未登录 ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML Palacino, James; Lee, Pedro; Jeong, Hangyeol; Kim, Yeonjoon; Song, Yoojin; Permpoon, Uttapol; Wong, Wesley; Bai, Chen; Fishkin, Nathan; Takouri, Khuloud; Yu, Eunjun; Yi, Yong; Skaletskaya, Anna; Kim, Min-Soo; Kim, Da-Yeong; Choi, Dong-Ki; Park, Peter U. 分享 收藏
Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029, a potent GSPT1 degrader Saini, Shikha; Kim, Yeonjoon; Wong, Wesley; Karunaratne, Tina; Christensen, Olaf; Dutta, Sujoy; Bhar, Palash; Takrouri, Khuloud; Fishkin, Nathan; Choi, Dong-Ki; Kim, Min-Soo; Lim, Joanne; Skaletskaya, Anna; Palacino, James; Park, Peter 分享 收藏
A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1 Lim, Joanne; Skaletskaya, Anna; Permpoon, Uttapol; Kim, Yeonjoon; Saini, Shikha; Takrouri, Khuloud; Ribkovskaia, Zinaida; Bhar, Palash; Fishkin, Nathan; Choi, Dong-Ki; Park, Ji Hyun; Palacino, James; Park, Peter U. 分享 收藏
Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators Aird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators Aird, Daniel; Teng, Teng; Huang, Chia-Ling; Pazolli, Ermira; Banka, Deepti; Cheung-Ong, Kahlin; Eifert, Cheryl; Furman, Craig; Wu, Zhenhua Jeremy; Seiler, Michael; Buonamici, Silvia; Fekkes, Peter; Karr, Craig; Palacino, James; Park, Eunice; Smith, Peter G.; Yu, Lihua; Mizui, Yoshiharu; Warmuth, Markus; Chicas, Agustin; Corson, Laura; Zhu, Ping 分享 收藏
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High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration Al-Ramahi, Ismael; Lu, Boxun; Di Paola, Simone; Pang, Kaifang; de Haro, Maria; Peluso, Ivana; Gallego-Flores, Tatiana; Malik, Nazish T.; Erikson, Kelly; Bleiberg, Benjamin A.; Avalos, Matthew; Fan, George; Rivers, Laura Elizabeth; Laitman, Andrew M.; Diaz-Garcia, Javier R.; Hild, Marc; Palacino, James; Liu, Zhandong; Medina, Diego L.; Botas, Juan 分享 收藏
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A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex Teng, Teng; Tsai, Jennifer; Puyang, Xiaoling; Seiler, Michael; Peng, Shouyong; Aird, Daniel; Buonamici, Silvia; Caleb, Benjamin; Chan, Betty; Corson, Laura; Feala, Jacob; Fekkes, Peter; Karr, Craig; Korpal, Manav; Mizui, Yoshiharu; Park, Eunice; Palacino, James; Smith, Peter; Subramanian, Vanitha; Wu, Jeremy; Yu, Lihua; Chicas, Agustin; Warmuth, Markus; Larsen, Nicholas; Zhu, Ping 分享 收藏
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex Teng, Teng; Tsai, Jennifer H. C.; Puyang, Xiaoling; Seiler, Michael; Peng, Shouyong; Prajapati, Sudeep; Aird, Daniel; Buonamici, Silvia; Caleb, Benjamin; Chan, Betty; Corson, Laura; Feala, Jacob; Fekkes, Peter; Gerard, Baudouin; Karr, Craig; Korpal, Manav; Liu, Xiang; Lowe, Jason T.; Mizui, Yoshiharu; Palacino, James; Park, Eunice; Smith, Peter G.; Subramanian, Vanitha; Wu, Zhenhua Jeremy; Zou, Jian; Yu, Lihua; Chicas, Agustin; Warmuth, Markus; Larsen, Nicholas; Zhu, Ping 分享 收藏
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins (vol 22, pg 672, 2016) Lee, Stanley Chun-Wei; Dvinge, Heidi; Kim, Eunhee; Cho, Hana; Micol, Jean-Baptiste; Chung, Young Rock; Durham, Benjamin H.; Yoshimi, Akihide; Kim, Young Joon; Thomas, Michael; Lobry, Camille; Chen, Chun-Wei; Pastore, Alessandro; Taylor, Justin; Wang, Xujun; Krivtsov, Andrei; Armstrong, Scott A.; Palacino, James; Buonamici, Silvia; Smith, Peter G.; Bradley, Robert K.; Abdel-Wahab, Omar 分享 收藏
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins Lee, Stanley Chun-Wei; Dvinge, Heidi; Kim, Eunhee; Cho, Hana; Micol, Jean-Baptiste; Chung, Young Rock; Durham, Benjamin H.; Yoshimi, Akihide; Kim, Young Joon; Thomas, Michael; Lobry, Camille; Chen, Chun-Wei; Pastore, Alessandro; Taylor, Justin; Wang, Xujun; Krivtsov, Andrei; Armstrong, Scott A.; Palacino, James; Buonamici, Silvia; Smith, Peter G.; Bradley, Robert K.; Abdel-Wahab, Omar 分享 收藏
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015) Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015) Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev 分享 收藏
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity Yao, Yuwei; Cui, Xiaotian; Al-Ramahi, Ismael; Sun, Xiaoli; Li, Bo; Hou, Jiapeng; Difiglia, Marian; Palacino, James; Wu, Zhi-Ying; Ma, Lixiang; Botas, Juan; Lu, Boxun 分享 收藏
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Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors Kegel, Kimberly B.; Sapp, Ellen; Alexander, Jonathan; Reeves, Patrick; Bleckmann, Dorothee; Sobin, Linsday; Masso, Nicholas; Valencia, Antonio; Jeong, Hyunkyung; Krainc, Dimitri; Palacino, James; Curtis, Daniel; Kuhn, Rainer; Betschart, Claudia; Sena-Esteves, Miguel; Aronin, Neil; Paganetti, Paolo; DiFiglia, Marian 分享 收藏
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