential domain-specific TKI sensitivities in lung cancer and glioblastoma Hayes, Tikvah; Aquilanti, Elisa; Kim, Erica; Persky, Nicole; Brenan, Lisa; Goodale, Amy; Sharpe, Ted; Alan, Doug; Shue, Robert; Golomb, Lior; Silverman, Brianna; Li, Yvonne; Westlake, Lindsay; Piccioni, Federica; Cherniack, Andrew; Yang, Xiaoping Yang; Root, David; Hicks, J. Kevin; Chi, Andrew; Dietrich, Jorg; Cahill, Daniel; Johannessen, Cory; Batchelor, Tracy; Meyerson, Matthew 分享 收藏
Modular vector assembly enables rapid assessment of emerging CRISPR technologies McGee, Abby, V; Liu, Yanjing, V; Griffith, Audrey L.; Szegletes, Zsofia M.; Wen, Bronte; Kraus, Carolyn; Miller, Nathan W.; Steger, Ryan J.; Velasco, Berta Escude; Bosch, Justin A.; Zirin, Jonathan D.; Viswanatha, Raghuvir; Sontheimer, Erik J.; Goodale, Amy; Greene, Matthew A.; Green, Thomas M.; Doench, John G. 分享 收藏
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma Hofman, Damon A.; Ruiz-Orera, Jorge; Yannuzzi, Ian; Murugesan, Rakesh; Brown, Adam; Clauser, Karl R.; Condurat, Alexandra L.; van Dinter, Jip T.; Engels, Sem A. G.; Goodale, Amy; van der Lugt, Jasper; Abid, Tanaz; Wang, Li; Zhou, Kevin N.; Vogelzang, Jayne; Ligon, Keith L.; Phoenix, Timothy N.; Roth, Jennifer A.; Root, David E.; Hubner, Norbert; Golub, Todd R.; Bandopadhayay, Pratiti; van Heesch, Sebastiaan; Prensner, John R. 分享 收藏
Optimization of Cas12a for multiplexed genome-scale transcriptional activation Griffith, Audrey L.; Zheng, Fengyi; Mcgee, Abby V.; Miller, Nathan W.; Szegletes, Zsofia M.; Reint, Ganna; Gademann, Fabian; Nwolah, Ifunanya; Hegde, Mudra; Liu, Yanjing V.; Goodale, Amy; Doench, John G. 分享 收藏
Optimizing the Cell Painting assay for image-based profiling 优化基于图像的分析的细胞绘画分析 Cimini, Beth A.; Chandrasekaran, Srinivas Niranj; Kost-Alimova, Maria; Miller, Lisa; Goodale, Amy; Fritchman, Briana; Byrne, Patrick; Garg, Sakshi; Jamali, Nasim; Logan, David J.; Concannon, John B.; Lardeau, Charles-Hugues; Mouchet, Elizabeth; Singh, Shantanu; Abbasi, Hamdah Shafqat; Aspesi, Jr Peter; Boyd, Justin D.; Gilbert, Tamara; Gnutt, David; Hariharan, Santosh; Hernandez, Desiree; Hormel, Gisela; Juhani, Karolina; Melanson, Michelle; Mervin, Lewis H.; Monteverde, Tiziana; Pilling, James E.; Skepner, Adam; Swalley, Susanne E.; Vrcic, Anita; Weisbart, Erin; Williams, Guy; Yu, Shan; Zapiec, Bolek; Carpenter, Anne E. 分享 收藏
BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA BAF复杂扰动作为H3K27M小儿神经胶质瘤的新治疗机会 Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh; Hoffman, Samantha; Kugener, Guillaume; Shaw, McKenzie; Hack, Olivia; Dempster, Joshua; Lareau, Caleb; Quezada, Michael; Stanton, Ann-Catherine; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John; Root, David; Anastas, Jamie; Jones, Kristen; Conway, Amy; Stopka, Sylwia; Regan, Michael; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Mathewson, Nathan; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Nguyen, Quang-De; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
Genome-wide pooled CRISPR screening in neurospheres Abid, Tanaz; Goodale, Amy B.; Kalani, Zohra; Wyatt, Meghan; Gonzalez, Elizabeth M.; Zhou, Kevin Ning; Qian, Kenin; Novikov, Dana; Condurat, Alexandra-Larisa; Bandopadhayay, Pratiti; Piccioni, Federica; Persky, Nicole S.; Root, David E. 分享 收藏
Mapping the landscape of genetic dependencies in chordoma Sharifnia, Tanaz; Wawer, Mathias J.; Goodale, Amy; Lee, Yenarae; Kazachkova, Mariya; Dempster, Joshua M.; Muller, Sandrine; Levy, Joan; Freed, Daniel M.; Sommer, Josh; Kalfon, Jeremie; Vazquez, Francisca; Hahn, William C.; Root, David E.; Clemons, Paul A.; Schreiber, Stuart L. 分享 收藏
Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors Malone, Clare F.; Kim, Minjee; Alexe, Gabriela; Engel, Kathleen; Forman, Alexandra B.; Robichaud, Amanda; Conway, Amy Saur; Goodale, Amy; Meyer, Ashleigh; Khalid, Delan; Thayakumar, Allen; Hatcher, John M.; Gray, Nathanael S.; Piccioni, Federica; Stegmaier, Kimberly 分享 收藏
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria C.; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh, V; Li, Deyao; Hoffman, Samantha E.; Kugener, Guillaume; Shaw, McKenzie L.; Mire, Hafsa M.; Hack, Olivia A.; Dempster, Joshua M.; Lareau, Caleb; Dai, Lingling; Sigua, Logan H.; Quezada, Michael A.; Stanton, Ann-Catherine J.; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John G.; Root, David E.; Anastas, Jamie N.; Jones, Kristen L.; Conway, Amy Saur; Stopka, Sylwia; Regan, Michael S.; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Jerome, William P.; Mathewson, Nathan D.; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Quang-De Nguyen; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation PPM1D突变是从头弥漫性中线胶质瘤形成的致癌驱动因素 Khadka, Prasidda; Reitman, Zachary J.; Lu, Sophie; Buchan, Graham; Gionet, Gabrielle; Dubois, Frank; Carvalho, Diana M.; Shih, Juliann; Zhang, Shu; Greenwald, Noah F.; Zack, Travis; Shapira, Ofer; Pelton, Kristine; Hartley, Rachel; Bear, Heather; Georgis, Yohanna; Jarmale, Spandana; Melanson, Randy; Bonanno, Kevin; Schoolcraft, Kathleen; Miller, Peter G.; Condurat, Alexandra L.; Gonzalez, Elizabeth M.; Qian, Kenin; Morin, Eric; Langhnoja, Jaldeep; Lupien, Leslie E.; Rendo, Veronica; Digiacomo, Jeromy; Wang, Dayle; Zhou, Kevin; Kumbhani, Rushil; Garcia, Maria E. Guerra; Sinai, Claire E.; Becker, Sarah; Schneider, Rachel; Vogelzang, Jayne; Krug, Karsten; Goodale, Amy; Abid, Tanaz; Kalani, Zohra; Piccioni, Federica; Beroukhim, Rameen; Persky, Nicole S.; Root, David E.; Carcaboso, Angel M.; Ebert, Benjamin L.; Fuller, Christine; Babur, Ozgun; Kieran, Mark W.; Jones, Chris; Keshishian, Hasmik; Ligon, Keith L.; Carr, Steven A.; Phoenix, Timothy N.; Bandopadhayay, Pratiti 分享 收藏
Noncanonical open reading frames encode functional proteins essential for cancer cell survival Prensner, John R.; Enache, Oana M.; Luria, Victor; Krug, Karsten; Clauser, Karl R.; Dempster, Joshua M.; Karger, Amir; Wang, Li; Stumbraite, Karolina; Wang, Vickie M.; Botta, Ginevra; Lyons, Nicholas J.; Goodale, Amy; Kalani, Zohra; Fritchman, Briana; Brown, Adam; Alan, Douglas; Green, Thomas; Yang, Xiaoping; Jaffe, Jacob D.; Roth, Jennifer A.; Piccioni, Federica; Kirschner, Marc W.; Ji, Zhe; Root, David E.; Golub, Todd R. 分享 收藏
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia Cremer, Anjali; Ellegast, Jana M.; Alexe, Gabriela; Frank, Elizabeth S.; Ross, Linda; Chu, Haihua; Pikman, Yana; Robichaud, Amanda; Goodale, Amy; Hauepl, Bjorn; Mohr, Sebastian; Rao, Arati V.; Walker, Alison R.; Blachly, James S.; Piccioni, Federica; Armstrong, Scott A.; Byrd, John C.; Oellerich, Thomas; Stegmaier, Kimberly 分享 收藏
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